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Found 79 with Last Name = 'rahali' and Initial = 'h'
TargetGenome polyprotein(Hepatitis C virus)
Idenix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142916((1S,4R,6S,14S,18R)-14-Cyclopentyloxycarbonylamino-...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Idenix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50023510(CHEMBL3326826)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191171(2-(4-flurophenyl)-1,10b-dihydro-benzo[e]pyrazolo[1...)
Affinity DataIC50:  1.80nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Idenix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50023579(CHEMBL3326830)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Idenix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50023508(CHEMBL3326539)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Idenix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50023578(CHEMBL3326829)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191182(1-propyl-4'-(pyridin-4-yl)-8'-oxa-5',6'-diazaspiro...)
Affinity DataIC50:  15nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Idenix An Msd

Curated by ChEMBL
LigandPNGBDBM50138406(3TC Triphosphate | CHEMBL1230 | LAMIVUDINE | Lamiv...)
Affinity DataIC50:  15nMAssay Description:Inhibition of full-length wild-type HIV1 reverse transcriptase expressed in Escherichia coli BL21(DE3) pre-incubated for 30 mins before addition of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191179(1-(2-phenylethyl)-4'-(pyridin-4-yl)-8'-oxa-5',6'-d...)
Affinity DataIC50:  16nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Idenix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50023509(CHEMBL3326540)
Affinity DataIC50:  17nMAssay Description:Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191173(1-(2-methylpropyl)-4'-(pyridin-4-yl)-8'-oxa-5',6'-...)
Affinity DataIC50:  21nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191181(12'-fluoro-4'-(4-fluorophenyl)-1-propyl-8'-oxa-5',...)
Affinity DataIC50:  26nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191208(12'-bromo-4'-(4-fluorophenyl)-1-propyl-8'-oxa-5',6...)
Affinity DataIC50:  29nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191194(12'-bromo-4'-(4-fluorophenyl)-1-methyl-8'-oxa-5',6...)
Affinity DataIC50:  30nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191191(12'-chloro-4'-(4-fluorophenyl)-1-propyl-8'-oxa-5',...)
Affinity DataIC50:  32nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191196(1-ethyl-4'-(pyridin-4-yl)-8'-oxa-5',6'-diazaspiro[...)
Affinity DataIC50:  42nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Idenix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50023507(CHEMBL3326538)
Affinity DataIC50:  45nMAssay Description:Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191209(4'-(4-fluorophenyl)-10'-methoxy-1-methyl-8'-oxa-5'...)
Affinity DataIC50:  46nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191188(1-methyl-4'-phenyl-8'-oxa-5',6'-diazaspiro[piperid...)
Affinity DataIC50:  50nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191178(12'-bromo-1-methyl-4'-phenyl-8'-oxa-5',6'-diazaspi...)
Affinity DataIC50:  92nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191212(1-methyl-4'-(pyridin-4-yl)-8'-oxa-5',6'-diazaspiro...)
Affinity DataIC50:  95nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191187(12'-bromo-4'-(4-chlorophenyl)-1-methyl-8'-oxa-5',6...)
Affinity DataIC50:  100nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Idenix An Msd

Curated by ChEMBL
LigandPNGBDBM50459813(CHEMBL4205384)
Affinity DataIC50:  114nMAssay Description:Inhibition of full-length wild-type HIV1 reverse transcriptase expressed in Escherichia coli BL21(DE3) pre-incubated for 30 mins before addition of t...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191180(4'-(4-fluorophenyl)-12'-methyl-1-propyl-8'-oxa-5',...)
Affinity DataIC50:  115nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191175(4'-(4-chlorophenyl)-1-(propan-2-yl)-8'-oxa-5',6'-d...)
Affinity DataIC50:  133nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191211(12'-bromo-4'-[4-(difluoromethoxy)phenyl]-1-methyl-...)
Affinity DataIC50:  175nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191172(12'-bromo-4'-(4-methoxyphenyl)-1-propyl-8'-oxa-5',...)
Affinity DataIC50:  179nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191185(12'-bromo-4'-phenyl-1-(propan-2-yl)-8'-oxa-5',6'-d...)
Affinity DataIC50:  188nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM426318(US10513534, Compound 406)
Affinity DataIC50: <250nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM426315(US10513534, Compound 403)
Affinity DataIC50: <250nMMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM426317(US10513534, Compound 405)
Affinity DataIC50: <250nMMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM426312(US10513534, Compound 401)
Affinity DataIC50: <250nMAssay Description:Test compounds in the form of nucleoside triphosphates were examined for inhibitory activity against purified HCV polymerase in a standard assay. Bac...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
Idenix Pharmaceuticals

