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Found 388 with Last Name = 'reinhart' and Initial = 'p'
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329517((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(2-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50310150((S)-2-amino-4-(2,6-diethylpyridin-4-yl)-4-(3-(2-fl...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329565((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(3,...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329547((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(4-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329554((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(4-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50310150((S)-2-amino-4-(2,6-diethylpyridin-4-yl)-4-(3-(2-fl...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329546((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(3-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50303727((4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329556((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(6-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329558((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-flu...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329571((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-flu...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329568((R)-2-amino-4-(4-(difluoromethoxy)-3-methylphenyl)...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329576((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-flu...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329573((S)-2-amino-4-(3-(cyclopropylethynyl)phenyl)-4-(4-...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329553((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(4-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329555((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-((R...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314607(2-amino-4-(3'-methoxybiphenyl-3-yl)-1-methyl-4-(py...)
Affinity DataIC50:  20nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305468(CHEMBL590829 | N-(3-(2-amino-4-cyclohexyl-1-methyl...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50303717(2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-4-(4-me...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329569((R)-2-amino-4-(3-(cyclopropylethynyl)-4-fluorophen...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314606((5S)-2-amino-5-(2',5'-difluorobiphenyl-3-yl)-3-met...)
Affinity DataIC50:  20nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329550((R)-2-amino-4-(3-(cyclopropylethynyl)phenyl)-4-(4-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329549((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329535((R,E)-2-amino-4-(3-(2-cyclopropyl-1-fluorovinyl)ph...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329538((R,E)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329537((R,E)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329574((R)-2-amino-4-(4-(difluoromethoxy)-3-methylphenyl)...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329561((R)-2-amino-4-(3-(cyclopropylmethoxy)phenyl)-4-(4-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329552((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(3-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329570((R)-2-amino-4-(3-(cyclopropylethynyl)-4-fluorophen...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329543((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329575((R)-2-amino-4-(4-(difluoromethoxy)-3-methylphenyl)...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329567((R)-2-amino-4-(3-(4,4-difluorobut-3-enyloxy)phenyl...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329566((R)-2-amino-4-(3-(4,4-difluorobut-3-enyloxy)-4-flu...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329533((R,E)-2-amino-4-(3-(4,4-difluorobut-1-enyl)phenyl)...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50310158(CHEMBL598259 | rac-2-amino-4-(2-ethylpyridin-4-yl)...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329519((R)-2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-4-(...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329520((R)-2-amino-4-(4-(2-fluoroethoxy)phenyl)-4-(3-(2-f...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329545((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314603(2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-methy...)
Affinity DataIC50:  30nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329525((R)-2-amino-4-(3-butylphenyl)-4-(4-(difluoromethox...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314607(2-amino-4-(3'-methoxybiphenyl-3-yl)-1-methyl-4-(py...)
Affinity DataIC50:  30nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329563((R)-2-amino-4-(3-(2,2-difluoroethoxy)phenyl)-4-(4-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305469(CHEMBL590830 | N-(3-(2-amino-4-cyclohexyl-1-methyl...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50310162((5S)-2-amino-5-(2,6-diethylpyridin-4-yl)-3-methyl-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314994(2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pyrimidin-...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50310152(CHEMBL597277 | rac-2-amino-4-(2,6-diethylpyridin-4...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50303719(2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305472(CHEMBL589614 | N-(3-(2-amino-4-cyclohexyl-1-methyl...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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