TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Bayreuth
Curated by ChEMBL
University Of Bayreuth
Curated by ChEMBL
Affinity DataKi: 2.18E+3nMAssay Description:Uncompetitive inhibition of human N-terminal His6-SUMO-tagged SIRT2 catalytic domain (43 to 356 residues) deacetylase activity expressed in Escherich...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Bayreuth
Curated by ChEMBL
University Of Bayreuth
Curated by ChEMBL
Affinity DataKi: 2.22E+3nMAssay Description:Uncompetitive inhibition of human N-terminal His6-SUMO-tagged SIRT2 catalytic domain (43 to 356 residues) deacetylase activity expressed in Escherich...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Naples
Curated by ChEMBL
University Of Naples
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS2 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Naples
Curated by ChEMBL
University Of Naples
Curated by ChEMBL
Affinity DataIC50: 6.10nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS1 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
Affinity DataIC50: 9.10nMAssay Description:Inhibition of full length human C-terminal His-tagged PARP1 expressed in baculovirus infected Sf9 cells using chicken core histone as substrate incub...More data for this Ligand-Target Pair
Affinity DataIC50: 9.30nMAssay Description:Inhibition of full length human C-terminal His-tagged PARP1 expressed in baculovirus infected Sf9 cells using chicken core histone as substrate incub...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Naples
Curated by ChEMBL
University Of Naples
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS2 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of full length human N-terminal His-tagged PARP2 expressed in baculovirus infected Sf9 cells using histone H3.3 as substrate incubated for...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Naples
Curated by ChEMBL
University Of Naples
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS2 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Naples
Curated by ChEMBL
University Of Naples
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS1 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of full length human N-terminal His-tagged PARP2 expressed in baculovirus infected Sf9 cells using histone H3.3 as substrate incubated for...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Naples
Curated by ChEMBL
University Of Naples
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS1 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Naples
Curated by ChEMBL
University Of Naples
Curated by ChEMBL
Affinity DataIC50: 53nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS2 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of full length human C-terminal His-tagged PARP1 expressed in baculovirus infected Sf9 cells using chicken core histone as substrate incub...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Naples
Curated by ChEMBL
University Of Naples
Curated by ChEMBL
Affinity DataIC50: 103nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS2 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Naples
Curated by ChEMBL
University Of Naples
Curated by ChEMBL
Affinity DataIC50: 193nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS2 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Naples
Curated by ChEMBL
University Of Naples
Curated by ChEMBL
Affinity DataIC50: 218nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS1 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Naples
Curated by ChEMBL
University Of Naples
Curated by ChEMBL
Affinity DataIC50: 303nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS1 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Naples
Curated by ChEMBL
University Of Naples
Curated by ChEMBL
Affinity DataIC50: 318nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS2 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
Affinity DataIC50: 340nMAssay Description:Inhibition of full length human N-terminal His-tagged PARP2 expressed in baculovirus infected Sf9 cells using histone H3.3 as substrate incubated for...More data for this Ligand-Target Pair
Affinity DataIC50: 347nMAssay Description:Inhibition of full length human N-terminal His-tagged PARP2 expressed in baculovirus infected Sf9 cells using histone H3.3 as substrate incubated for...More data for this Ligand-Target Pair
Affinity DataIC50: 356nMAssay Description:Inhibition of full length human C-terminal His-tagged PARP1 expressed in baculovirus infected Sf9 cells using chicken core histone as substrate incub...More data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Inhibition of full length human N-terminal His-tagged PARP2 expressed in baculovirus infected Sf9 cells using histone H3.3 as substrate incubated for...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Naples
Curated by ChEMBL
University Of Naples
Curated by ChEMBL
Affinity DataIC50: 398nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS1 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
Affinity DataIC50: 549nMAssay Description:Inhibition of full length human N-terminal His-tagged PARP2 expressed in baculovirus infected Sf9 cells using histone H3.3 as substrate incubated for...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Naples
Curated by ChEMBL
University Of Naples
Curated by ChEMBL
Affinity DataIC50: 552nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS1 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Naples
Curated by ChEMBL
University Of Naples
Curated by ChEMBL
Affinity DataIC50: 588nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS2 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Naples
Curated by ChEMBL
University Of Naples
Curated by ChEMBL
Affinity DataIC50: 673nMAssay Description:Inhibition of full length human N-terminal GST-tagged TNKS1 ADP-ART catalytic domain (1001 to 1327 residues) using histone H2A as substrate incubated...More data for this Ligand-Target Pair
