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Found 41 with Last Name = 'schaeffer' and Initial = 'e'
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293568(CHEMBL563761 | Cis-N-(3-Chlorobenzyl)-N-(-4-aminoc...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity to GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293558(1-Methyl-1H-imidazole-4-carboxylic acid(3-ethyl-3-...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293557((R)-N[3-phenyl-3-(4'-(4-toluoyl)phenoxy)-propyl]sa...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293560(1-Methyl-1H-imidazole-4-carboxylic acid(3-methyl-3...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293559(1-Methyl-1H-imidazole-4-carboxylic acid(3-cyclopro...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293561(1-Methyl-1H-imidazole-4-carboxylic acid(3-cyclopen...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity to GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293562(1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-b...)
Affinity DataKi:  4.60nMAssay Description:Binding affinity to GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293563(1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-b...)
Affinity DataKi:  11nMAssay Description:Binding affinity to GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293564(1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-4...)
Affinity DataKi:  12nMAssay Description:Binding affinity to GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293565(1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicy...)
Affinity DataKi:  15nMAssay Description:Binding affinity to GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293566(1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicy...)
Affinity DataKi:  95nMAssay Description:Binding affinity to GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293567(1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicy...)
Affinity DataKi:  109nMAssay Description:Binding affinity to GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Torpedo californica)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50143282((-)-cytisine | (1R,5S)-1,2,3,4,5,6-Hexahydro-1,5-m...)
Affinity DataKi:  250nMAssay Description:Inhibition of [125I]alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha1 beta gamma delta of electroplaxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166908(5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca...)
Affinity DataKi:  322nMAssay Description:Inhibition of [125I]alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha-7 subunit in rat GH4C1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Torpedo californica)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166909(10-Aza-tricyclo[6.3.1.0*2,7*]dodeca-2(7),3,5-trien...)
Affinity DataKi:  370nMAssay Description:Inhibition of [125I]alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha1 beta gamma delta of electroplaxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Torpedo californica)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166907(4-nitro-10-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-...)
Affinity DataKi:  690nMAssay Description:Inhibition of [125I]alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha1 beta gamma delta of electroplaxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Torpedo californica)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166908(5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca...)
Affinity DataKi:  3.54E+3nMAssay Description:Inhibition of [125I]alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha1 beta gamma delta of electroplaxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50143282((-)-cytisine | (1R,5S)-1,2,3,4,5,6-Hexahydro-1,5-m...)
Affinity DataKi:  4.20E+3nMAssay Description:Inhibition of [125I]alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha-7 subunit in rat GH4C1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166909(10-Aza-tricyclo[6.3.1.0*2,7*]dodeca-2(7),3,5-trien...)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of [125I]alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha-7 subunit in rat GH4C1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Torpedo californica)
Pfizer

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  6.27E+3nMAssay Description:Inhibition of [125I]alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha1 beta gamma delta of electroplaxMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  6.29E+3nMAssay Description:Inhibition of [125I]alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha-7 subunit in rat GH4C1 cellsMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166907(4-nitro-10-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-...)
Affinity DataKi:  7.34E+3nMAssay Description:Inhibition of [125I]alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha-7 subunit in rat GH4C1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203572((1-(4-(6-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl...)
Affinity DataIC50:  27nMAssay Description:Binding affinity to GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293561(1-Methyl-1H-imidazole-4-carboxylic acid(3-cyclopen...)
Affinity DataIC50:  460nMAssay Description:Inhibition human ERG expressed in HEK293 cells assessed as blockade of membrane current by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293559(1-Methyl-1H-imidazole-4-carboxylic acid(3-cyclopro...)
Affinity DataIC50:  530nMAssay Description:Inhibition human ERG expressed in HEK293 cells assessed as blockade of membrane current by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293568(CHEMBL563761 | Cis-N-(3-Chlorobenzyl)-N-(-4-aminoc...)
Affinity DataIC50:  1.15E+3nMAssay Description:Displacement of [3H]glycine from GlyT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293558(1-Methyl-1H-imidazole-4-carboxylic acid(3-ethyl-3-...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition human ERG expressed in HEK293 cells assessed as blockade of membrane current by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293560(1-Methyl-1H-imidazole-4-carboxylic acid(3-methyl-3...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition human ERG expressed in HEK293 cells assessed as blockade of membrane current by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293564(1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-4...)
Affinity DataIC50:  8.50E+3nMAssay Description:Inhibition human ERG expressed in HEK293 cells assessed as blockade of membrane current by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293559(1-Methyl-1H-imidazole-4-carboxylic acid(3-cyclopro...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]glycine from GlyT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293560(1-Methyl-1H-imidazole-4-carboxylic acid(3-methyl-3...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]glycine from GlyT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293567(1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]glycine from GlyT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293561(1-Methyl-1H-imidazole-4-carboxylic acid(3-cyclopen...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]glycine from GlyT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293563(1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-b...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]glycine from GlyT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293562(1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-b...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]glycine from GlyT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293558(1-Methyl-1H-imidazole-4-carboxylic acid(3-ethyl-3-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]glycine from GlyT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293557((R)-N[3-phenyl-3-(4'-(4-toluoyl)phenoxy)-propyl]sa...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]glycine from GlyT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293564(1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-4...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]glycine from GlyT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293565(1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]glycine from GlyT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293567(1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicy...)
Affinity DataIC50:  1.46E+4nMAssay Description:Inhibition human ERG expressed in HEK293 cells assessed as blockade of membrane current by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50293568(CHEMBL563761 | Cis-N-(3-Chlorobenzyl)-N-(-4-aminoc...)
Affinity DataIC50:  6.56E+4nMAssay Description:Inhibition human ERG expressed in HEK293 cells assessed as blockade of membrane current by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed