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Found 47 with Last Name = 'pemberton' and Initial = 'oa'
TargetOXA23 carbapenemase(Acinetobacter baumannii)
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50541448(CHEMBL4633785)
Affinity DataKi:  0.740nMAssay Description:Inhibition of Acinetobacter baumannii OXA-23 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition measured every 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbapenem-hydrolyzing beta-lactamase KPC()
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50541448(CHEMBL4633785)
Affinity DataKi:  1.90nMAssay Description:Inhibition of recombinant Escherichia coli KPC-2 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition and measured e...More data for this Ligand-Target Pair
TargetVIM-1 metallo-beta-lactamase(Klebsiella pneumoniae)
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50541448(CHEMBL4633785)
Affinity DataKi:  8nMAssay Description:Inhibition of recombinant Escherichia coli VIM-1 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition measured every...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbapenem-hydrolyzing beta-lactamase KPC()
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50339145(CHEMBL1689063 | trans-7-oxo-6-(sulfooxy)-1,6-diaza...)
Affinity DataKi:  11nMAssay Description:Inhibition of recombinant Escherichia coli KPC-2 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition and measured e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbapenem-hydrolyzing beta-lactamase KPC()
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50541449(CHEMBL4636953)
Affinity DataKi:  21nMAssay Description:Inhibition of recombinant Escherichia coli KPC-2 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition and measured e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbapenem-hydrolyzing beta-lactamase KPC()
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50089084(CHEMBL3317857 | Vaborbactam)
Affinity DataKi:  56nMAssay Description:Inhibition of recombinant Escherichia coli KPC-2 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition and measured e...More data for this Ligand-Target Pair
TargetCarbapenem-hydrolyzing beta-lactamase KPC()
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50541450(CHEMBL4640702)
Affinity DataKi:  150nMAssay Description:Inhibition of recombinant Escherichia coli KPC-2 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition and measured e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin-associated domain-containing protein 1(Human)
University of South Florida

US Patent
LigandPNGBDBM426626(US10543221, Compound 994942 | US10543221, Formula ...)
Affinity DataKi:  488nMAssay Description:Expression and Purification of Beta-Lactamases. For his tag KPC-2 beta-lactamase, bacteria were grown overnight at 30 C with shaking in 50 mL LB brot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetUbiquitin-associated domain-containing protein 1(Human)
University of South Florida

US Patent
LigandPNGBDBM426620(US10543221, Compound 72588 | US10543221, Formula )
Affinity DataKi:  1.50E+3nMAssay Description:Expression and Purification of Beta-Lactamases. For his tag KPC-2 beta-lactamase, bacteria were grown overnight at 30 C with shaking in 50 mL LB brot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOXA23 carbapenemase(Acinetobacter baumannii)
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50339145(CHEMBL1689063 | trans-7-oxo-6-(sulfooxy)-1,6-diaza...)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibition of Acinetobacter baumannii OXA-23 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition measured every 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase ORTHRUS 5(Mouse-ear cress)
University of South Florida

US Patent
LigandPNGBDBM426626(US10543221, Compound 994942 | US10543221, Formula ...)
Affinity DataKi:  1.80E+3nMAssay Description:Expression and Purification of Beta-Lactamases. For his tag KPC-2 beta-lactamase, bacteria were grown overnight at 30 C with shaking in 50 mL LB brot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetUbiquitin-associated domain-containing protein 1(Human)
University of South Florida

US Patent
LigandPNGBDBM426631(US10543221, Compound 1014507 | US10543221, Formula...)
Affinity DataKi:  4.22E+3nMAssay Description:Expression and Purification of Beta-Lactamases. For his tag KPC-2 beta-lactamase, bacteria were grown overnight at 30 C with shaking in 50 mL LB brot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase ORTHRUS 5(Mouse-ear cress)
University of South Florida

US Patent
LigandPNGBDBM426628(US10543221, Compound 995015 | US10543221, Formula ...)
Affinity DataKi:  4.70E+3nMAssay Description:Expression and Purification of Beta-Lactamases. For his tag KPC-2 beta-lactamase, bacteria were grown overnight at 30 C with shaking in 50 mL LB brot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetUbiquitin-associated domain-containing protein 1(Human)
University of South Florida

US Patent
LigandPNGBDBM426625(US10543221, Compound 994284 | US10543221, Formula ...)
Affinity DataKi:  5.70E+3nMAssay Description:Expression and Purification of Beta-Lactamases. For his tag KPC-2 beta-lactamase, bacteria were grown overnight at 30 C with shaking in 50 mL LB brot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin-associated domain-containing protein 1(Human)
University of South Florida

