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Found 113 with Last Name = 'pathak' and Initial = 'vk'
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Nih

Curated by ChEMBL
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of wild type HIV1 reverse transcriptase in 293T cellsMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Nih

Curated by ChEMBL
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataIC50:  6nMAssay Description:Inhibition of HIV1 reverse transcriptase Y181C mutant in 293T cellsMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Nih

Curated by ChEMBL
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of HIV1 reverse transcriptase Y188C mutant in 293T cellsMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Nih

Curated by ChEMBL
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataIC50:  54nMAssay Description:Inhibition of HIV1 reverse transcriptase K103N mutant in 293T cellsMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Nih

Curated by ChEMBL
LigandPNGBDBM1434(11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3...)
Affinity DataIC50:  60nMAssay Description:Inhibition of wild type HIV1 reverse transcriptase in 293T cellsMore data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50125697(4-(3,4-Bis-azidomethyl-phenyl)-2,4-dioxo-butyric a...)
Affinity DataIC50:  150nMAssay Description:Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50125697(4-(3,4-Bis-azidomethyl-phenyl)-2,4-dioxo-butyric a...)
Affinity DataIC50:  260nMAssay Description:Inhibitory concentration against Recombinant HIV-1 integrase (3'processing)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50125701(4-(5,8-Diazido-5,6,7,8-tetrahydro-naphthalen-2-yl)...)
Affinity DataIC50:  320nMAssay Description:Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115572((Z)-4-(3-Benzyloxy-phenyl)-2-hydroxy-4-oxo-but-2-e...)
Affinity DataIC50:  350nMAssay Description:Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115572((Z)-4-(3-Benzyloxy-phenyl)-2-hydroxy-4-oxo-but-2-e...)
Affinity DataIC50:  350nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50125699(4-(1,3-Diazido-indan-5-yl)-2,4-dioxo-butyric acid ...)
Affinity DataIC50:  360nMAssay Description:Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM107681((2Z)-4-[3,5-bis(benzyloxy)phenyl]-2-hydroxy-4- oxo...)
Affinity DataIC50:  480nMAssay Description:Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM107681((2Z)-4-[3,5-bis(benzyloxy)phenyl]-2-hydroxy-4- oxo...)
Affinity DataIC50:  480nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Nih

Curated by ChEMBL
LigandPNGBDBM50184085((2aR,7aR)-2-((R)-2-methyl-pyrrolidin-1-yl)-2aH-7-t...)
Affinity DataIC50:  500nMAssay Description:Inhibition of wild type HIV1 reverse transcriptase in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM107693((2Z)-4-(5-chloro-1H-indol-3-yl)-2-hydroxy-4-oxobut...)
Affinity DataIC50:  520nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50093435((Z)-1-(5-Chloro-1H-indol-3-yl)-3-hydroxy-3-(1H-tet...)
Affinity DataIC50:  650nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Nih

Curated by ChEMBL
LigandPNGBDBM50184082((R,R)-dimethyl-1-(1-piperidynyl)cyclobuta[b][1]ben...)
Affinity DataIC50:  800nMAssay Description:Inhibition of wild type HIV1 reverse transcriptase in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50370120(CHEMBL611459)
Affinity DataIC50:  810nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Nih

Curated by ChEMBL
LigandPNGBDBM1434(11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3...)
Affinity DataIC50:  860nMAssay Description:Inhibition of HIV1 reverse transcriptase Y188C mutant in 293T cellsMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Nih

Curated by ChEMBL
LigandPNGBDBM50184086((R,R/S,S)-dimethyl-1-(1-piperidynyl)cyclobuta[b][1...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of wild type HIV1 reverse transcriptase in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115582((Z)-4-[4-(3-Carboxy-3-hydroxy-acryloyl)-phenyl]-2-...)
Affinity DataIC50:  1.28E+3nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115570((Z)-2-Hydroxy-4-(1H-indol-3-yl)-4-oxo-but-2-enoic ...)
Affinity DataIC50:  1.43E+3nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50125705(4-[3-(2-Cyano-ethyl)-phenyl]-2,4-dioxo-butyric aci...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibitory concentration of the compound was determined against Recombinant HIV-1 integrase (Standard transfer reaction)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50125704(4-(3-Azidomethyl-phenyl)-2,4-dioxo-butyric acid | ...)
Affinity DataIC50:  1.53E+3nMAssay Description:Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115575(1-(5-Fluoro-1H-indol-3-yl)-3-hydroxy-3-(1H-tetrazo...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50125705(4-[3-(2-Cyano-ethyl)-phenyl]-2,4-dioxo-butyric aci...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115580((Z)-4-[3-(3-Carboxy-3-hydroxy-acryloyl)-phenyl]-2-...)
Affinity DataIC50:  1.83E+3nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115573(3-Hydroxy-1-(1H-indol-3-yl)-3-(1H-tetrazol-5-yl)-p...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay in experiment 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50125702(4-(3,5-Bis-azidomethyl-phenyl)-2,4-dioxo-butyric a...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115573(3-Hydroxy-1-(1H-indol-3-yl)-3-(1H-tetrazol-5-yl)-p...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay in experiment 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50083953((Z)-4-(3-Bromo-phenyl)-2-hydroxy-4-oxo-but-2-enoic...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay in experiment 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Nih

