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Found 285 with Last Name = 'payne' and Initial = 'ls'
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50405190(CHEMBL2028991)
Affinity DataKi:  0.160nMAssay Description:Inhibition of ReninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50405190(CHEMBL2028991)
Affinity DataKi:  0.190nMAssay Description:The compound was tested for inhibition of rhesus monkey plasma renin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50006828(2-(2-{[1-(3-{2-[2-(2-Amino-3-hydroxy-propionylamin...)
Affinity DataKi:  0.240nMAssay Description:Compound was evaluated in vitro for the inhibition of HIV-Protease, using a peptide hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337483(CHEMBL1682777 | N1-(5-chloro-2-(1H-tetrazol-1-yl)b...)
Affinity DataKi:  0.270nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337479(CHEMBL1682781 | N-(5-chloro-2-(1H-tetrazol-1-yl)be...)
Affinity DataKi:  0.270nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025937(CHEMBL3144417 | {1-[1-{3-[1-(1-Carbamoyl-2-phenyl-...)
Affinity DataKi:  0.520nMAssay Description:Inhibition of ReninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50405190(CHEMBL2028991)
Affinity DataKi:  0.540nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337485(CHEMBL1682775 | N1-(2-(aminomethyl)-5-chlorobenzyl...)
Affinity DataKi:  0.680nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337487(CHEMBL1682773 | methyl 2-(4-chloro-2-(2-(3-(diisob...)
Affinity DataKi:  0.730nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337478(3-(3-(5-chloro-2-(1H-tetrazol-1-yl)benzylcarbamoyl...)
Affinity DataKi:  0.770nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025945(CHEMBL3144416 | {1-[1-{3-[1-(1-Carbamoyl-2-phenyl-...)
Affinity DataKi:  0.880nMAssay Description:Inhibition of human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337474(CHEMBL1682786 | N-(5-chloro-2-(1H-tetrazol-1-yl)be...)
Affinity DataKi:  0.930nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337488(3-(5-chloro-2-(1H-1,2,4-triazol-1-yl)phenethoxy)-N...)
Affinity DataKi:  0.930nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025941(CHEMBL3144415 | {1-[1-{3-[1-(1-Carbamoyl-2-phenyl-...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337472(CHEMBL1682788 | N-(5-chloro-2-(1H-tetrazol-1-yl)be...)
Affinity DataKi:  1.25nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337473(3-((2-aminoethyl)(cyclohexyl)amino)-N-(5-chloro-2-...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337486(3-(5-chloro-2-(2-oxo-2-(piperidin-3-ylamino)ethoxy...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337489(3-(2-(1H-tetrazol-1-yl)phenethoxy)-N,N-diisobutyl-...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337477(CHEMBL1682783 | N-(5-chloro-2-(1H-tetrazol-1-yl)be...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337491(3-(2-(aminomethyl)phenethoxy)-N,N-diisobutyl-5-met...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337493(CHEMBL1682767 | N,N-diisobutyl-3-methyl-5-(2-(5-me...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50405190(CHEMBL2028991)
Affinity DataKi:  3.70nMAssay Description:Binding affinity of the compound was determined against Nicotinic acetylcholine receptor using [3H]-(-)-nicotine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337475(CHEMBL1682785 | N-(5-chloro-2-(1H-tetrazol-1-yl)be...)
Affinity DataKi:  4.10nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50405191(CHEMBL269752)
Affinity DataKi:  6.20nMAssay Description:The compound was tested for inhibition of rabbit plasma renin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337484(CHEMBL1682776 | N1-(5-chloro-2-(1H-1,2,4-triazol-1...)
Affinity DataKi:  7nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025946(4-[2-(2-Acetylamino-3-phenyl-propionylamino)-3-(1H...)
Affinity DataKi:  7.70nMAssay Description:Inhibition of human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50405191(CHEMBL269752)
Affinity DataKi:  8.80nMAssay Description:Inhibition of human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337476(CHEMBL1682784 | N-(5-chloro-2-(1H-tetrazol-1-yl)be...)
Affinity DataKi:  9.60nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50405191(CHEMBL269752)
Affinity DataKi:  10nMAssay Description:Inhibition of ReninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025948(5-Cyclohexyl-3-hydroxy-4-[3-(1H-imidazol-4-yl)-2-(...)
Affinity DataKi:  14nMAssay Description:Inhibition of ReninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50405191(CHEMBL269752)
Affinity DataKi:  18nMAssay Description:Inhibition of human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50405192(CHEMBL2028990)
Affinity DataKi:  18nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50405190(CHEMBL2028991)
Affinity DataKi:  21nMpH: 7.4Assay Description:The compound was tested for inhibition of rat plasma renin at pH of 7.4.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50405190(CHEMBL2028991)
Affinity DataKi:  27nMAssay Description:The compound was tested for inhibition of rabbit liver cathepsin D.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A(Porcine)
TBA

