Affinity DataKi: 0.180nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
Affinity DataKi: 0.190nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
Affinity DataKi: 0.360nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
Affinity DataKi: 0.380nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
Affinity DataKi: 1.75nM ΔG°: -49.5kJ/molepH: 7.4 T: 2°CAssay Description:The inhibitors reported in this study bind to CHK1 according to a general mechanism illustrated in Scheme 1 where E, S, and I stand for enzyme, subst...More data for this Ligand-Target Pair
Affinity DataKi: 5.14nM ΔG°: -46.5kJ/molepH: 8.0 T: 2°CAssay Description:Surface plasmon resonance (SPR) biosensor binding studies were conducted using a Biacore 3000 instrument (GE Healtchare).More data for this Ligand-Target Pair
Affinity DataKi: 146nM ΔG°: -38.6kJ/molepH: 7.4 T: 2°CAssay Description:The inhibitors reported in this study bind to CHK1 according to a general mechanism illustrated in Scheme 1 where E, S, and I stand for enzyme, subst...More data for this Ligand-Target Pair
Affinity DataKi: 290nM ΔG°: -36.7kJ/molepH: 8.0 T: 2°CAssay Description:Surface plasmon resonance (SPR) biosensor binding studies were conducted using a Biacore 3000 instrument (GE Healtchare).More data for this Ligand-Target Pair
Affinity DataKi: 301nMAssay Description:Inhibition of human CHK1 expressed in baculovirus/insect cell systemMore data for this Ligand-Target Pair
Affinity DataKi: 1.89E+3nM ΔG°: -32.3kJ/molepH: 7.4 T: 2°CAssay Description:The inhibitors reported in this study bind to CHK1 according to a general mechanism illustrated in Scheme 1 where E, S, and I stand for enzyme, subst...More data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Inhibition of human SGKMore data for this Ligand-Target Pair
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of NEK2More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of ABLMore data for this Ligand-Target Pair
Affinity DataIC50: 1.72E+3nMAssay Description:Inhibition of PIM2More data for this Ligand-Target Pair
Affinity DataIC50: 1.85E+3nMAssay Description:Inhibition of MASKMore data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type 1(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 2.13E+3nMAssay Description:Inhibition of CAMK1More data for this Ligand-Target Pair
Affinity DataIC50: 2.55E+3nMAssay Description:Inhibition of human LCKMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of CDK1 expressed in Sf21 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 6.34E+3nMAssay Description:Inhibition of CK1deltaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.01E+4nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
Affinity DataIC50: 1.44E+4nMAssay Description:Inhibition of PAK4More data for this Ligand-Target Pair
Affinity DataIC50: 2.69E+4nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of INSRMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
Affinity DataEC50: 41nMAssay Description:Activity at human CHK1 in CA46 cells by histone H3 ELISA assayMore data for this Ligand-Target Pair
Affinity DataEC50: 60nMAssay Description:Activity at human CHK1 in CA46 cells by histone H3 ELISA assayMore data for this Ligand-Target Pair
Affinity DataEC50: 165nMAssay Description:Activity at human CHK1 in CA46 cells by histone H3 ELISA assayMore data for this Ligand-Target Pair
Affinity DataEC50: 230nMAssay Description:Activity at human CHK1 in CA46 cells by histone H3 ELISA assayMore data for this Ligand-Target Pair
Affinity DataEC50: 58nMAssay Description:Activity at human CHK1 in CA46 cells by histone H3 ELISA assayMore data for this Ligand-Target Pair
Affinity DataEC50: 500nMAssay Description:Activity at human CHK1 in CA46 cells by histone H3 ELISA assayMore data for this Ligand-Target Pair
Affinity DataEC50: 70nMAssay Description:Activity at human CHK1 in CA46 cells by histone H3 ELISA assayMore data for this Ligand-Target Pair
Affinity DataEC50: 550nMAssay Description:Activity at human CHK1 in CA46 cells by histone H3 ELISA assayMore data for this Ligand-Target Pair
Affinity DataEC50: 150nMAssay Description:Activity at human CHK1 in CA46 cells by histone H3 ELISA assayMore data for this Ligand-Target Pair