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Found 1202 with Last Name = 'pokross' and Initial = 'm'
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM164638(BDBM166759 | US10604504, Example 223 | US11623921,...)
Affinity DataKi:  116nMAssay Description:Inhibition of His-tagged BTK (unknown origin) after 1.5 hrs by HTRF analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataKi:  425nMAssay Description:Inhibition of His-tagged BTK (unknown origin) after 1.5 hrs by HTRF analysisMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13433(N-[(3S)-2-[(tert-butoxy)carbonyl]-3-(methylcarbamo...)
Affinity DataKi:  2.40E+4nM ΔG°:  -26.1kJ/molepH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13529(N-(1-methyl-3-phenyl-1H-pyrazol-5-yl)sulfamic acid...)
Affinity DataKi: >5.00E+5nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM166831(US10604504, Example 242 | US11623921, Example 242 ...)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of recombinant human BTK using fluoresceinated peptide as substrate after 60 mins fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of recombinant human BTK using fluoresceinated peptide as substrate after 60 mins fluorescence assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM164638(BDBM166759 | US10604504, Example 223 | US11623921,...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of recombinant human BTK using fluoresceinated peptide as substrate after 60 mins fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM165319(US10604504, Example 115 | US11623921, Example 115 ...)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of recombinant human BTK using fluoresceinated peptide as substrate after 60 mins fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50613418(CHEMBL5268185)
Affinity DataIC50:  0.170nMAssay Description:Inhibition of GST tagged GSK-3alpha (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095584(4-(2-Benzyloxy-3-phenyl-propionylamino)-1-(4-metho...)
Affinity DataIC50:  0.200nMAssay Description:In vitro inhibitory activity against matrix metalloproteinase -2 (gelatinase-A)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50613417(CHEMBL5290300)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of GST tagged GSK-3alpha (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50074676(CHEMBL3410091)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of GSK3beta (unknown origin) activity by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM164638(BDBM166759 | US10604504, Example 223 | US11623921,...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of BTK in human peripheral B cells assessed as reduction in CD86 surface expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095576(1-(4-Butoxy-benzenesulfonyl)-4-(2,5-dioxo-3-propyl...)
Affinity DataIC50:  0.300nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloproteinase-13 (collagenase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM164638(BDBM166759 | US10604504, Example 223 | US11623921,...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of BTK in human PBMC assessed as reduction in TNFalpha expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095581(4-(2-Benzyloxy-propionylamino)-1-(4-methoxy-benzen...)
Affinity DataIC50:  0.300nMAssay Description:In vitro inhibitory activity against matrix metalloproteinase -2 (gelatinase-A)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095538(1-(4-Butoxy-benzenesulfonyl)-4-(3-methyl-2,5-dioxo...)
Affinity DataIC50:  0.300nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloproteinase-13 (collagenase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095573(4-(3-Methyl-2,5-dioxo-imidazolidin-1-yl)-1-(4-prop...)
Affinity DataIC50:  0.300nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloproteinase-13 (collagenase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50511306(CHEMBL4470115)
Affinity DataIC50:  0.300nMAssay Description:Displacement of fluorescein labeled probe from full length human GST-tagged RIPK3 expressed in Sf9 cells incubated for 60 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50613415(CHEMBL5273872)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of GST tagged GSK-3alpha (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50074675(CHEMBL3410092)
Affinity DataIC50:  0.370nMAssay Description:Inhibition of GSK3beta (unknown origin) activity by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20655(N-benzyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]a...)
Affinity DataIC50:  0.400nM EC50:  9.60nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095558(4-(3-Allyl-2,5-dioxo-imidazolidin-1-yl)-1-(4-propo...)
Affinity DataIC50:  0.400nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloproteinase-13 (collagenase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095576(1-(4-Butoxy-benzenesulfonyl)-4-(2,5-dioxo-3-propyl...)
Affinity DataIC50:  0.400nMAssay Description:In vitro inhibitory activity against matrix metalloproteinase -2 (gelatinase-A)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095546(4-Piperidin-1-yl-1-(4-propoxy-benzenesulfonyl)-pyr...)
Affinity DataIC50:  0.400nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloproteinase-13 (collagenase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095560(4-(3-Allyl-2,5-dioxo-imidazolidin-1-yl)-1-(4-butox...)
Affinity DataIC50:  0.400nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloproteinase-13 (collagenase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095554(4-(1,1-Dioxo-1lambda*6*-isothiazolidin-2-yl)-1-(4-...)
