Compile Data Set for Download or QSAR
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Found 242 with Last Name = 'prugh' and Initial = 'jd'
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012229(5-Thiomorpholin-4-ylmethyl-thieno[2,3-b]thiophene-...)
Affinity DataKi:  0.440nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012211(5-{[Bis-(2-methoxy-ethyl)-amino]-methyl}-thieno[3,...)
Affinity DataKi:  0.950nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012231(5-Morpholin-4-ylmethyl-thieno[2,3-b]thiophene-2-su...)
Affinity DataKi:  1nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004551(5-Morpholin-4-ylmethyl-thieno[2,3-b]furan-2-sulfon...)
Affinity DataKi:  1.20nMAssay Description:Compound was evaluated for the inhibition of dansylamide at human carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012209(5-{[Bis-(2-methoxy-ethyl)-amino]-methyl}-thieno[2,...)
Affinity DataKi:  1.34nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012227(5-{[Bis-(1-methyl-2-oxo-ethyl)-amino]-methyl}-thie...)
Affinity DataKi:  1.49nMAssay Description:The compound was tested for in vitro binding affinity against human Carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012208(5-{1-[[2-(2-Methoxy-ethoxy)-ethyl]-(2-methoxy-ethy...)
Affinity DataKi:  1.54nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012207(5-{[[2-(2-Methoxy-ethoxy)-ethyl]-(2-methoxy-ethyl)...)
Affinity DataKi:  1.58nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012225(5-[(2-Fluoro-ethylamino)-methyl]-thieno[2,3-b]thio...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012232(5-[(2-Methylsulfanyl-ethylamino)-methyl]-thieno[2,...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012217(5-Sulfamoyl-thieno[2,3-b]thiophene-2-carboxylic ac...)
Affinity DataKi:  2.39nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012215(5-{[Bis-(2-hydroxy-ethyl)-amino]-methyl}-thieno[2,...)
Affinity DataKi:  2.60nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004553(5-{[Bis-(2-methoxy-ethyl)-amino]-methyl}-thieno[2,...)
Affinity DataKi:  2.60nMAssay Description:Compound was evaluated for the inhibition of dansylamide at human carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012220(5-(Isobutylamino-methyl)-thieno[3,2-b]thiophene-2-...)
Affinity DataKi:  2.70nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012236(5-({Bis-[2-(2-methoxy-ethoxy)-ethyl]-amino}-methyl...)
Affinity DataKi:  2.77nMAssay Description:The compound was tested for in vitro binding affinity against human Carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012219(5-[(2-Methoxy-ethylamino)-methyl]-thieno[3,2-b]thi...)
Affinity DataKi:  3nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012221(5-{1-[2-(2-Methoxy-ethoxy)-ethylamino]-ethyl}-thie...)
Affinity DataKi:  3nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012210(5-Sulfamoyl-thieno[2,3-b]thiophene-2-carboxylic ac...)
Affinity DataKi:  3.40nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004556(5-[(2-Fluoro-ethylamino)-methyl]-thieno[2,3-b]fura...)
Affinity DataKi:  3.40nMAssay Description:Compound was evaluated for the inhibition of dansylamide at human carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012226(5-(1-Oxo-1lambda*4*-thiomorpholin-4-ylmethyl)-thie...)
Affinity DataKi:  3.40nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004554(5-{[[2-(2-Methoxy-ethoxy)-ethyl]-(2-methoxy-ethyl)...)
Affinity DataKi:  3.60nMAssay Description:Compound was evaluated for the inhibition of dansylamide at human carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012213(5-[(2-Methoxy-ethylamino)-methyl]-thieno[2,3-b]thi...)
Affinity DataKi:  4nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012218(5-(Isobutylamino-methyl)-thieno[2,3-b]thiophene-2-...)
Affinity DataKi:  4nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012233(5-Sulfamoyl-thieno[2,3-b]thiophene-2-carboxylic ac...)
Affinity DataKi:  4nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012224(5-[(2-Methanesulfonyl-ethylamino)-methyl]-thieno[2...)
Affinity DataKi:  4.80nMAssay Description:The compound was tested for in vitro binding affinity against human Carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012234(5-Sulfamoyl-thieno[2,3-b]thiophene-2-carboxylic ac...)
Affinity DataKi:  6nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012235(5-[(2-Methanesulfinyl-ethylamino)-methyl]-thieno[2...)
Affinity DataKi:  6nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012230(5-[(Cyclopropylmethyl-amino)-methyl]-thieno[2,3-b]...)
Affinity DataKi:  7nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012223(5-{2-(4-Fluoro-phenyl)-1-[[2-(2-methoxy-ethoxy)-et...)
Affinity DataKi:  7nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004552(5-(Isobutylamino-methyl)-thieno[2,3-b]furan-2-sulf...)
