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Found 5304 with Last Name = 'roberts' and Initial = 'e'
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50130563((3R)-7-Hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphe...)
Affinity DataKi:  0.0200nMAssay Description:Antagonist activity at kappa opioid receptor in guinea pig caudate assessed as inhibition of U69593-stimulated [35S]-GTP[gammaS] bindingMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281663(10-cyclopropylmethyl-1-ethyl-4-hydroxy-13-methyl-(...)
Affinity DataKi:  0.210nMAssay Description:Tested in vitro for binding affinity against Opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R & D Montr£Al

Curated by ChEMBL
LigandPNGBDBM50302760(CHEMBL568818 | N,N-diethyl-4-((1-(2-(furan-3-yl)et...)
Affinity DataKi:  0.220nMAssay Description:Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R & D Montr£Al

Curated by ChEMBL
LigandPNGBDBM50302755(CHEMBL569316 | N,N-diethyl-4-((3-hydroxyphenyl)(1-...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R & D Montr£Al

Curated by ChEMBL
LigandPNGBDBM50302759(CHEMBL584941 | N,N-diethyl-4-((3-hydroxyphenyl)(1-...)
Affinity DataKi:  0.270nMAssay Description:Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R & D Montr£Al

Curated by ChEMBL
LigandPNGBDBM50302756(4-((1-(2-(1H-imidazol-2-yl)ethyl)piperidin-4-yl)(3...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R & D Montr£Al

Curated by ChEMBL
LigandPNGBDBM50302758(CHEMBL570000 | N,N-diethyl-4-((1-(2-(furan-2-yl)et...)
Affinity DataKi:  0.420nMAssay Description:Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R & D Montr£Al

Curated by ChEMBL
LigandPNGBDBM50302765(CHEMBL569755 | N,N-diethyl-4-((3-hydroxyphenyl)(1-...)
Affinity DataKi:  0.420nMAssay Description:Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R & D Montr£Al

Curated by ChEMBL
LigandPNGBDBM50302763(CHEMBL569728 | N,N-diethyl-4-((3-hydroxyphenyl)(1-...)
Affinity DataKi:  0.640nMAssay Description:Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R & D Montr£Al

Curated by ChEMBL
LigandPNGBDBM50302757(CHEMBL568803 | N,N-diethyl-4-((3-hydroxyphenyl)(1-...)
Affinity DataKi:  0.650nMAssay Description:Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R & D Montr£Al

Curated by ChEMBL
LigandPNGBDBM50302761(CHEMBL569006 | N,N-diethyl-4-((1-(3-fluorophenethy...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R & D Montr£Al

Curated by ChEMBL
LigandPNGBDBM50302762(CHEMBL576267 | N,N-diethyl-4-((1-(2-fluorophenethy...)
Affinity DataKi:  0.760nMAssay Description:Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R & D Montr£Al

Curated by ChEMBL
LigandPNGBDBM50302766(4-((1-(2-cyclopropylethyl)piperidin-4-yl)(3-hydrox...)
Affinity DataKi:  0.970nMAssay Description:Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R & D Montr£Al

Curated by ChEMBL
LigandPNGBDBM50302769(CHEMBL571324 | N,N-diethyl-4-((3-hydroxyphenyl)(1-...)
Affinity DataKi:  0.990nMAssay Description:Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R & D Montr£Al

Curated by ChEMBL
LigandPNGBDBM50302777(CHEMBL569529 | N,N-diethyl-4-((3-hydroxyphenyl)(1-...)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281663(10-cyclopropylmethyl-1-ethyl-4-hydroxy-13-methyl-(...)
Affinity DataKi:  1nMAssay Description:Tested in vitro for binding affinity against mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R & D Montr£Al

Curated by ChEMBL
LigandPNGBDBM50302768(4-((1-(but-3-enyl)piperidin-4-yl)(3-hydroxyphenyl)...)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50350976(CHEMBL1818341)
Affinity DataKi:  1.20nMAssay Description:Antagonist activity at human cloned kappa opioid receptor expressed in CHO cells assessed as inhibition of U69593-stimulated [35S]-GTP[gammaS] bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R & D Montr£Al

Curated by ChEMBL
LigandPNGBDBM50039029((+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpipe...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R & D Montr£Al

Curated by ChEMBL
LigandPNGBDBM50302764(CHEMBL568865 | N,N-diethyl-4-((3-hydroxyphenyl)(1-...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50531908(Btrx-335140 | CYM-53093 | US10676469, Compound 142...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]diprenorphine from human KORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R & D Montr£Al

Curated by ChEMBL
LigandPNGBDBM50302776(4-((1-(2-(1H-imidazol-4-yl)ethyl)piperidin-4-yl)(3...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50012152(CHEMBL3264441)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]diprenorphine from kappa opioid receptor (unknown origin) expressed in CHO cells membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R & D Montr£Al

