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Found 97 with Last Name = 'sharik' and Initial = 'ss'
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM126826(US8785467, 1-29)
Affinity DataKi:  0.00820nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM126825(US8785467, 1-27)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50315401((R)-1-((2'-oxo-1',2',6,8-tetrahydrospiro[cyclopent...)
Affinity DataKi:  0.0230nMAssay Description:Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50254445((S)-2-(2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM126827(US8785467, 1-32)
Affinity DataKi:  0.0400nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124648(CHEMBL3622901)
Affinity DataKi:  0.0470nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124649(CHEMBL3622902)
Affinity DataKi:  0.0550nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50315409(2a-ethyl-1-(((R)-2'-oxo-1',2',6,8-tetrahydrospiro[...)
Affinity DataKi:  0.0720nMAssay Description:Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124650(CHEMBL3622903)
Affinity DataKi:  0.110nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50315407(2a-methyl-1-(((R)-2'-oxo-1',2',6,8-tetrahydrospiro...)
Affinity DataKi:  0.120nMAssay Description:Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50315400((S)-1-((3'-methyl-2',5'-dioxo-6,8-dihydrospiro[cyc...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124651(CHEMBL3622904)
Affinity DataKi:  0.370nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50315403((R)-6-methyl-1-((2'-oxo-1',2',6,8-tetrahydrospiro[...)
Affinity DataKi:  0.410nMAssay Description:Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50246422((R)-2-(2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5...)
Affinity DataKi:  0.510nMAssay Description:Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50315406((4'S)-3'-methyl-2-((2a-methyl-4-oxo-2a,3,4,5-tetra...)
Affinity DataKi:  0.520nMAssay Description:Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50315405(1-(((R)-2'-oxo-1',2',6,8-tetrahydrospiro[cyclopent...)
Affinity DataKi:  0.550nMAssay Description:Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50315408((4'S)-2-((2a-ethyl-4-oxo-2a,3,4,5-tetrahydropyrrol...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50315399((R)-2-((2-oxo-3,4-dihydroquinolin-1(2H)-yl)methyl)...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50315404((4'S)-3'-methyl-2-((4-oxo-2a,3,4,5-tetrahydropyrro...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124644(CHEMBL3622894)
Affinity DataKi:  2nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50315402((S)-6-methyl-1-((3'-methyl-2',5'-dioxo-6,8-dihydro...)
Affinity DataKi:  3nMAssay Description:Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124629(CHEMBL3622879)
Affinity DataKi:  4.80nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124641(CHEMBL3622891)
Affinity DataKi:  5.10nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124642(CHEMBL3622892)
Affinity DataKi:  8.5nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50315398((S)-3'-methyl-2-((2-oxo-3,4-dihydroquinolin-1(2H)-...)
Affinity DataKi:  8.90nMAssay Description:Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124646(CHEMBL3622896)
Affinity DataKi:  9nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124638(CHEMBL3622888)
Affinity DataKi:  10nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124643(CHEMBL3622893)
Affinity DataKi:  12nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50315397((R)-3'-methyl-2-((2-oxo-3-(pyridin-2-yl)-2,3-dihyd...)
Affinity DataKi:  17nMAssay Description:Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124639(CHEMBL3622889)
Affinity DataKi:  18nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50195956((R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imida...)
Affinity DataKi:  20nMAssay Description:Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124635(CHEMBL3622885)
Affinity DataKi:  26nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124701(CHEMBL3621552)
Affinity DataKi:  37nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124627(CHEMBL3622877)
Affinity DataKi:  38nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124631(CHEMBL3622881)
Affinity DataKi:  51nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50315392((R)-N-(4'-fluoro-3-methyl-2,5-dioxo-1',3'-dihydros...)
Affinity DataKi:  55nMAssay Description:Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124633(CHEMBL3622883)
Affinity DataKi:  130nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124700(CHEMBL3621551)
Affinity DataKi:  180nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50315396(3'-methyl-2-((2-oxo-3-(pyridin-2-yl)-2,3-dihydro-1...)
Affinity DataKi:  185nMAssay Description:Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124703(CHEMBL3621554)
Affinity DataKi:  200nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124626(CHEMBL3622876)
Affinity DataKi:  220nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50315394((S)-3-methyl-2'-((2-oxo-3-(pyridin-2-yl)-2,3-dihyd...)
Affinity DataKi:  320nMAssay Description:Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50315394((S)-3-methyl-2'-((2-oxo-3-(pyridin-2-yl)-2,3-dihyd...)
Affinity DataKi:  320nMAssay Description:Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124647(CHEMBL3622897)
Affinity DataKi:  400nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124628(CHEMBL3622878)
Affinity DataKi:  540nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124645(CHEMBL3622895)
Affinity DataKi:  590nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124698(CHEMBL3621549)
Affinity DataKi:  680nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50315393((S)-N-(5'-fluoro-3-methyl-2,5-dioxo-1',3'-dihydros...)
Affinity DataKi:  720nMAssay Description:Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124632(CHEMBL3622882)
Affinity DataKi:  810nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124697(CHEMBL3621548)
Affinity DataKi:  880nMAssay Description:Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assayMore data for this Ligand-Target Pair
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