Affinity DataIC50:  0.400nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloproteinase-13 (collagenase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50613407(CHEMBL5269649)
Affinity DataIC50:  0.450nMAssay Description:Inhibition of GST tagged GSK-3alpha (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50074677(CHEMBL3410090)
Affinity DataIC50:  0.450nMAssay Description:Inhibition of GSK3beta (unknown origin) activity by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095540(4-[(2-Hydroxy-4-phenyl-butyryl)-propyl-amino]-1-(4...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of matrix metalloproteinase-13 (collagenase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095579(1-(4-Methoxy-benzenesulfonyl)-4-(3-methyl-2,5-diox...)
Affinity DataIC50:  0.5nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloproteinase-13 (collagenase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095580(4-(Methanesulfonyl-methyl-amino)-1-(4-methoxy-benz...)
Affinity DataIC50:  0.5nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloproteinase-13 (collagenase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM165320(US10604504, Example 116 | US11623921, Example 116 ...)
Affinity DataIC50:  0.520nMAssay Description:Inhibition of recombinant human BTK using fluoresceinated peptide as substrate after 60 mins fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095541(1-(4-Butoxy-benzenesulfonyl)-4-morpholin-4-yl-pyrr...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of matrix metalloproteinase-13 (collagenase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095540(4-[(2-Hydroxy-4-phenyl-butyryl)-propyl-amino]-1-(4...)
Affinity DataIC50:  0.600nMAssay Description:In vitro inhibitory activity against matrix metalloproteinase -2 (gelatinase-A)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM165463(US10604504, Example 141 | US11623921, Example 141 ...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of recombinant human BTK using fluoresceinated peptide as substrate after 60 mins fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50613413(CHEMBL5265990)
Affinity DataIC50:  0.660nMAssay Description:Inhibition of GST tagged GSK-3alpha (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095593(1-(4-Butoxy-benzenesulfonyl)-4-(2-methoxy-acetylam...)
Affinity DataIC50:  0.700nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloproteinase-13 (collagenase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50573689(CHEMBL4857123)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of recombinant human GST-Xa-tagged-AAK1 (30 to 330 residues) expressed in baculovirus expression system using (5 -FAM)-Aha-KEEQSQITSQVTGQI...More data for this Ligand-Target Pair
In DepthDetails PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095547(4-[(2-Hydroxy-propionyl)-propyl-amino]-1-(4-methox...)
Affinity DataIC50:  0.700nMAssay Description:In vitro inhibitory activity against matrix metalloproteinase -2 (gelatinase-A)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095567((1N)-4-N-BUTOXYPHENYLSULFONYL-(2R)-N-HYDROXYCARBOX...)
Affinity DataIC50:  0.700nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloproteinase-13 (collagenase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095578(4-Morpholin-4-yl-1-(4-pentyl-benzenesulfonyl)-pyrr...)
Affinity DataIC50:  0.700nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloproteinase-13 (collagenase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095570(4-(3-Methyl-2,5-dioxo-imidazolidin-1-yl)-1-[4-(pyr...)
Affinity DataIC50:  0.700nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloproteinase-13 (collagenase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50613402(CHEMBL5270885)
Affinity DataIC50:  0.740nMAssay Description:Inhibition of GST tagged GSK-3alpha (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095558(4-(3-Allyl-2,5-dioxo-imidazolidin-1-yl)-1-(4-propo...)
Affinity DataIC50:  0.800nMAssay Description:In vitro inhibitory activity against matrix metalloproteinase -2 (gelatinase-A)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095569(4-(Methanesulfonyl-propyl-amino)-1-(4-methoxy-benz...)
Affinity DataIC50:  0.800nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloproteinase-13 (collagenase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095592(4-Methanesulfonylamino-1-[4-(pyridin-4-yloxy)-benz...)
Affinity DataIC50:  0.800nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloproteinase-13 (collagenase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095567((1N)-4-N-BUTOXYPHENYLSULFONYL-(2R)-N-HYDROXYCARBOX...)
Affinity DataIC50:  0.800nMAssay Description:In vitro inhibitory activity against matrix metalloproteinase -2 (gelatinase-A)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095589(1-(4-Butoxy-benzenesulfonyl)-4-(2-hydroxy-3-methyl...)
Affinity DataIC50:  0.800nMAssay Description:In vitro inhibitory activity against human recombinant matrix metalloproteinase-13 (collagenase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50095569(4-(Methanesulfonyl-propyl-amino)-1-(4-methoxy-benz...)
Affinity DataIC50:  0.800nMAssay Description:In vitro inhibitory activity against matrix metalloproteinase -2 (gelatinase-A)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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