Curated by ChEMBL
LigandPNGBDBM50302778(CHEMBL570448 | N,N-diethyl-4-((3-hydroxyphenyl)(1-...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50130563((3R)-7-Hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphe...)
Affinity DataKi:  2.20nMAssay Description:Antagonist activity at mu opioid receptor in guinea pig caudate assessed as inhibition of DAMGO-stimulated [35S]-GTP[gammaS] bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R & D Montr£Al

Curated by ChEMBL
LigandPNGBDBM50302767(4-((1-(2-cyclohexylethyl)piperidin-4-yl)(3-hydroxy...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50205093(CHEMBL428017 | LRHYLNLLTRQRY-NH2)
Affinity DataKi:  5nMAssay Description:Binding affinity to NPYY2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50012151(CHEMBL3264440)
Affinity DataKi:  6.60nMAssay Description:Displacement of [3H]diprenorphine from mu opioid receptor (unknown origin) expressed in CHO cells membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50445617(CHEMBL3104112)
Affinity DataKi:  9.10nMAssay Description:Binding affinity to NPYY2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50445619(CHEMBL3104224)
Affinity DataKi:  9.90nMAssay Description:Binding affinity to NPYY2 receptor (unknown origin) preincubated for 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50350976(CHEMBL1818341)
Affinity DataKi:  10nMAssay Description:Antagonist activity at human cloned mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-stimulated [35S]-GTP[gammaS] bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R & D Montr£Al

Curated by ChEMBL
LigandPNGBDBM50302773(CHEMBL570645 | N,N-diethyl-4-((3-methoxyphenyl)(1-...)
Affinity DataKi:  11nMAssay Description:Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R & D Montr£Al

Curated by ChEMBL
LigandPNGBDBM50302771(CHEMBL569704 | N,N-diethyl-4-((1-(2-(furan-3-yl)et...)
Affinity DataKi:  14nMAssay Description:Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R & D Montr£Al

Curated by ChEMBL
LigandPNGBDBM50302774(CHEMBL569945 | N,N-diethyl-4-((3-methoxyphenyl)(1-...)
Affinity DataKi:  18nMAssay Description:Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R & D Montr£Al

Curated by ChEMBL
LigandPNGBDBM50302770(4-((1-(2-(1H-imidazol-2-yl)ethyl)piperidin-4-yl)(3...)
Affinity DataKi:  23nMAssay Description:Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50012151(CHEMBL3264440)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]diprenorphine from kappa opioid receptor (unknown origin) expressed in CHO cells membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50445618(CHEMBL3104111)
Affinity DataKi:  26nMAssay Description:Binding affinity to NPYY2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50012152(CHEMBL3264441)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]diprenorphine from mu opioid receptor (unknown origin) expressed in CHO cells membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50012153(zyklophin)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]diprenorphine from kappa opioid receptor (unknown origin) expressed in CHO cells membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-B receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289794(CHEMBL292119 | [2-(1H-Indol-3-yl)-1-isobutylcarbam...)
Affinity DataKi:  37nMAssay Description:Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R & D Montr£Al

Curated by ChEMBL
LigandPNGBDBM50302775(CHEMBL569084 | N,N-diethyl-4-((3-methoxyphenyl)(1-...)
Affinity DataKi:  50nMAssay Description:Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R & D Montr£Al

Curated by ChEMBL
LigandPNGBDBM50302772(CHEMBL570446 | N,N-diethyl-4-((1-(2-(furan-2-yl)et...)
Affinity DataKi:  50nMAssay Description:Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50302763(CHEMBL569728 | N,N-diethyl-4-((3-hydroxyphenyl)(1-...)
Affinity DataKi:  62nMAssay Description:Displacement of [125I]FK33824 from human cloned mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50302769(CHEMBL571324 | N,N-diethyl-4-((3-hydroxyphenyl)(1-...)
Affinity DataKi:  87nMAssay Description:Displacement of [125I]FK33824 from human cloned mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50302765(CHEMBL569755 | N,N-diethyl-4-((3-hydroxyphenyl)(1-...)
Affinity DataKi:  88nMAssay Description:Displacement of [125I]FK33824 from human cloned mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50302768(4-((1-(but-3-enyl)piperidin-4-yl)(3-hydroxyphenyl)...)
Affinity DataKi:  98nMAssay Description:Displacement of [125I]D-pro10-dynorphin from human cloned kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50302758(CHEMBL570000 | N,N-diethyl-4-((1-(2-(furan-2-yl)et...)
Affinity DataKi:  115nMAssay Description:Displacement of [125I]FK33824 from human cloned mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50302760(CHEMBL568818 | N,N-diethyl-4-((1-(2-(furan-3-yl)et...)
Affinity DataKi:  121nMAssay Description:Displacement of [125I]D-pro10-dynorphin from human cloned kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50302766(4-((1-(2-cyclopropylethyl)piperidin-4-yl)(3-hydrox...)
Affinity DataKi:  126nMAssay Description:Displacement of [125I]FK33824 from human cloned mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50302759(CHEMBL584941 | N,N-diethyl-4-((3-hydroxyphenyl)(1-...)
Affinity DataKi:  127nMAssay Description:Displacement of [125I]FK33824 from human cloned mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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