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Found 169 with Last Name = 'prins' and Initial = 'tj'
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065621(CHEMBL94688 | [(S)-1-((S)-1-{(S)-3-Carbamoyl-1-[2-...)
Affinity DataKi:  30nMAssay Description:Catalytic rate constant (Kobs/[I]) of the compound was evaluated against human rhinovirus (HRV) serotype 14 3C Protease (3CP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408099(CHEMBL57087)
Affinity DataKi:  120nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408102(CHEMBL55646)
Affinity DataKi:  150nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408104(CHEMBL292238)
Affinity DataKi:  200nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408110(CHEMBL293284)
Affinity DataKi:  220nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408096(CHEMBL301025)
Affinity DataKi:  350nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408101(CHEMBL293519)
Affinity DataKi:  370nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408094(CHEMBL59256)
Affinity DataKi:  390nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408105(CHEMBL294146)
Affinity DataKi:  550nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408100(CHEMBL57674)
Affinity DataKi:  570nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408103(CHEMBL293294)
Affinity DataKi:  790nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408107(CHEMBL56789)
Affinity DataKi:  6.50E+3nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408097(CHEMBL56270)
Affinity DataKi:  7.20E+3nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408109(CHEMBL54055)
Affinity DataKi:  8.40E+3nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408106(CHEMBL56927)
Affinity DataKi:  1.40E+4nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408098(CHEMBL298828)
Affinity DataKi:  2.40E+4nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408095(CHEMBL292166)
Affinity DataKi:  6.70E+4nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408108(CHEMBL299276)
Affinity DataKi:  8.30E+4nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319027((+/-)-3-(amino(2-(2-aminopyrimidin-4-yl)-3-methylb...)
Affinity DataIC50:  10nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319031((+/-)-4-(5-(amino(phenyl)methyl)-3-methylbenzo[b]t...)
Affinity DataIC50:  20nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319035((+/-)-4-(5-(1-aminobutyl)-3-methylbenzo[b]thiophen...)
Affinity DataIC50:  20nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319021(3-((2-(2-aminopyrimidin-4-yl)-3-methylbenzo[b]thio...)
Affinity DataIC50:  20nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319025(3-(2-(2-aminopyrimidin-4-yl)-3-methylbenzo[b]thiop...)
Affinity DataIC50:  20nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319026((+/-)-4-(5-(amino(3-methoxyphenyl)methyl)-3-methyl...)
Affinity DataIC50:  20nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM14028((S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]...)
Affinity DataIC50:  30nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319037((+/-)-4-(5-(1-amino-3-methylbutyl)-3-methylbenzo[b...)
Affinity DataIC50:  30nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319005((R)-4-(1-aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4...)
Affinity DataIC50:  30nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319029((+/-)--4-(5-(amino(3-chlorophenyl)methyl)-3-methyl...)
Affinity DataIC50:  30nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319030((+/-)--4-(5-(amino(m-tolyl)methyl)-3-methylbenzo[b...)
Affinity DataIC50:  50nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319022(3-((2-(2-aminopyrimidin-4-yl)-3-methylbenzo[b]thio...)
Affinity DataIC50:  60nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319036((+/-)-4-(5-(1-amino-2-methylpropyl)-3-methylbenzo[...)
Affinity DataIC50:  60nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319028((+/-)--4-(5-(amino(4-methoxyphenyl)methyl)-3-methy...)
Affinity DataIC50:  90nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319034((+/-)-4-(5-(1-aminopropyl)-3-methylbenzo[b]thiophe...)
Affinity DataIC50:  140nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319018(4-(5-(3-methoxybenzyl)-3-methylbenzo[b]thiophen-2-...)
Affinity DataIC50:  230nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319024(3-(2-(2-aminopyrimidin-4-yl)-3-methylbenzo[b]thiop...)
Affinity DataIC50:  360nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319033((+/-)-4-(5-(1-aminoethyl)-3-methylbenzo[b]thiophen...)
Affinity DataIC50:  400nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319016(4-(5-benzyl-3-methylbenzo[b]thiophen-2-yl)pyrimidi...)
Affinity DataIC50:  580nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319007(4-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-N-methy...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319006(4-(5-chloro-3-methylbenzo[b]thiophen-2-yl)pyrimidi...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319032(4-(5-(aminomethyl)-3-methylbenzo[b]thiophen-2-yl)p...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319014(4-(3-methylbenzo[b]thiophen-2-yl)pyrimidin-2-amine...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319015(4-(3-methyl-5-phenylbenzo[b]thiophen-2-yl)pyrimidi...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319012(4-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1H-pyrr...)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319019(4-(5-(4-methoxybenzyl)-3-methylbenzo[b]thiophen-2-...)
Affinity DataIC50:  7.20E+3nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319010(4-(5-chloro-3-methylbenzo[b]thiophen-2-yl)pyridin-...)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319020(4-(3-methyl-5-(3-(trifluoromethyl)benzyl)benzo[b]t...)
Affinity DataIC50:  8.60E+3nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319017(4-(5-(2-methoxybenzyl)-3-methylbenzo[b]thiophen-2-...)
Affinity DataIC50:  9.70E+3nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319013(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1H-pyrr...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319023(CHEMBL1084792 | methyl 3-((2-(2-aminopyrimidin-4-y...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319009(6-(5-chloro-3-methylbenzo[b]thiophen-2-yl)pyrimidi...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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