Affinity DataIC50: 0.0400nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0700nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
Affinity DataIC50: 0.0700nMAssay Description:Displacement of [125I]nonpeptide ligand (compound 7) from purified human recombinant alphaV-beta3More data for this Ligand-Target Pair
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0800nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
Affinity DataIC50: 0.0800nMAssay Description:Displacement of [125I]nonpeptide ligand (compound 7) from purified human recombinant alphaV-beta3More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Displacement of [125I]echistatin from human recombinant alpha-v beta-3 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of alpha v beta 3 receptor bindingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.110nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
Affinity DataIC50: 0.110nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
Affinity DataIC50: 0.130nMAssay Description:Displacement of [125I]-labeled nonpeptide from purified recombinant human alphaV-beta3 integrinMore data for this Ligand-Target Pair
Affinity DataIC50: 0.160nMAssay Description:Inhibition of 2(S)-(4-125-iodo-benzenesulfonylamino)-3-4-[2-(5,6,7,8-tetrahydro- [1,8]naphthyridin-2-yl)-ethyl]-benzoylamino-propionic acid binding t...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 0.210nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
Affinity DataIC50: 0.220nMAssay Description:Displacement of [125I]-labeled nonpeptide from purified recombinant human alphaV-beta3 integrinMore data for this Ligand-Target Pair
Affinity DataIC50: 0.240nMAssay Description:Inhibition of 2(S)-(4-125-iodo-benzenesulfonylamino)-3-4-[2-(5,6,7,8-tetrahydro- [1,8]naphthyridin-2-yl)-ethyl]-benzoylamino-propionic acid binding t...More data for this Ligand-Target Pair
Affinity DataIC50: 0.240nMAssay Description:Inhibition of 2(S)-(4-125-iodo-benzenesulfonylamino)-3-4-[2-(5,6,7,8-tetrahydro- [1,8]naphthyridin-2-yl)-ethyl]-benzoylamino-propionic acid binding t...More data for this Ligand-Target Pair
Affinity DataIC50: 0.25nMAssay Description:Displacement of [125I]-labeled nonpeptide from purified recombinant human alphaV-beta3 integrinMore data for this Ligand-Target Pair
Affinity DataIC50: 0.25nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.290nMAssay Description:Inhibition of binding to human integrin receptor alpha V beta3More data for this Ligand-Target Pair
Affinity DataIC50: 0.290nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Displacement of [125I]L-775,219 from human recombinant alphaV-beta3 integrinMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Displacement of [125I]L-775,219 from human recombinant alphaV-beta3 integrinMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Displacement of [125I]echistatin from human recombinant alpha-v beta-3 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of alpha v beta 3 receptor bindingMore data for this Ligand-Target Pair
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
TargetCathepsin K(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 0.310nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
Affinity DataIC50: 0.320nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
Affinity DataIC50: 0.350nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
Affinity DataIC50: 0.350nMAssay Description:Inhibition of rate of ADP-stimulated gel-filtered human platelet aggregation mediated by integrin alphaIIb beta-3 in PLAGGIN assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.350nMAssay Description:Inhibition of binding to human integrin receptor alpha V beta3More data for this Ligand-Target Pair
Affinity DataIC50: 0.350nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.390nMAssay Description:Displacement of [125I]-labeled nonpeptide from purified recombinant human alphaV-beta3 integrinMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Displacement of [125I]L-775,219 from human recombinant alphaV-beta3 integrinMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Displacement of [125I]echistatin from human recombinant alpha-v beta-3 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of alpha v beta 3 receptor bindingMore data for this Ligand-Target Pair