Curated by ChEMBL
LigandPNGBDBM50184096((2aR,7aR)-2-((S)-2-Methyl-pyrrolidin-1-yl)-2aH-7-t...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of wild type HIV1 reverse transcriptase in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50125702(4-(3,5-Bis-azidomethyl-phenyl)-2,4-dioxo-butyric a...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50083953((Z)-4-(3-Bromo-phenyl)-2-hydroxy-4-oxo-but-2-enoic...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay in experiment 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Nih

Curated by ChEMBL
LigandPNGBDBM50184089((R,R/S,S)-2-(2,5-dihydro-pyrrol-1-yl)-2aH-7-thia-c...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of wild type HIV1 reverse transcriptase in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Nih

Curated by ChEMBL
LigandPNGBDBM1434(11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3...)
Affinity DataIC50:  5.75E+3nMAssay Description:Inhibition of HIV1 reverse transcriptase K103N mutant in 293T cellsMore data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50125703(4-(4-Azidomethyl-phenyl)-2,4-dioxo-butyric acid | ...)
Affinity DataIC50:  6.10E+3nMAssay Description:Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115588(4-[2-(3-Carboxy-3-hydroxy-acryloyl)-quinolin-4-yl]...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Nih

Curated by ChEMBL
LigandPNGBDBM1434(11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3...)
Affinity DataIC50:  6.65E+3nMAssay Description:Inhibition of HIV1 reverse transcriptase Y181C mutant in 293T cellsMore data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115587(4-(5-Chloro-1H-indol-3-yl)-2-hydroxy-4-oxo-but-2-e...)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50125703(4-(4-Azidomethyl-phenyl)-2,4-dioxo-butyric acid | ...)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibitory concentration of the compound was determined against Recombinant HIV-1 integrase (Standard transfer reaction)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115582((Z)-4-[4-(3-Carboxy-3-hydroxy-acryloyl)-phenyl]-2-...)
Affinity DataIC50:  7.20E+3nMAssay Description:Inhibitory effect on 3'-processing(3'-P) of proviral DNA in an extracellular HIV-1 integrase assay in experiment 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115582((Z)-4-[4-(3-Carboxy-3-hydroxy-acryloyl)-phenyl]-2-...)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibitory effect on 3'-processing(3'-P) of proviral DNA in an extracellular HIV-1 integrase assay in experiment 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Nih

Curated by ChEMBL
LigandPNGBDBM50184091((2aR,7aR)-2-piperidin-1-yl-2aH-7-thia-cyclobuta[a]...)
Affinity DataIC50:  7.70E+3nMAssay Description:Inhibition of wild type HIV1 reverse transcriptase in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115581((Z)-2-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-but-2-eno...)
Affinity DataIC50:  7.80E+3nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assay in experiment 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115580((Z)-4-[3-(3-Carboxy-3-hydroxy-acryloyl)-phenyl]-2-...)
Affinity DataIC50:  7.80E+3nMAssay Description:Inhibitory effect on 3'-processing(3'-P) of proviral DNA in an extracellular HIV-1 integrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50125700(4-(3-Azidomethyl-4-methoxy-phenyl)-2,4-dioxo-butyr...)
Affinity DataIC50:  8.50E+3nMAssay Description:Inhibitory concentration of the compound was determined against Recombinant HIV-1 integrase (Standard transfer reaction)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Nih

Curated by ChEMBL
LigandPNGBDBM50184081((R,R/S,S)-2-piperidin-1-yl-2aH-7-thia-cyclobuta[a]...)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of wild type HIV1 reverse transcriptase in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50125700(4-(3-Azidomethyl-4-methoxy-phenyl)-2,4-dioxo-butyr...)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibitory concentration against Recombinant HIV-1 integrase (3'processing)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Nih

Curated by ChEMBL
LigandPNGBDBM50184095((R,R/S,S)-2-azetidin-1-yl-2aH-7-thia-cyclobuta[a]i...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of wild type HIV1 reverse transcriptase in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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