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Found 653 with Last Name = 'schaeffer' and Initial = 'mt'
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50200841(CHEMBL220360 | MK-0364 | MK-0634 | N-((2S,3S)-4-(4...)
Affinity DataIC50:  0.300nMAssay Description:Inverse agonist activity at cannabinoid CB1 receptor (unknown origin)More data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50259222(2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)...)
Affinity DataIC50:  0.630nMAssay Description:Inverse agonist activity at human cannabinoid CB1R expressed in CHO cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50204183(5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)-2-(3,5-d...)
Affinity DataIC50:  0.910nMAssay Description:Binding affinity at CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50259391(4-(5-tert-butyl-9-(4-chlorophenyl)-3-oxo-2,3-dihyd...)
Affinity DataIC50:  1nMAssay Description:Inverse agonist activity at human cannabinoid CB1R expressed in CHO cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50259337(3-((7-(2-chlorophenyl)-6-(4-chlorophenyl)-2-isopro...)
Affinity DataIC50:  1.10nMAssay Description:Inverse agonist activity at human cannabinoid CB1R expressed in CHO cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50259492(5-tert-butyl-8-(2-chlorophenyl)-9-(4-(trifluoromet...)
Affinity DataIC50:  1.10nMAssay Description:Inverse agonist activity at human cannabinoid CB1R expressed in CHO cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50160100(2-(3,4-difluorobenzyloxy)-5-(4-chlorophenyl)-6-(2,...)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory concentration tested against human Cannabinoid receptor 1 (hCB1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50160100(2-(3,4-difluorobenzyloxy)-5-(4-chlorophenyl)-6-(2,...)
Affinity DataIC50:  1.30nMAssay Description:Binding affinity at CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50160115(5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-2-(3,4...)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory concentration tested against human Cannabinoid receptor 1 (hCB1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50160137(2-Benzyloxy-5-(4-chloro-phenyl)-6-(2,4-dichloro-ph...)
Affinity DataIC50:  1.40nMAssay Description:Inhibitory concentration tested against human Cannabinoid receptor 1 (hCB1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50160131(5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-2-(3,4...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory concentration tested against human Cannabinoid receptor 1 (hCB1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50160095(5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-2-(3,4...)
Affinity DataIC50:  1.70nMAssay Description:Inhibitory concentration tested against human Cannabinoid receptor 1 (hCB1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50160132(5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-2-(3,4...)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory concentration tested against human Cannabinoid receptor 1 (hCB1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50160143(5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-2-(3,5...)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory concentration tested against human Cannabinoid receptor 1 (hCB1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50259223(2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)...)
Affinity DataIC50:  1.90nMAssay Description:Inverse agonist activity at human cannabinoid CB1R expressed in CHO cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50160145(2-Butoxy-5-(4-chloro-phenyl)-6-(2,4-dichloro-pheny...)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory concentration tested against human Cannabinoid receptor 1 (hCB1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50160097(5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-2-(3,4...)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory concentration tested against human Cannabinoid receptor 1 (hCB1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50259339(5-tert-butyl-8-(2-chlorophenyl)-9-(4-chlorophenyl)...)
Affinity DataIC50:  1.90nMAssay Description:Inverse agonist activity at human cannabinoid CB1R expressed in CHO cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50259224(2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)...)
Affinity DataIC50:  2.20nMAssay Description:Inverse agonist activity at human cannabinoid CB1R expressed in CHO cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50176420(CHEMBL202169 | N-(3-acetyl-1-benzyl-6-(4-chlorophe...)
Affinity DataIC50:  2.30nMAssay Description:Binding affinity at the CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50176424(CHEMBL201388 | N-(3-acetyl-6-(4-chlorophenyl)-7-(2...)
Affinity DataIC50:  2.30nMAssay Description:Binding affinity at the CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50259225(CHEMBL513648 | N,2-di-tert-butyl-7-(2-chlorophenyl...)
Affinity DataIC50:  2.70nMAssay Description:Inverse agonist activity at human cannabinoid CB1R expressed in CHO cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50160103(5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-2-(2,4...)
Affinity DataIC50:  2.70nMAssay Description:Inhibitory concentration tested against human Cannabinoid receptor 1 (hCB1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50160136(5-(4-Chloro-phenyl)-2-cyclohexylmethoxy-6-(2,4-dic...)
Affinity DataIC50:  2.90nMAssay Description:Inhibitory concentration tested against human Cannabinoid receptor 1 (hCB1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50259491(5-tert-butyl-8-(2-chlorophenyl)-9-(4-methoxyphenyl...)
Affinity DataIC50:  3nMAssay Description:Inverse agonist activity at human cannabinoid CB1R expressed in CHO cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50160099(5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-2-(4-f...)
Affinity DataIC50:  3.10nMAssay Description:Inhibitory concentration tested against human Cannabinoid receptor 1 (hCB1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50160125(5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-2-(3,4...)
