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Found 1517 with Last Name = 'pisani' and Initial = 'l'
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50219206(Anthracen-9-yl (10H-phenothiazine-10yl) methanone,...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of human plasma BChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50219206(Anthracen-9-yl (10H-phenothiazine-10yl) methanone,...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of human erythrocytes BChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Universit£

Curated by ChEMBL
LigandPNGBDBM50424045(CHEMBL2314726)
Affinity DataKi:  8.60nMAssay Description:Mixed-type reversible inhibition of bovine acetylcholinesterase using S-acetylthiocholine as substrate incubated for 20 mins prior to substrate addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
University Of Bari "Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50585934(CHEMBL5082824)
Affinity DataKi:  13nMAssay Description:Competitive inhibition of human recombinant MAO-B expressed in supersomes using kynuramine as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataKi:  13nMAssay Description:Mixed type inhibition of human AChE using acetylthiocholineiodide as substrate measured for every 30 sec for 5 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50540764(CHEMBL4648322)
Affinity DataKi:  19nMAssay Description:Mixed type inhibition of human AChE using acetylthiocholineiodide as substrate measured for every 30 sec for 5 mins by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Universit£

Curated by ChEMBL
LigandPNGBDBM50342853(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-...)
Affinity DataKi:  21nMAssay Description:Inhibition of bovine AChE at 30 nM using S-acetylthiocholine as as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universit£

Curated by ChEMBL
LigandPNGBDBM50093085(CHEMBL3586582)
Affinity DataKi:  80nMAssay Description:Mixed type inhibition of electric eel AChE by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50424045(CHEMBL2314726)
Affinity DataKi:  93nMAssay Description:Mixed type inhibition of human AChE using acetylthiocholineiodide as substrate measured for every 30 sec for 5 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
University Of Bari "Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50532731(CHEMBL4571763)
Affinity DataKi:  93nMAssay Description:Binding affinity to recombinant human MAO-B expressed in Pichia pastoris assessed as inhibition constant using benzylamine as substrate by Michaelis-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50424045(CHEMBL2314726)
Affinity DataKi:  93.4nMAssay Description:Mixed type inhibition of human AChE using acetylthiocholineiodide as substrate measured for every 30 sec for 5 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
University Of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50524749(CHEMBL4538834)
Affinity DataKi:  98nMAssay Description:Mixed type inhibition of equine serum BChE assessed as Ki using butyrylthiocholine as substrate preincubated for 20 mins followed by substrate additi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
University Of Bari "Aldo Moro

Curated by ChEMBL
LigandPNGBDBM19188(7-(3-chlorobenzyloxy)-4-(methylamino)methyl-coumar...)
Affinity DataKi:  100nM ΔG°:  -40.0kJ/molepH: 7.5 T: 2°CAssay Description:MAO B activities were determined spectrophotometrically at 250 nm using benzylamine as substrate. Competitive Ki values were determined by measuring ...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universit£

Curated by ChEMBL
LigandPNGBDBM50093227(CHEMBL3586608)
Affinity DataKi:  100nMAssay Description:Mixed type inhibition of electric eel AChE by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
University Of Bari "Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50532731(CHEMBL4571763)
Affinity DataKi:  130nMAssay Description:Binding affinity to recombinant human MAO-B expressed in Pichia pastoris assessed as inhibition constant using benzylamine as substrate by Michaelis-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
University Of Bari "Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50532731(CHEMBL4571763)
Affinity DataKi:  190nMAssay Description:Binding affinity to recombinant human MAO-B expressed in Pichia pastoris assessed as inhibition constant using benzylamine as substrate by Michaelis-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
University Of Bari "Aldo Moro

Curated by ChEMBL
LigandPNGBDBM19189(7-(3-Chlorobenzyloxy)-4-carboxaldehyde-coumarin, 3...)
Affinity DataKi:  400nM ΔG°:  -36.5kJ/molepH: 7.5 T: 2°CAssay Description:MAO B activities were determined spectrophotometrically at 250 nm using benzylamine as substrate. Competitive Ki values were determined by measuring ...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
University Of Bari "Aldo Moro

Curated by ChEMBL
LigandPNGBDBM19187((2S)-2-[({4-[(3-fluorophenyl)methoxy]phenyl}methyl...)
Affinity DataKi:  450nM ΔG°:  -36.2kJ/molepH: 7.5 T: 2°CAssay Description:MAO B activities were determined spectrophotometrically at 250 nm using benzylamine as substrate. Competitive Ki values were determined by measuring ...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universit£

Curated by ChEMBL
LigandPNGBDBM50532731(CHEMBL4571763)
Affinity DataKi:  1.37E+3nMAssay Description:Mixed-type inhibition of electric eel AChE using S-acetylthiocholine as substrate preincubated for 20 mins followed by substrate addition measured fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universit£

Curated by ChEMBL
LigandPNGBDBM50532731(CHEMBL4571763)
Affinity DataKi:  1.37E+3nMAssay Description:Mixed-type inhibition of electric eel AChE using S-acetylthiocholine as substrate preincubated for 20 mins followed by substrate addition measured fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50585934(CHEMBL5082824)
Affinity DataKi:  2.00E+3nMAssay Description:Mixed type inhibition of human AChE by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
University Of Bari "Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50093227(CHEMBL3586608)
Affinity DataKi:  4.50E+3nMAssay Description:Tight binding inhibition of recombinant human MAO-B expressed in Pichia pastoris assessed as inhibition constant using benzylamine as substrate at 10...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University of Pavia