US Patent
LigandPNGBDBM426628(US10543221, Compound 995015 | US10543221, Formula ...)
Affinity DataKi:  8.90E+3nMAssay Description:Expression and Purification of Beta-Lactamases. For his tag KPC-2 beta-lactamase, bacteria were grown overnight at 30 C with shaking in 50 mL LB brot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase ORTHRUS 5(Mouse-ear cress)
University of South Florida

US Patent
LigandPNGBDBM426627(US10543221, Compound 994943 | US10543221, Formula ...)
Affinity DataKi:  9.12E+3nMAssay Description:Expression and Purification of Beta-Lactamases. For his tag KPC-2 beta-lactamase, bacteria were grown overnight at 30 C with shaking in 50 mL LB brot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetUbiquitin-associated domain-containing protein 1(Human)
University of South Florida

US Patent
LigandPNGBDBM426524(US10543221, Compound 72875 | US10543221, Formula 5)
Affinity DataKi:  1.34E+4nMAssay Description:Expression and Purification of Beta-Lactamases. For his tag KPC-2 beta-lactamase, bacteria were grown overnight at 30 C with shaking in 50 mL LB brot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetUbiquitin-associated domain-containing protein 1(Human)
University of South Florida

US Patent
LigandPNGBDBM426622(US10543221, Compound 73475 | US10543221, Formula 8)
Affinity DataKi:  1.35E+4nMAssay Description:Expression and Purification of Beta-Lactamases. For his tag KPC-2 beta-lactamase, bacteria were grown overnight at 30 C with shaking in 50 mL LB brot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase ORTHRUS 5(Mouse-ear cress)
University of South Florida

US Patent
LigandPNGBDBM426630(US10543221, Compound 995018 | US10543221, Formula ...)
Affinity DataKi:  1.56E+4nMAssay Description:Expression and Purification of Beta-Lactamases. For his tag KPC-2 beta-lactamase, bacteria were grown overnight at 30 C with shaking in 50 mL LB brot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase ORTHRUS 5(Mouse-ear cress)
University of South Florida

US Patent
LigandPNGBDBM426629(US10543221, Compound 995016 | US10543221, Formula ...)
Affinity DataKi:  2.43E+4nMAssay Description:Expression and Purification of Beta-Lactamases. For his tag KPC-2 beta-lactamase, bacteria were grown overnight at 30 C with shaking in 50 mL LB brot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetUbiquitin-associated domain-containing protein 1(Human)
University of South Florida

US Patent
LigandPNGBDBM426621(US10543221, Compound 73043 | US10543221, Formula 7)
Affinity DataKi:  2.66E+4nMAssay Description:Expression and Purification of Beta-Lactamases. For his tag KPC-2 beta-lactamase, bacteria were grown overnight at 30 C with shaking in 50 mL LB brot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetUbiquitin-associated domain-containing protein 1(Human)
University of South Florida

US Patent
LigandPNGBDBM426624(US10543221, Compound 73152 | US10543221, Formula 1...)
Affinity DataKi:  3.95E+4nMAssay Description:Expression and Purification of Beta-Lactamases. For his tag KPC-2 beta-lactamase, bacteria were grown overnight at 30 C with shaking in 50 mL LB brot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVIM-1 metallo-beta-lactamase(Klebsiella pneumoniae)
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50089084(CHEMBL3317857 | Vaborbactam)
Affinity DataKi: >4.00E+4nMAssay Description:Inhibition of recombinant Escherichia coli VIM-1 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition measured every...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOXA23 carbapenemase(Acinetobacter baumannii)
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50089084(CHEMBL3317857 | Vaborbactam)
Affinity DataKi: >4.00E+4nMAssay Description:Inhibition of Acinetobacter baumannii OXA-23 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition measured every 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVIM-1 metallo-beta-lactamase(Klebsiella pneumoniae)
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50339145(CHEMBL1689063 | trans-7-oxo-6-(sulfooxy)-1,6-diaza...)
Affinity DataKi: >4.00E+4nMAssay Description:Inhibition of recombinant Escherichia coli VIM-1 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition measured every...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
University of South Florida

US Patent
LigandPNGBDBM426626(US10543221, Compound 994942 | US10543221, Formula ...)
Affinity DataKi:  5.50E+4nMAssay Description:Expression and Purification of Beta-Lactamases. For his tag KPC-2 beta-lactamase, bacteria were grown overnight at 30 C with shaking in 50 mL LB brot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetUbiquitin-associated domain-containing protein 1(Human)
University of South Florida

US Patent
LigandPNGBDBM426630(US10543221, Compound 995018 | US10543221, Formula ...)
Affinity DataKi:  7.92E+4nMAssay Description:Expression and Purification of Beta-Lactamases. For his tag KPC-2 beta-lactamase, bacteria were grown overnight at 30 C with shaking in 50 mL LB brot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
University of South Florida