Affinity DataIC50: 963nMAssay Description:Inhibition of full length human N-terminal His-tagged PARP2 expressed in baculovirus infected Sf9 cells using histone H3.3 as substrate incubated for...More data for this Ligand-Target Pair
Affinity DataIC50: 1.28E+3nMAssay Description:Inhibition of full length human C-terminal His-tagged PARP1 expressed in baculovirus infected Sf9 cells using chicken core histone as substrate incub...More data for this Ligand-Target Pair
Affinity DataIC50: 1.48E+3nMAssay Description:Inhibition of full length human C-terminal His-tagged PARP1 expressed in baculovirus infected Sf9 cells using chicken core histone as substrate incub...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Bayreuth
Curated by ChEMBL
University Of Bayreuth
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human N-terminal His6-SUMO-tagged SIRT2 catalytic domain (43 to 356 residues) deacetylase activity expressed in Escherichia coli using ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.04E+3nMAssay Description:Inhibition of full length human C-terminal His-tagged PARP1 expressed in baculovirus infected Sf9 cells using chicken core histone as substrate incub...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Bayreuth
Curated by ChEMBL
University Of Bayreuth
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human N-terminal His6-SUMO-tagged SIRT2 catalytic domain (43 to 356 residues) deacetylase activity expressed in Escherichia coli using ...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Bayreuth
Curated by ChEMBL
University Of Bayreuth
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human N-terminal His6-SUMO-tagged SIRT2 catalytic domain (43 to 356 residues) deacetylase activity expressed in Escherichia coli using ...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Bayreuth
Curated by ChEMBL
University Of Bayreuth
Curated by ChEMBL
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of human N-terminal His6-SUMO-tagged SIRT2 catalytic domain (43 to 356 residues) deacetylase activity expressed in Escherichia coli using ...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Bayreuth
Curated by ChEMBL
University Of Bayreuth
Curated by ChEMBL
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of human N-terminal His6-SUMO-tagged SIRT2 catalytic domain (43 to 356 residues) deacetylase activity expressed in Escherichia coli using ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha inhibitor(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human FIH using HLEVVKLLLEAGADVNAQDK-CONH2 as substrate preincubated for 15 mins followed by substrate addition and measured after 15 m...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Bayreuth
Curated by ChEMBL
University Of Bayreuth
Curated by ChEMBL
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of human N-terminal His6-SUMO-tagged SIRT2 catalytic domain (43 to 356 residues) deacetylase activity expressed in Escherichia coli using ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha inhibitor(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of human FIH using HLEVVKLLLEAGADVNAQDK-CONH2 as substrate preincubated for 15 mins followed by substrate addition and measured after 15 m...More data for this Ligand-Target Pair
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of human N-terminal His6-tagged KDM4A (M1 to L359 residues) expressed in Escherichia coli using H3K9(Me3) as substrate preincubated for 15...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Bayreuth
Curated by ChEMBL
University Of Bayreuth
Curated by ChEMBL
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition of human N-terminal His6-SUMO-tagged SIRT2 catalytic domain (43 to 356 residues) deacetylase activity expressed in Escherichia coli using ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha inhibitor(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of human FIH using HLEVVKLLLEAGADVNAQDK-CONH2 as substrate preincubated for 15 mins followed by substrate addition and measured after 15 m...More data for this Ligand-Target Pair
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibition of human N-terminal His6-tagged KDM4A (M1 to L359 residues) expressed in Escherichia coli using H3K9(Me3) as substrate preincubated for 15...More data for this Ligand-Target Pair
Affinity DataIC50: 1.34E+4nMAssay Description:Inhibition of human N-terminal His6-tagged KDM4A (M1 to L359 residues) expressed in Escherichia coli using H3K9(Me3) as substrate preincubated for 15...More data for this Ligand-Target Pair
Affinity DataIC50: 1.43E+4nMAssay Description:Inhibition of human N-terminal His6-tagged KDM4A (M1 to L359 residues) expressed in Escherichia coli using H3K9(Me3) as substrate preincubated for 15...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha inhibitor(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 1.53E+4nMAssay Description:Inhibition of human FIH using HLEVVKLLLEAGADVNAQDK-CONH2 as substrate preincubated for 15 mins followed by substrate addition and measured after 15 m...More data for this Ligand-Target Pair
Affinity DataIC50: 1.55E+4nMAssay Description:Inhibition of human N-terminal His6-tagged KDM4D (M1 to G373 residues) expressed in Escherichia coli using H3K9(Me3) as substrate preincubated for 15...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha inhibitor(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 1.59E+4nMAssay Description:Inhibition of human FIH using HLEVVKLLLEAGADVNAQDK-CONH2 as substrate preincubated for 15 mins followed by substrate addition and measured after 15 m...More data for this Ligand-Target Pair
Affinity DataIC50: 1.65E+4nMAssay Description:Inhibition of human N-terminal His6-tagged KDM4A (M1 to L359 residues) expressed in Escherichia coli using H3K9(Me3) as substrate preincubated for 15...More data for this Ligand-Target Pair