Curated by ChEMBL
LigandPNGBDBM50405190(CHEMBL2028991)
Affinity DataKi:  28nMAssay Description:The compound was tested for inhibition of porcine pepsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337490(3-(5-chloro-2-methoxyphenethoxy)-N,N-diisobutyl-5-...)
Affinity DataKi:  34nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337492(3-(2,2-difluoro-2-(4-methylpyridin-2-yl)ethoxy)-N,...)
Affinity DataKi:  37nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025939(CHEMBL3144412 | {1-[1-{1-Benzyl-3-[1-(1-carbamoyl-...)
Affinity DataKi:  49nMAssay Description:Inhibition of human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337482(CHEMBL1682778 | N1-(2-(1H-tetrazol-1-yl)benzyl)-N3...)
Affinity DataKi:  50nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337481(CHEMBL1682779 | N-(5-chloro-2-(1H-tetrazol-1-yl)be...)
Affinity DataKi:  67nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337480(3-(4-acetylpyridin-3-yl)-N-(5-chloro-2-(1H-tetrazo...)
Affinity DataKi:  85nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50405191(CHEMBL269752)
Affinity DataKi:  115nMpH: 6.0Assay Description:The compound was tested for inhibition of rat plasma renin at pH of 6.0.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50022040(CHEMBL3085571 | {1-[1-(1-{2-[1-(1-Carbamoyl-2-phen...)
Affinity DataKi:  190nMAssay Description:Inhibition of human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025940(4-[2-(2-Acetylamino-3-phenyl-propionylamino)-3-(1H...)
Affinity DataKi:  210nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Rhizopus chinensis)
TBA

Curated by ChEMBL
LigandPNGBDBM50405190(CHEMBL2028991)
Affinity DataKi:  230nMpH: 7.4Assay Description:Inhibition of rhizopuspepsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Rhizopus chinensis)
TBA

Curated by ChEMBL
LigandPNGBDBM50405190(CHEMBL2028991)
Affinity DataKi:  230nMAssay Description:Binding affinity against nicotinic acetylcholine receptor alpha4-beta4 using [3H]epibatidine as radioligand expressed in HEK293 cells or tsA cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025944(3-Hydroxy-4-[3-(1H-imidazol-4-yl)-2-(2-phenoxy-ace...)
Affinity DataKi:  580nMAssay Description:Inhibition of human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50405191(CHEMBL269752)
Affinity DataKi:  630nMAssay Description:The compound was tested for inhibition of Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Rhizopus chinensis)
TBA

Curated by ChEMBL
LigandPNGBDBM50405191(CHEMBL269752)
Affinity DataKi:  630nMpH: 7.4Assay Description:Binding affinity against nicotinic acetylcholine receptor using [3H]epibatidine as radioligand in rat brain tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50405191(CHEMBL269752)
Affinity DataKi:  630nMAssay Description:The compound was tested for inhibition of rabbit liver cathepsin D.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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