LigandPNGBDBM19189(7-(3-Chlorobenzyloxy)-4-carboxaldehyde-coumarin, 3...)
Affinity DataKi:  1.10E+4nM ΔG°:  -28.3kJ/molepH: 7.5 T: 2°CAssay Description:MAO A activities were determined spectrophotometrically at 316 nm using kynuramine as substrate. Competitive Ki values were determined by measuring i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University of Pavia

LigandPNGBDBM19188(7-(3-chlorobenzyloxy)-4-(methylamino)methyl-coumar...)
Affinity DataKi:  1.57E+4nM ΔG°:  -27.4kJ/molepH: 7.5 T: 2°CAssay Description:MAO A activities were determined spectrophotometrically at 316 nm using kynuramine as substrate. Competitive Ki values were determined by measuring i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University of Pavia

LigandPNGBDBM19187((2S)-2-[({4-[(3-fluorophenyl)methoxy]phenyl}methyl...)
Affinity DataKi:  3.65E+5nM ΔG°:  -19.6kJ/molepH: 7.5 T: 2°CAssay Description:MAO A activities were determined spectrophotometrically at 316 nm using kynuramine as substrate. Competitive Ki values were determined by measuring i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Universit£

Curated by ChEMBL
LigandPNGBDBM50262988(CHEMBL1200541 | N-(2-chlorobenzyl)-2-(2-(2-((2-chl...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of bovine AChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Universit£

Curated by ChEMBL
LigandPNGBDBM50262879(3-hydroxy-5-(4-(3-hydroxy-5-(trimethylammonio)phen...)
Affinity DataIC50:  0.170nMAssay Description:Inhibition of bovine AChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Universit£

Curated by ChEMBL
LigandPNGBDBM50262878(3-hydroxy-5-(3-(3-hydroxy-5-(trimethylammonio)phen...)
Affinity DataIC50:  0.490nMAssay Description:Inhibition of bovine AChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50523281(CHEMBL4583650)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human recombinant AChE using ATCh as substrate preincubated for 20 mins followed by substrate addition and measured for 3 mins by Ellma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Universita` Degli Studi Di Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM8611(4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonit...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human CYP11B2 expressed in Chinese hamster V79MZ cells using [1,2-3H]11-deoxycorticosterone/11-deoxycorticosteroneMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Bos taurus (bovine))
Universit£

Curated by ChEMBL
LigandPNGBDBM50262926(3-(4-(3,4-dimethyl-2-oxo-2H-chromen-7-yloxy)butoxy...)
Affinity DataIC50:  1nMAssay Description:Inhibition of bovine AChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  2nMAssay Description:Inhibition of acetylcholinesterase (unknown origin)More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Bos taurus (bovine))
Universit£

Curated by ChEMBL
LigandPNGBDBM50262880(3-(3-(3,4-dimethyl-2-oxo-2H-chromen-7-yloxy)propox...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of bovine AChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University of Pavia

LigandPNGBDBM15581(CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human recombinant MAOA expressed in microsomes of baculovirus-infected insect cell using kynuramine as substrate preincubated for 20 mi...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University of Pavia

LigandPNGBDBM15581(CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human recombinant MAOA expressed in microsomes of baculovirus-infected insect cell using kynuramine as substrate preincubated for 20 mi...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universita Degli Studi Di Bari

Curated by ChEMBL
LigandPNGBDBM19188(7-(3-chlorobenzyloxy)-4-(methylamino)methyl-coumar...)
Affinity DataIC50:  3nMAssay Description:Inhibition of MAO-B from Wistar rat brain by radioenzymatic assay in presence of human platelet rich plasmaMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universita Degli Studi Di Bari

Curated by ChEMBL
LigandPNGBDBM50038051(CHEMBL3094016)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universita Degli Studi Di Bari

Curated by ChEMBL
LigandPNGBDBM50038051(CHEMBL3094016)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universita Degli Studi Di Bari

Curated by ChEMBL
LigandPNGBDBM50038051(CHEMBL3094016)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B in brain mitochondrial homogenate assessed as 4-hydroxyquinoline by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University of Pavia

LigandPNGBDBM15581(CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of recombinant human MAO-A expressed in baculovirus infected insect cell microsomes using kynuramine as substrate measured after 30 mins b...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Bos taurus (bovine))
Universit£

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of bovine acetylcholinesterase using acetylcholine iodide as substrate incubated for 20 mins prior to substrate addition meausred after 3 ...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University of Pavia

LigandPNGBDBM15581(CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of human recombinant MAO-A using kynuramine substrate by spectrophotometric assayMore data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50339668(4-(1H-Imidazol-1-ylmethyl)-7-{[3-(trifluoromethoxy...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZh11B1 cells using [1,2-3H]-11-deoxycorticosterone substrate incubated for 25 mins by HPLC metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM10972((3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyr...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human plasma BChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM10972((3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyr...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human erythrocytes BChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universita Degli Studi Di Bari

Curated by ChEMBL
LigandPNGBDBM50038179(CHEMBL3094037)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universita Degli Studi Di Bari

Curated by ChEMBL
LigandPNGBDBM50038179(CHEMBL3094037)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B in brain mitochondrial homogenate assessed as 4-hydroxyquinoline by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
University Of Bari "Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50093335(CHEMBL3586611)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of human recombinant MAO-B using kynuramine substrate by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universita Degli Studi Di Bari

Curated by ChEMBL
LigandPNGBDBM50038156(CHEMBL3093993)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universita Degli Studi Di Bari

Curated by ChEMBL
LigandPNGBDBM50038156(CHEMBL3093993)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B in brain mitochondrial homogenate assessed as 4-hydroxyquinoline by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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