Affinity DataKi:  7.40nMAssay Description:Compound was evaluated for the inhibition of dansylamide at human carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004555(5-{[(Pyridin-2-ylmethyl)-amino]-methyl}-thieno[2,3...)
Affinity DataKi:  8.20nMAssay Description:Compound was evaluated for the inhibition of dansylamide at human carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012214(5-Sulfamoyl-thieno[2,3-b]thiophene-2-carboxylic ac...)
Affinity DataKi:  9nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012216(5-Sulfamoyl-thieno[2,3-b]thiophene-2-carboxylic ac...)
Affinity DataKi:  11nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012222(5-Methylaminomethyl-thieno[3,2-b]thiophene-2-sulfo...)
Affinity DataKi:  12nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004550(5-Ethylaminomethyl-thieno[2,3-b]furan-2-sulfonic a...)
Affinity DataKi:  19nMAssay Description:Compound was evaluated for the inhibition of dansylamide at human carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012212(5-Methylaminomethyl-thieno[2,3-b]thiophene-2-sulfo...)
Affinity DataKi:  21nMAssay Description:The compound was tested for in vitro binding affinity against human Carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004557(5-Methylaminomethyl-thieno[2,3-b]furan-2-sulfonic ...)
Affinity DataKi:  32nMAssay Description:Compound was evaluated for the inhibition of dansylamide at human carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012228(5-(tert-Butylamino-methyl)-thieno[2,3-b]thiophene-...)
Affinity DataKi:  37nMAssay Description:In vitro binding affinity against human carbonic anhydrase IIChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50078436((S)-2-(2-Ethoxy-ethanesulfonylamino)-3-{[5-(2-pipe...)
Affinity DataIC50:  7nMAssay Description:The compound was tested in vivo for the inhibition of aggregation of human gel-filtered platelets(GFP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50078433((S)-2-Benzenesulfonylamino-3-{[5-(2-piperidin-4-yl...)
Affinity DataIC50:  7nMAssay Description:The compound was tested in vivo for the inhibition of aggregation of human gel-filtered platelets(GFP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50058239((S)-3-{[4-Oxo-5-(2-piperidin-4-yl-ethyl)-5,6,7,8-t...)
Affinity DataIC50:  8nMAssay Description:Inhibition of aggregation of human gel-filtered platelets measured by light transmittance method at 37 degrees C.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50078437((S)-3-{[5-(2-Piperidin-4-yl-ethyl)-thieno[2,3-b]th...)
Affinity DataIC50:  8nMAssay Description:The compound was tested in vivo for the inhibition of aggregation of human gel-filtered platelets(GFP)More data for this Ligand-Target Pair
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50091729((S)-4-Hydroxy-3-{[3-oxo-2-(2-piperidin-4-yl-ethyl)...)
Affinity DataIC50:  8nMAssay Description:Competition with [1251]L-692,884 for binding to purified alpha IIb/beta3 integrin, activated by coating onto yttrium silicate scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50091735((S)-2-Benzenesulfonylamino-3-{[3-oxo-2-(2-piperidi...)
Affinity DataIC50:  8nMAssay Description:Inhibition of aggregation of human gel-filtered platelets measured by light transmittance method at 37 degrees C.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50078440((S)-2-Benzenesulfonylamino-3-{[5-(2-piperidin-4-yl...)
Affinity DataIC50:  8nMAssay Description:Competition with [1251]L-692,884 for binding to purified alpha IIb/beta3 integrin, activated by coating onto yttrium silicate scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50078440((S)-2-Benzenesulfonylamino-3-{[5-(2-piperidin-4-yl...)
Affinity DataIC50:  8nMAssay Description:The compound was tested in vivo for the inhibition of aggregation of human gel-filtered platelets(GFP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50091731((S)-3-{2-[(R)-2-Oxo-1-(2-piperidin-4-yl-ethyl)-pip...)
Affinity DataIC50:  9nMAssay Description:Binding affinity to resting form of alpha IIb/beta3 integrin by flow cytometry using fluorescein ligand L-726,745 displacement from human platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50078431((S)-3-{[5-(2-Piperidin-4-yl-ethyl)-thieno[2,3-b]th...)
Affinity DataIC50:  9nMAssay Description:The compound was tested in vivo for the inhibition of aggregation of human gel-filtered platelets(GFP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50078445((S)-2-(Butane-1-sulfonylamino)-3-{[5-(2-piperidin-...)
Affinity DataIC50:  10nMAssay Description:The compound was tested in vivo for the inhibition of aggregation of human gel-filtered platelets(GFP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50091733((S)-2-Benzenesulfonylamino-3-{[5-(2-piperidin-4-yl...)
Affinity DataIC50:  10nMAssay Description:Competition with [1251]L-692,884 for binding to purified alpha IIb/beta3 integrin, activated by coating onto yttrium silicate scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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