Affinity DataKi: 14nMAssay Description:Binding affinity to human alpha7 nAChRMore data for this Ligand-Target Pair
TargetNatural resistance-associated macrophage protein 2(Homo sapiens (Human))
University Of Bern
Curated by ChEMBL
University Of Bern
Curated by ChEMBL
Affinity DataKi: 1.40E+3nMAssay Description:Competitive inhibition of human DMT1 expressed in HEK293T cells by measuring inhibition of radiolabeled-55Fe2+ uptake by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.60E+3nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 6.60E+3nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 1.20E+4nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 5.20E+4nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0640nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
University Of Berne
Curated by ChEMBL
University Of Berne
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of Aurora B kinase in human HeLa Kyoto cells assessed as effect on distribution of phspho-histone H3 ser10 level incubated for 20 hrsMore data for this Ligand-Target Pair
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
University Of Berne
Curated by ChEMBL
University Of Berne
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
Affinity DataIC50: 6.20nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
Affinity DataIC50: 6.20nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
Affinity DataIC50: 6.70nMAssay Description:Inhibition of Aurora A kinase autophosphorylation at Thr288 in human HeLa Kyoto cells incubated for 20 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: >10nMAssay Description:Inhibition of Aurora B kinase in human HeLa Kyoto cells assessed as effect on distribution of phspho-histone H3 ser10 level incubated for 20 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of Aurora A kinase autophosphorylation at Thr288 in human HeLa Kyoto cells incubated for 20 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 6(Homo sapiens (Human))
University Of Bern
Curated by ChEMBL
University Of Bern
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human TRPV6 expressed in HEK293 cells assessed as reduction in Cd2+ influx by calcium-5 fluorescence dye-based FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 6(Homo sapiens (Human))
University Of Bern
Curated by ChEMBL
University Of Bern
Curated by ChEMBL
Affinity DataIC50: 64nMAssay Description:Inhibition of human TRPV6 expressed in HEK293 cells assessed as reduction in Cd2+ influx by calcium-5 fluorescence dye-based FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 6(Homo sapiens (Human))
University Of Bern
Curated by ChEMBL
University Of Bern
Curated by ChEMBL
Affinity DataIC50: 82nMAssay Description:Inhibition of human TRPV6 expressed in HEK293 cells assessed as reduction in Cd2+ influx by calcium-5 fluorescence dye-based FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 6(Homo sapiens (Human))
University Of Bern
Curated by ChEMBL
University Of Bern
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of human TRPV6 expressed in HEK293 cells assessed as reduction in Cd2+ influx by calcium-5 fluorescence dye-based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
TargetNatural resistance-associated macrophage protein 2(Homo sapiens (Human))
University Of Bern
Curated by ChEMBL
University Of Bern
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of human DMT1 expressed in Xenopus oocytes assessed as inhibition of channel currents at -50 mV holding potential by two-electrode voltage...More data for this Ligand-Target Pair
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
University Of Berne
Curated by ChEMBL
University Of Berne
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 6(Homo sapiens (Human))
University Of Bern
Curated by ChEMBL
University Of Bern
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of human TRPV6 expressed in HEK293 cells assessed as reduction in Cd2+ influx by calcium-5 fluorescence dye-based FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 6(Homo sapiens (Human))
University Of Bern
Curated by ChEMBL
University Of Bern
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of human TRPV6 expressed in HEK293 cells assessed as reduction in Cd2+ influx by calcium-5 fluorescence dye-based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
Affinity DataIC50: 249nMAssay Description:Inhibition of Pseudomonas aeruginosa LecB by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of Aurora A kinase autophosphorylation at Thr288 in human HeLa Kyoto cells incubated for 20 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of human EAAC1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 6(Homo sapiens (Human))
University Of Bern
Curated by ChEMBL
University Of Bern
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Inhibition of human TRPV6 expressed in HEK293 cells assessed as reduction of Cd2+ influx preincubated for 5 mins followed by CdCl2 addition by calciu...More data for this Ligand-Target Pair
TargetNatural resistance-associated macrophage protein 2(Homo sapiens (Human))
University Of Bern
Curated by ChEMBL
University Of Bern
Curated by ChEMBL
Affinity DataIC50: 350nMAssay Description:Inhibition of human DMT1 expressed in HEK293T cells assessed as inhibition of radiolabeled 55Fe2+ uptake preincubated with compound for 5 mins follow...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 6(Homo sapiens (Human))
University Of Bern
Curated by ChEMBL
University Of Bern
Curated by ChEMBL
Affinity DataIC50: 370nMAssay Description:Inhibition of human TRPV6 expressed in HEK293 cells assessed as reduction in Cd2+ influx by calcium-5 fluorescence dye-based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
Affinity DataIC50: 380nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
Affinity DataIC50: 390nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 4(Homo sapiens)
University Of Berne
Curated by ChEMBL
University Of Berne
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of Flag-tagged TRPM4 (unknown origin) expressed in HEK293 cells assessed as reduction in intracellular Na+ influx after 45 mins by ANG2 dy...More data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 6(Homo sapiens (Human))
University Of Bern
Curated by ChEMBL
University Of Bern
Curated by ChEMBL
Affinity DataIC50: 430nMAssay Description:Inhibition of human TRPV6 expressed in HEK293 cells assessed as reduction in Cd2+ influx by calcium-5 fluorescence dye-based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 480nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of Pseudomonas aeruginosa LecB by fluorescence polarization assayMore data for this Ligand-Target Pair