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Found 4312 with Last Name = 'ravula' and Initial = 's'
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316938(1-(4-fluorobenzyl)-2-(1-methylpiperidin-3-yl)-1H-b...)
Affinity DataKi:  0.5nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50361005(CHEMBL1935442)
Affinity DataKi:  0.800nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316936(2-(1-methylpiperidin-3-yl)-1-(2-phenoxyethyl)-1H-b...)
Affinity DataKi:  0.800nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316940((R)-1-(4-fluorobenzyl)-2-(1-methylpiperidin-3-yl)-...)
Affinity DataKi:  0.900nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50361001(CHEMBL1935438)
Affinity DataKi:  1nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50361004(CHEMBL1935441)
Affinity DataKi:  1nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50360999(CHEMBL1935436)
Affinity DataKi:  1nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50361000(CHEMBL1935437)
Affinity DataKi:  1.20nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50361007(CHEMBL1935444)
Affinity DataKi:  1.30nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50361008(CHEMBL1935446)
Affinity DataKi:  1.30nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50361009(CHEMBL1935447)
Affinity DataKi:  1.40nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50361007(CHEMBL1935444)
Affinity DataKi:  1.5nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50361007(CHEMBL1935444)
Affinity DataKi:  1.5nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50361006(CHEMBL1935443)
Affinity DataKi:  1.90nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50361006(CHEMBL1935443)
Affinity DataKi:  1.90nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50297861(1-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)-N-...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50297861(1-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)-N-...)
Affinity DataKi:  3.90nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50361008(CHEMBL1935446)
Affinity DataKi:  4nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50361008(CHEMBL1935446)
Affinity DataKi:  4nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316921((S)-1-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)...)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50360996(CHEMBL1935433)
Affinity DataKi:  4.90nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50384714(CHEMBL2037200)
Affinity DataKi:  5nMAssay Description:Reversible inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50360995(CHEMBL1935432)
Affinity DataKi:  6.30nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50297850(1-(4-fluorobenzyl)-2-(4-(4-methyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  6.90nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50297850(1-(4-fluorobenzyl)-2-(4-(4-methyl-1H-pyrazol-1-yl)...)
Affinity DataKi:  6.90nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50360998(CHEMBL1935435)
Affinity DataKi:  8.10nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50360998(CHEMBL1935435)
Affinity DataKi:  8.10nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316922((R)-1-(1-(4-methoxybenzyl)-1H-benzo[d]imidazol-2-y...)
Affinity DataKi:  8.40nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50360994(CHEMBL1935431)
Affinity DataKi:  8.90nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50360994(CHEMBL1935431)
Affinity DataKi:  8.90nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50361003(CHEMBL1935439)
Affinity DataKi:  11.9nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50361003(CHEMBL1935439)
Affinity DataKi:  11.9nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50360997(CHEMBL1935434)
Affinity DataKi:  16.6nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50361002(CHEMBL1935440)
Affinity DataKi:  24.6nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316936(2-(1-methylpiperidin-3-yl)-1-(2-phenoxyethyl)-1H-b...)
Affinity DataKi:  40nMAssay Description:Inhibition of muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50361009(CHEMBL1935447)
Affinity DataKi:  92nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50361008(CHEMBL1935446)
Affinity DataKi:  230nMAssay Description:Inhibition of muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50361008(CHEMBL1935446)
Affinity DataKi:  340nMAssay Description:Inhibition of muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50361001(CHEMBL1935438)
Affinity DataKi:  430nMAssay Description:Inhibition of muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50361000(CHEMBL1935437)
Affinity DataKi:  480nMAssay Description:Inhibition of muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316932(2-(1-methylpiperidin-3-yl)-1-((tetrahydrofuran-2-y...)
Affinity DataKi:  638nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316930(2-(1-cyclohexylpiperidin-3-yl)-1-(4-fluorobenzyl)-...)
Affinity DataKi:  926nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50361007(CHEMBL1935444)
Affinity DataKi:  930nMAssay Description:Inhibition of muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316924(2-((2-(1-cyclohexylpiperidin-3-yl)-1H-benzo[d]imid...)
Affinity DataKi:  1.18E+3nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316935(1-(2-ethoxyethyl)-2-(1-methylpiperidin-3-yl)-1H-be...)
Affinity DataKi:  1.26E+3nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316931(1-(4-fluorobenzyl)-2-(1-isopropylpiperidin-3-yl)-1...)
Affinity DataKi:  1.37E+3nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316921((S)-1-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)...)
Affinity DataKi:  1.50E+3nMAssay Description:Displacement of [3H]N-methyl scopolamine from human muscarinic M1 receptor expressed in CHO Flp-In cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316928(2-(1-cyclohexylpiperidin-3-yl)-1-(4-methoxybenzyl)...)
Affinity DataKi:  1.84E+3nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50316922((R)-1-(1-(4-methoxybenzyl)-1H-benzo[d]imidazol-2-y...)
Affinity DataKi:  2.50E+3nMAssay Description:Displacement of [3H]N-methyl scopolamine from human muscarinic M1 receptor expressed in CHO Flp-In cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50360994(CHEMBL1935431)
Affinity DataKi:  2.60E+3nMAssay Description:Displacement of [3H]dofetolide from human ErgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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