Compile Data Set for Download or QSAR
maximum 50k data
Found 58 with Last Name = 'rafidi' and Initial = 'k'
LigandPNGBDBM50336407(4-amino-2,6-dimethyl-N-(1H-pyrrolo[2,3-b]pyridin-5...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336406(4-amino-2,6-dimethyl-N-(6-methylpyridin-3-yl)quina...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336405(4-amino-2-methyl-N-(6-methylpyridin-3-yl)quinazoli...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336410(4-amino-N-(6-methoxypyridin-3-yl)-2,6-dimethylquin...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327904(2-amino-4-methyl-6-(1H-pyrazol-3-yl)-8-(tetrahydro...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327907(CHEMBL1257295 | trans-2-amino-8-(4-hydroxycyclohex...)
Affinity DataKi:  0.850nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336418(4-amino-2-methyl-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)...)
Affinity DataKi:  1nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336404(4-amino-2,6-dimethyl-N-(1H-pyrazol-5-yl)quinazolin...)
Affinity DataKi:  3nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327906(2-amino-4-methyl-6-(6-methylpyridin-3-yl)-8-(tetra...)
Affinity DataKi:  5nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327894(2-amino-8-isopropyl-6-(6-methoxypyridin-3-yl)-4-me...)
Affinity DataKi:  5nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336408(4-amino-2,6-dimethyl-N-(1H-pyrazol-4-yl)quinazolin...)
Affinity DataKi:  5nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336418(4-amino-2-methyl-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)...)
Affinity DataKi:  5nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327903(CHEMBL1258910 | trans-2-amino-8-(4-(2-hydroxyethox...)
Affinity DataKi:  5.11nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327897(2-amino-8-isopropyl-4-methyl-6-(1H-pyrazol-5-yl)pt...)
Affinity DataKi:  6nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336420(4-amino-2-methyl-N-(1H-pyrazol-4-yl)quinazoline-8-...)
Affinity DataKi:  6nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327905(CHEMBL1257177 | trans-2-amino-8-((1r,4r)-4-hydroxy...)
Affinity DataKi:  6.80nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336404(4-amino-2,6-dimethyl-N-(1H-pyrazol-5-yl)quinazolin...)
Affinity DataKi:  7nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327896(2-amino-4-methyl-8-(1-methylethyl)-6-(1H-pyrazol-4...)
Affinity DataKi:  9nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336417(4-amino-N-(6-(dimethylamino)pyridin-3-yl)-2,6-dime...)
Affinity DataKi:  12nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336412(4-amino-2-methyl-6-(morpholinomethyl)-N-(1H-pyrazo...)
Affinity DataKi:  13nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336412(4-amino-2-methyl-6-(morpholinomethyl)-N-(1H-pyrazo...)
Affinity DataKi:  15nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336407(4-amino-2,6-dimethyl-N-(1H-pyrrolo[2,3-b]pyridin-5...)
Affinity DataKi:  17nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327901(2-amino-8-isopropyl-6-(2-methoxypyrimidin-5-yl)-4-...)
Affinity DataKi:  18nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336420(4-amino-2-methyl-N-(1H-pyrazol-4-yl)quinazoline-8-...)
Affinity DataKi:  21nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327900(2-amino-8-isopropyl-6-(6-methoxypyridin-3-yl)-4-me...)
Affinity DataKi:  30nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336405(4-amino-2-methyl-N-(6-methylpyridin-3-yl)quinazoli...)
Affinity DataKi:  31nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336415(4-amino-N-(6-(dimethylamino)pyridin-3-yl)-2-methyl...)
Affinity DataKi:  54nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336406(4-amino-2,6-dimethyl-N-(6-methylpyridin-3-yl)quina...)
Affinity DataKi:  66nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336408(4-amino-2,6-dimethyl-N-(1H-pyrazol-4-yl)quinazolin...)
Affinity DataKi:  84nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336416(4-amino-N-(6-(dimethylamino)pyridin-3-yl)-2,7-dime...)
Affinity DataKi:  100nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336421(4-amino-2,7-dimethyl-N-(1H-pyrazol-4-yl)quinazolin...)
Affinity DataKi:  100nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336409(4-amino-N-(6-methoxypyridin-3-yl)-2,7-dimethylquin...)
Affinity DataKi:  100nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327898(2-amino-8-isopropyl-4-methyl-6-(1H-1,2,3-triazol-5...)
Affinity DataKi:  113nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336417(4-amino-N-(6-(dimethylamino)pyridin-3-yl)-2,6-dime...)
Affinity DataKi:  162nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336413(4-amino-6-((dimethylamino)methyl)-2-methyl-N-(1H-p...)
Affinity DataKi:  188nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336419(4-amino-2,7-dimethyl-N-(1H-pyrrolo[2,3-b]pyridin-5...)
Affinity DataKi:  216nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336410(4-amino-N-(6-methoxypyridin-3-yl)-2,6-dimethylquin...)
Affinity DataKi:  265nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336419(4-amino-2,7-dimethyl-N-(1H-pyrrolo[2,3-b]pyridin-5...)
Affinity DataKi:  631nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327902(2-amino-8-isopropyl-6-(2-methoxypyridin-4-yl)-4-me...)
Affinity DataKi:  947nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336411(4-amino-2,7-dimethyl-N-(1H-pyrazol-5-yl)quinazolin...)
Affinity DataKi:  984nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336409(4-amino-N-(6-methoxypyridin-3-yl)-2,7-dimethylquin...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336415(4-amino-N-(6-(dimethylamino)pyridin-3-yl)-2-methyl...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336413(4-amino-6-((dimethylamino)methyl)-2-methyl-N-(1H-p...)
Affinity DataKi:  1.33E+3nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336414(4-amino-2,7-dimethyl-N-(6-methylpyridin-3-yl)quina...)
Affinity DataKi:  3.25E+3nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327899(2-amino-8-isopropyl-6-(2-methoxypyridin-3-yl)-4-me...)
Affinity DataKi:  3.94E+3nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327895(2-amino-8-isopropyl-4-methoxy-6-(6-methoxypyridin-...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336414(4-amino-2,7-dimethyl-N-(6-methylpyridin-3-yl)quina...)
Affinity DataKi:  4.55E+3nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336411(4-amino-2,7-dimethyl-N-(1H-pyrazol-5-yl)quinazolin...)
Affinity DataKi:  4.55E+3nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327907(CHEMBL1257295 | trans-2-amino-8-(4-hydroxycyclohex...)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of AKT in human BT20 cells assessed as inhibition of S473 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327903(CHEMBL1258910 | trans-2-amino-8-(4-(2-hydroxyethox...)
Affinity DataIC50:  5.74nMAssay Description:Inhibition of AKT in human BT20 cells assessed as inhibition of S473 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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