US Patent
LigandPNGBDBM426319(US10513534, Compound 407)
Affinity DataIC50: <250nMMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReverse transcriptase(Human immunodeficiency virus 1)
Idenix An Msd

Curated by ChEMBL
LigandPNGBDBM50459816(CHEMBL518606)
Affinity DataIC50:  263nMAssay Description:Inhibition of full-length wild-type HIV1 reverse transcriptase expressed in Escherichia coli BL21(DE3) pre-incubated for 30 mins before addition of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Idenix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50023581(CHEMBL3326537)
Affinity DataIC50:  278nMAssay Description:Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191204(4'-(4-chlorophenyl)-1-methyl-8'-oxa-5',6'-diazaspi...)
Affinity DataIC50:  280nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Idenix An Msd

Curated by ChEMBL
LigandPNGBDBM50459815(CHEMBL4216055)
Affinity DataIC50:  324nMAssay Description:Inhibition of full-length wild-type HIV1 reverse transcriptase expressed in Escherichia coli BL21(DE3) pre-incubated for 30 mins before addition of t...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191206(1-benzyl-4'-(4-chlorophenyl)-8'-oxa-5',6'-diazaspi...)
Affinity DataIC50:  350nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191210(4'-(4-bromophenyl)-1-methyl-8'-oxa-5',6'-diazaspir...)
Affinity DataIC50:  426nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191199(12'-bromo-4'-[2-(difluoromethoxy)phenyl]-1-methyl-...)
Affinity DataIC50:  427nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Idenix An Msd

Curated by ChEMBL
LigandPNGBDBM50459812(CHEMBL4214561)
Affinity DataIC50:  444nMAssay Description:Inhibition of full-length wild-type HIV1 reverse transcriptase expressed in Escherichia coli BL21(DE3) pre-incubated for 30 mins before addition of t...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191176(4'-(2-chlorophenyl)-1-propyl-8'-oxa-5',6'-diazaspi...)
Affinity DataIC50:  500nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Idenix An Msd

Curated by ChEMBL
LigandPNGBDBM50459817(CHEMBL4211088)
Affinity DataIC50:  523nMAssay Description:Inhibition of full-length wild-type HIV1 reverse transcriptase expressed in Escherichia coli BL21(DE3) pre-incubated for 30 mins before addition of t...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191192(12'-bromo-4'-(3,4-dichlorophenyl)-1-methyl-8'-oxa-...)
Affinity DataIC50:  542nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191186(4'-(2-chlorophenyl)-1-methyl-8'-oxa-5',6'-diazaspi...)
Affinity DataIC50:  753nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191195(12'-bromo-4'-(4-bromophenyl)-1-propyl-8'-oxa-5',6'...)
Affinity DataIC50:  791nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191207(12'-bromo-4'-(2-chlorophenyl)-1-methyl-8'-oxa-5',6...)
Affinity DataIC50:  856nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Idenix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50023576(CHEMBL3326827)
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Idenix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50023577(CHEMBL3326828)
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of full length Hepatitis C virus genotype 1b Con1 NS3/4A by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Hopital Saint-Louis

Curated by ChEMBL
LigandPNGBDBM50191203(4'-(4-bromophenyl)-10'-methoxy-1-methyl-8'-oxa-5',...)
Affinity DataIC50:  1.28E+3nMAssay Description:Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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