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Found 627 with Last Name = 'reader' and Initial = 'jc'
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50177232(4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...)
Affinity DataIC50:  0.100nMAssay Description:Inhibitory activity against Farnesyltransferase quantified by modified SPA assay with improved sensitivityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sareum

US Patent
LigandPNGBDBM180866(US9133180, 7)
Affinity DataIC50:  0.480nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure:1) Prepare indicated substrate in fr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50555401(CHEMBL4742233)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50555385(CHEMBL4753307)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM328998(1137478-52-4 | US11787792, Compound Y-158 | US9663...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sareum

US Patent
LigandPNGBDBM180867(US9133180, 8)
Affinity DataIC50:  0.550nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure:1) Prepare indicated substrate in fr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sareum

US Patent
LigandPNGBDBM180869(US9133180, 10)
Affinity DataIC50:  0.670nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure:1) Prepare indicated substrate in fr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sareum

US Patent
LigandPNGBDBM180861(US9133180, 2)
Affinity DataIC50:  0.770nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure:1) Prepare indicated substrate in fr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sareum

US Patent
LigandPNGBDBM180862(US9133180, 3)
Affinity DataIC50:  0.821nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure:1) Prepare indicated substrate in fr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sareum

US Patent
LigandPNGBDBM180864(US9133180, 5)
Affinity DataIC50:  0.890nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure:1) Prepare indicated substrate in fr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50555402(CHEMBL4790962)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sareum

US Patent
LigandPNGBDBM180863(US9133180, 4)
Affinity DataIC50:  0.970nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure:1) Prepare indicated substrate in fr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50555384(CHEMBL4789854)
Affinity DataIC50:  1nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50401628(CHEMBL2203840)
Affinity DataIC50: <1nMAssay Description:Inhibition of CHK1 using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH as substrate after 1 hr by microfluidic assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50401627(CHEMBL2203844)
Affinity DataIC50: <1nMAssay Description:Inhibition of CHK1 using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH as substrate after 1 hr by microfluidic assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50401629(CHEMBL2203839)
Affinity DataIC50: <1nMAssay Description:Inhibition of CHK1 using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH as substrate after 1 hr by microfluidic assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50177232(4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory activity against Ha-Ras processing in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM328993(5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(triflu...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sareum

US Patent
LigandPNGBDBM180865(US9133180, 6)
Affinity DataIC50:  1.37nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure:1) Prepare indicated substrate in fr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sareum

US Patent
LigandPNGBDBM180870(US9133180, 11)
Affinity DataIC50:  1.54nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure:1) Prepare indicated substrate in fr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50555409(CHEMBL4754960)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sareum

US Patent
LigandPNGBDBM180860(US9133180, 1)
Affinity DataIC50:  1.92nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure:1) Prepare indicated substrate in fr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50177232(4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against farnesyltransferase quantified by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  2.10nMAssay Description:Competitive inhibition of human CHK1 using ATP as substrate by DELFIAMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50555405(CHEMBL4784718)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM328996(1137477-07-6 | US11787792, Compound Y-081 | US9663...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM329000(1137478-46-6 | US11787792, Compound Y-153 | US9663...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sareum

US Patent
LigandPNGBDBM474482(2-(2,6-Dichloro-phenyl)-5- (4-methanesulfonyl- phe...)
Affinity DataIC50:  2.30nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate in f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sareum

US Patent
LigandPNGBDBM474482(2-(2,6-Dichloro-phenyl)-5- (4-methanesulfonyl- phe...)
Affinity DataIC50:  2.30nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sareum

US Patent
LigandPNGBDBM474483(2-(2-Chloro-6-fluoro- phenyl)-5-(4- methanesulfony...)
Affinity DataIC50:  2.70nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sareum

US Patent
LigandPNGBDBM474483(2-(2-Chloro-6-fluoro- phenyl)-5-(4- methanesulfony...)
Affinity DataIC50:  2.70nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate in f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sareum

US Patent
LigandPNGBDBM180871(US9133180, 12)
Affinity DataIC50:  2.80nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure:1) Prepare indicated substrate in fr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50555383(CHEMBL4784549)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50401632(CHEMBL2204590)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of CHK1 using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH as substrate after 1 hr by microfluidic assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50401617(CHEMBL2204592 | US9403797, PAPC-A-02)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of CHK1 using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH as substrate after 1 hr by microfluidic assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM328997(1137478-45-5 | US11787792, Compound Y-152 | US9663...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50401615(CHEMBL2203842)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of CHK1 using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH as substrate after 1 hr by microfluidic assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50359810(CHEMBL1928701)
Affinity DataIC50:  3.80nMAssay Description:Competitive inhibition of human CHK1 using ATP as substrate by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50177232(4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...)
Affinity DataIC50:  4.20nMAssay Description:Inhibitory activity against Ha-Ras processing in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50177232(4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...)
Affinity DataIC50:  4.20nMAssay Description:Inhibitory activity against Ha-Ras processing in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50401616(CHEMBL2203841)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of CHK1 using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH as substrate after 1 hr by microfluidic assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50177232(4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...)
Affinity DataIC50:  4.5nMAssay Description:Inhibitory activity against farnesyltransferase quantified by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50177232(4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...)
Affinity DataIC50:  4.5nMAssay Description:Inhibitory activity against farnesyltransferase quantified by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50555404(CHEMBL4797851)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50555392(CHEMBL4760882)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50177232(4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...)
Affinity DataIC50:  5nMAssay Description:Anchorage-independent growth of transformed NIH3T3 cells in soft agarMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50555406(CHEMBL4740741)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50555398(CHEMBL4742116)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50177232(4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...)
Affinity DataIC50:  5.20nMAssay Description:Anchorage-independent growth of transformed NIH3T3 cells in soft agarMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sareum

US Patent
LigandPNGBDBM474463(Example Q-26 in WO2008/139161 | US10882829, Exampl...)
Affinity DataIC50:  5.30nMAssay Description:Kinase assays were performed at Reaction Biology Corp., Malvern, Pa., USA, using the following general procedure: 1) Prepare indicated substrate in f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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