Affinity DataIC50:  3.10nMAssay Description:Inhibitory concentration tested against human Cannabinoid receptor 1 (hCB1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50259392(2-(5-tert-butyl-9-(4-chlorophenyl)-3-oxo-2,3-dihyd...)
Affinity DataIC50:  3.20nMAssay Description:Inverse agonist activity at human cannabinoid CB1R expressed in CHO cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50160108(5-(4-Chloro-phenyl)-6-(2,4-dichloro-phenyl)-2-(4-t...)
Affinity DataIC50:  3.40nMAssay Description:Inhibitory concentration tested against human Cannabinoid receptor 1 (hCB1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50160117(5-(4-Chloro-phenyl)-2-cyclohexylmethoxy-6-(2,4-dic...)
Affinity DataIC50:  3.40nMAssay Description:Inhibitory concentration tested against human Cannabinoid receptor 1 (hCB1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50204178(5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)-2-(3,4-d...)
Affinity DataIC50:  3.5nMAssay Description:Binding affinity at CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50160113(2-Benzyloxy-5-(4-chloro-phenyl)-6-(2,4-dichloro-ph...)
Affinity DataIC50:  3.5nMAssay Description:Inhibitory concentration tested against human Cannabinoid receptor 1 (hCB1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50176431(CHEMBL371252 | N-(3-acetyl-6-(4-chlorophenyl)-7-(2...)
Affinity DataIC50:  3.70nMAssay Description:Binding affinity at the CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50204174(5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)-2-(3,4-d...)
Affinity DataIC50:  3.70nMAssay Description:Binding affinity at CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50204174(5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)-2-(3,4-d...)
Affinity DataIC50:  3.70nMAssay Description:Inverse agonist activity at cannabinoid CB1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50204180(6-(2-chlorophenyl)-5-(4-chlorophenyl)-2-(4-(3,5-di...)
Affinity DataIC50:  3.80nMAssay Description:Binding affinity at CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50204179(5-(4-chlorophenyl)-2-(3,5-dichlorophenoxy)-6-(2,4-...)
Affinity DataIC50:  3.90nMAssay Description:Binding affinity at CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50204185(2-(3-chlorophenoxy)-5-(4-chlorophenyl)-6-(2,4-dich...)
Affinity DataIC50:  4nMAssay Description:Binding affinity at CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50161572(5-(4-Chloro-phenyl)-4-(2,4-dichloro-phenyl)-1-meth...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration against human recombinant cannabinoid receptor type 1 expressed in Chinese Hamster Ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50161569(5-(4-Chloro-phenyl)-4-(2,4-dichloro-phenyl)-1-ethy...)
Affinity DataIC50:  4.10nMAssay Description:Inhibitory concentration against human recombinant cannabinoid receptor type 1 expressed in Chinese Hamster Ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50259269(2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)...)
Affinity DataIC50:  4.10nMAssay Description:Inverse agonist activity at human cannabinoid CB1R expressed in CHO cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50160092(5-(4-Chloro-phenyl)-2-cyclohexylmethoxy-6-(2,4-dic...)
Affinity DataIC50:  5.20nMAssay Description:Inhibitory concentration tested against human Cannabinoid receptor 1 (hCB1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50176423(CHEMBL202064 | N-(3-acetyl-6-(4-chlorophenyl)-7-(2...)
Affinity DataIC50:  5.20nMAssay Description:Binding affinity at the CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50161585(4,5-Bis-(2,4-dichloro-phenyl)-1-methyl-1H-imidazol...)
Affinity DataIC50:  5.20nMAssay Description:Inhibitory concentration against human recombinant cannabinoid receptor type 1 expressed in Chinese Hamster Ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50204194(5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)-2-(3,4-d...)
Affinity DataIC50:  5.60nMAssay Description:Binding affinity at CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50204187(2-(1H-benzo[d][1,2,3]triazol-1-yl)-5-(4-chlorophen...)
Affinity DataIC50:  5.70nMAssay Description:Binding affinity at CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50204176(CHEMBL247910 | N-(2-(5-(4-chlorophenyl)-3-cyano-6-...)
Affinity DataIC50:  5.70nMAssay Description:Binding affinity at CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50204173(6-(2-chlorophenyl)-5-(4-chlorophenyl)-2-(3,3-dimet...)
Affinity DataIC50:  5.90nMAssay Description:Binding affinity at CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50259390(4-(5-tert-butyl-8-(2-chlorophenyl)-3-oxo-2,3-dihyd...)
Affinity DataIC50:  5.90nMAssay Description:Inverse agonist activity at human cannabinoid CB1R expressed in CHO cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50259140(2-tert-butyl-6-(4-chlorophenyl)-7-(2,4-dichlorophe...)
Affinity DataIC50:  6nMAssay Description:Inverse agonist activity at human cannabinoid CB1R expressed in CHO cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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