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Found 112 with Last Name = 'pyatkin' and Initial = 'i'
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231755(6,6-dimethyl-2-phenylethynyl-7,8-dihydro-6H-quinol...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231728(5-methoxy-2-phenylethynyl-5,6,7,8-tetrahydro-quino...)
Affinity DataKi:  139nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231738(7,7-dimethyl-2-pyridin-2-ylethynyl-7,8-dihydro-6H-...)
Affinity DataKi:  210nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231741(2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one | CH...)
Affinity DataKi:  800nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231751(6-phenylethynyl-nicotinic acid methyl ester | CHEM...)
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231753(2-phenylethynyl-5,6,7,8-tetrahydro-quinoline | CHE...)
Affinity DataKi:  1.50E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231721(2-pyridin-2-ylethynyl-7,8-dihydro-6H-quinolin-5-on...)
Affinity DataKi:  2.36E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231747((R)-2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-...)
Affinity DataKi:  4.71E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231719(2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-ol |...)
Affinity DataKi:  7.60E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231759((S)-2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-...)
Affinity DataKi:  9.28E+3nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231750((3-ethyl-2-methylquinolin-6-yl)(4-methoxycyclohexy...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231744(CHEMBL399160 | NPS 2390 | quinoxaline-2-carboxylic...)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231749(6-ethyl-5-methyl-3-(1,2,4,5-tetrahydrobenzo[d]azep...)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50231755(6,6-dimethyl-2-phenylethynyl-7,8-dihydro-6H-quinol...)
Affinity DataIC50:  23nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231755(6,6-dimethyl-2-phenylethynyl-7,8-dihydro-6H-quinol...)
Affinity DataIC50:  23nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438277(CHEMBL2408412)
Affinity DataIC50:  28nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438295(CHEMBL2408568)
Affinity DataIC50:  34nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438289(CHEMBL2408574)
Affinity DataIC50:  43nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231748(CHEMBL253347 | quinoline-3-carboxylic acid adamant...)
Affinity DataIC50:  52nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438278(CHEMBL2408411)
Affinity DataIC50:  68nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231758(2-cyclopentylamino-7,7-dimethyl-5-oxo-5,6,7,8-tetr...)
Affinity DataIC50:  78nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231728(5-methoxy-2-phenylethynyl-5,6,7,8-tetrahydro-quino...)
Affinity DataIC50:  80nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438294(CHEMBL2408569)
Affinity DataIC50:  83nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438298(CHEMBL2408565)
Affinity DataIC50:  85nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231757(2-[4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl...)
Affinity DataIC50:  110nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438288(CHEMBL2408575)
Affinity DataIC50:  111nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438305(CHEMBL2408585)
Affinity DataIC50:  120nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438291(CHEMBL2408572)
Affinity DataIC50:  125nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231743(7,7-dimethyl-5-oxo-2-(4-phenyl-piperazin-1-yl)-5,6...)
Affinity DataIC50:  130nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438293(CHEMBL2408570)
Affinity DataIC50:  157nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231764(2-[4-(4-fluoro-phenyl)-piperazin-1-yl]-7,7-dimethy...)
Affinity DataIC50:  160nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438298(CHEMBL2408565)
Affinity DataIC50:  170nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438298(CHEMBL2408565)
Affinity DataIC50:  170nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438300(CHEMBL2408563)
Affinity DataIC50:  245nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438303(CHEMBL2408561)
Affinity DataIC50:  272nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231752(CHEMBL399161 | quinoline-2-carboxylic acid adamant...)
Affinity DataIC50:  440nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438281(CHEMBL2408408)
Affinity DataIC50:  452nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438301(CHEMBL1389853)
Affinity DataIC50:  492nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438299(CHEMBL2408564)
Affinity DataIC50:  493nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438309(CHEMBL2408582)
Affinity DataIC50:  496nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50231753(2-phenylethynyl-5,6,7,8-tetrahydro-quinoline | CHE...)
Affinity DataIC50:  510nMAssay Description:Displacement of [3H]MPEP from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438292(CHEMBL2408571)
Affinity DataIC50:  598nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438290(CHEMBL2408573)
Affinity DataIC50:  721nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438304(CHEMBL2408413)
Affinity DataIC50:  722nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Institute Of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50003013(CHEMBL401270)
Affinity DataIC50: <1.00E+3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438283(CHEMBL2408406)
Affinity DataIC50:  1.04E+3nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438286(CHEMBL2408577)
Affinity DataIC50:  1.12E+3nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438287(CHEMBL2408576)
Affinity DataIC50:  1.13E+3nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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