US Patent
LigandPNGBDBM426620(US10543221, Compound 72588 | US10543221, Formula )
Affinity DataKi:  1.00E+5nMAssay Description:Expression and Purification of Beta-Lactamases. For his tag KPC-2 beta-lactamase, bacteria were grown overnight at 30 C with shaking in 50 mL LB brot...More data for this Ligand-Target Pair
TargetUbiquitin-associated domain-containing protein 1(Human)
University of South Florida

US Patent
LigandPNGBDBM426627(US10543221, Compound 994943 | US10543221, Formula ...)
Affinity DataKi:  1.22E+5nMAssay Description:Expression and Purification of Beta-Lactamases. For his tag KPC-2 beta-lactamase, bacteria were grown overnight at 30 C with shaking in 50 mL LB brot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetUbiquitin-associated domain-containing protein 1(Human)
University of South Florida

US Patent
LigandPNGBDBM426623(US10543221, Compound 72674 | US10543221, Formula 9)
Affinity DataKi:  1.54E+5nMAssay Description:Expression and Purification of Beta-Lactamases. For his tag KPC-2 beta-lactamase, bacteria were grown overnight at 30 C with shaking in 50 mL LB brot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetUbiquitin-associated domain-containing protein 1(Human)
University of South Florida

US Patent
LigandPNGBDBM426629(US10543221, Compound 995016 | US10543221, Formula ...)
Affinity DataKi:  4.47E+5nMAssay Description:Expression and Purification of Beta-Lactamases. For his tag KPC-2 beta-lactamase, bacteria were grown overnight at 30 C with shaking in 50 mL LB brot...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetCatalase(Homo sapiens (Human))
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50541448(CHEMBL4633785)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of mammalian cathepsin A (unknown origin) using MCA-RPPGFSAFK-Dnp as substrate preincubated for 10 mins followed by substrate addition mea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50541448(CHEMBL4633785)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mammalian thrombin (unknown origin) using Benz-FVR-AMC as substrate preincubated for 10 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50541448(CHEMBL4633785)
Affinity DataIC50:  1.32E+5nMAssay Description:Inhibition of mammalian neutrophil elastase (unknown origin) using MeOSuc-AAVP-AMC as substrate preincubated for 10 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50541448(CHEMBL4633785)
Affinity DataIC50:  4.31E+5nMAssay Description:Inhibition of mammalian ECE-1 (unknown origin) using MCA-RPPGFSAFK(DNP)-OH as substrate preincubated for 10 mins followed by substrate addition measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin G(Homo sapiens (Human))
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50541448(CHEMBL4633785)
Affinity DataIC50:  6.66E+5nMAssay Description:Inhibition of mammalian cathepsin G (unknown origin) using Suc-AAPF-AMC as substrate preincubated for 10 mins followed by substrate addition measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B2(Homo sapiens)
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50541448(CHEMBL4633785)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of mammalian chymotrypsin (unknown origin) using Suc-AAPF-AMC as substrate preincubated for 10 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50541448(CHEMBL4633785)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of mammalian MMP-9 (unknown origin) using McaPLGLDpaAR-NH2 as substrate preincubated for 10 mins followed by substrate addition measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50541448(CHEMBL4633785)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of mammalian MMP-1 (unknown origin) using McaPLGLDpaAR-NH2 as substrate preincubated for 10 mins followed by substrate addition measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50541448(CHEMBL4633785)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of mammalian ACE-2 (unknown origin) using Mca-APK(Dnp) as substrate preincubated for 10 mins followed by substrate addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50541448(CHEMBL4633785)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of mammalian DPP9 (unknown origin) using Lys-Pro-AMC as substrate preincubated for 10 mins followed by substrate addition measured after 3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50541448(CHEMBL4633785)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of mammalian DPP8 (unknown origin) using Lys-Pro-AMC as substrate preincubated for 10 mins followed by substrate addition measured after 3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50541448(CHEMBL4633785)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of mammalian DPP7 (unknown origin) using H-Lys-Pro-AMC as substrate preincubated for 10 mins followed by substrate addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50541448(CHEMBL4633785)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of mammalian chymase (unknown origin) using Suc-AAPF-AMC as substrate preincubated for 10 mins followed by substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypsin(Homo sapiens (Human))
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50541448(CHEMBL4633785)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of mammalian trypsin (unknown origin) using N-Bz-R-AMC as substrate preincubated for 10 mins followed by substrate addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50541448(CHEMBL4633785)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of mammalian plasmin (unknown origin) using H-D-VLK-pNA as substrate preincubated for 10 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50541448(CHEMBL4633785)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of mammalian urokinase (unknown origin) using NGK-pNA as substrate preincubated for 10 mins followed by substrate addition measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed