TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Pipeline Therapeutics
Curated by ChEMBL
Pipeline Therapeutics
Curated by ChEMBL
Affinity DataKi: 0.140nMAssay Description:Displacement of [3H]NMS from human recombinant muscarinic receptor M1 expressed in CHO-K1 cell membranes assessed as inhibition constant incubated fo...More data for this Ligand-Target Pair
Affinity DataKi: 0.158nMAssay Description:Displacement of [125I]-DOI from recombinant human 5HT2CR transfected in human HEK293 cells incubated for 45 mins by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.200nM ΔG°: -57.6kJ/mole EC50: 5.10nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
Affinity DataKi: 0.251nMAssay Description:Displacement of [125I]-DOI from recombinant human 5HT2CR transfected in human HEK293 cells incubated for 45 mins by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nM ΔG°: -56.5kJ/mole EC50: 5.70nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
Affinity DataKi: 0.316nMAssay Description:Displacement of [125I]-DOI from recombinant human 5HT2CR transfected in human HEK293 cells incubated for 45 mins by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.316nMAssay Description:Displacement of [125I]DOI from recombinant human 5-HT2C receptor expressed in HEK293 cell membranes after 1 hr by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.340nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.340nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.398nMAssay Description:Displacement of [125I]DOI from recombinant human 5-HT2C receptor expressed in HEK293 cell membranes after 1 hr by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.398nMAssay Description:Displacement of [125I]DOI from recombinant human 5-HT2C receptor expressed in HEK293 cell membranes after 1 hr by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Binding affinity for human progesterone receptor isoform A expressed in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Binding affinity for human progesterone receptor isoform A expressed in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.420nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.480nMAssay Description:Binding affinity for human progesterone receptor isoform A expressed in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.490nMAssay Description:Binding affinity for human progesterone receptor isoform A expressed in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Binding affinity for human progesterone receptor isoform A expressed in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.501nMAssay Description:Displacement of [125I]-DOI from recombinant human 5HT2CR transfected in human HEK293 cells incubated for 45 mins by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.501nMAssay Description:Displacement of [125I]-DOI from recombinant human 5HT2CR transfected in human HEK293 cells incubated for 45 mins by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.550nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.590nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2C receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.610nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.620nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.620nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.631nMAssay Description:Displacement of [125I]DOI from recombinant human 5-HT2A receptor expressed in HEK293 cell membranes after 1 hr by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.631nMAssay Description:Displacement of [125I]DOI from recombinant human 5-HT2C receptor expressed in HEK293 cell membranes after 1 hr by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.631nMAssay Description:Displacement of [125I]-DOI from recombinant human 5HT2CR transfected in human HEK293 cells incubated for 45 mins by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.631nMAssay Description:Displacement of [125I]DOI from recombinant human 5-HT2C receptor expressed in HEK293 cell membranes after 1 hr by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.660nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.660nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.710nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.794nMAssay Description:Displacement of [125I]DOI from recombinant human 5-HT2C receptor expressed in HEK293 cell membranes after 1 hr by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2C receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2C receptor (unknown origin)More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Pipeline Therapeutics
Curated by ChEMBL
Pipeline Therapeutics
Curated by ChEMBL
Affinity DataKi: 0.840nMAssay Description:Displacement of [3H]NMS from human recombinant muscarinic receptor M3 expressed in CHO-K1 cell membranes assessed as inhibition constant incubated fo...More data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2C receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Binding affinity at human progesterone receptor.More data for this Ligand-Target Pair
Affinity DataKi: 1.19nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nM ΔG°: -53.0kJ/mole EC50: 6.40nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
Affinity DataKi: 1.28nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]-DOI from recombinant human 5HT2AR transfected in human HEK293 cells incubated for 45 mins by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 1.39nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2C receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1.41nMAssay Description:Radioligand binding assays were performed using the commercially available 5-HT2 receptor agonist [125I]DOI as the radioligand and nonspecific bindin...More data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair