Compile Data Set for Download or QSAR
maximum 50k data
Found 5465 with Last Name = 'shaw' and Initial = 'a'
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342639(CHEMBL1770729 | N-((6S,9R)-6-(2,3-difluorophenyl)-...)
Affinity DataKi:  0.0360nMAssay Description:Displacement of [125I]-CGRP from human recombinant CGRP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342638(CHEMBL1770728 | N-((6S,9R)-6-(2,3-difluorophenyl)-...)
Affinity DataKi:  0.0390nMAssay Description:Displacement of [125I]-CGRP from human recombinant CGRP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342625(CHEMBL1770715 | N-((6S,9R)-6-(2,3-difluorophenyl)-...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [125I]-CGRP from human recombinant CGRP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342636(CHEMBL1770726 | N-((6S,9R)-6-(2,3-difluorophenyl)-...)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [125I]-CGRP from human recombinant CGRP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342634(CHEMBL1770724 | N-((6S,9R)-6-(2,3-difluorophenyl)-...)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [125I]-CGRP from human recombinant CGRP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091753(CHEMBL405854 | H-Ser-Leu-Arg-Arg-Ser-Ser-cyclic(Cy...)
Affinity DataKi:  0.0590nMAssay Description:Displacement of [125I]- ANP from the Atrial Natriuretic Peptide Clearance Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061031((S)-1-[(S)-2-(4-Benzenesulfonylaminocarbonyl-benzo...)
Affinity DataKi:  0.0600nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342630(CHEMBL1770720 | N-((6S,9R)-6-(2,3-difluorophenyl)-...)
Affinity DataKi:  0.0700nMAssay Description:Displacement of [125I]-CGRP from human recombinant CGRP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50175518((3R,7S)-7-((R)-2-Mercapto-3-phenyl-propionylamino)...)
Affinity DataKi:  0.0700nMAssay Description:Compound was tested for inhibition of neutral endopeptidase (NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091751(CHEMBL411542 | Cyclic-(Cys-Phe-Gly-Gly-Arg-Ile-Asp...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]- ANP from the Atrial Natriuretic Peptide Clearance Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091751(CHEMBL411542 | Cyclic-(Cys-Phe-Gly-Gly-Arg-Ile-Asp...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342633(CHEMBL1770723 | N-((6S,9R)-6-(2,3-difluorophenyl)-...)
Affinity DataKi:  0.140nMAssay Description:Displacement of [125I]-CGRP from human recombinant CGRP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342612(CHEMBL1770557 | N-((6S,9R)-6-(2,3-difluorophenyl)-...)
Affinity DataKi:  0.140nMAssay Description:Displacement of [125I]-CGRP from human recombinant CGRP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342637(CHEMBL1770727 | N-((6S,9R)-6-(2,3-difluorophenyl)-...)
Affinity DataKi:  0.160nMAssay Description:Displacement of [125I]-CGRP from human recombinant CGRP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224426(CHEMBL238276 | N-{(3R,6S)-6-(2,3-difluorophenyl)-2...)
Affinity DataKi:  0.190nMAssay Description:Displacement of [125I]CGPR from human CL receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342632(CHEMBL1770722 | N-((6S,9R)-6-(2,3-difluorophenyl)-...)
Affinity DataKi:  0.190nMAssay Description:Displacement of [125I]-CGRP from human recombinant CGRP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50306528((6aR,10aR)-6,6,9-trimethyl-3-(2-methyloctan-2-yl)-...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]CP-55940 from CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50001285((E)-3-((3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)(...)
Affinity DataKi:  0.200nMAssay Description:Compound was evaluated for its ability to displace [3H]-LTD4 from Cysteinyl leukotriene D4 receptor in guinea pig lung membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50306528((6aR,10aR)-6,6,9-trimethyl-3-(2-methyloctan-2-yl)-...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]CP-55940 from CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342635(CHEMBL1770725 | N-((6S,9R)-6-(2,3-difluorophenyl)-...)
Affinity DataKi:  0.290nMAssay Description:Displacement of [125I]-CGRP from human recombinant CGRP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224419(CHEMBL237662 | N-[(3R,6S)-6-(2,3-difluorophenyl)-1...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I]CGPR from human CL receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50009075(CHEMBL22033 | ICI 198615 | ICI-198615 | [1-(4-Benz...)
Affinity DataKi:  0.300nMAssay Description:Compound was evaluated for its ability to displace [3H]-LTD4 from LTD4 receptor in guinea pig lung membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091758((S)-N-[(S)-4-Guanidino-1-((S)-2-methyl-butylcarbam...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I]- ANP from the Atrial Natriuretic Peptide Clearance Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091758((S)-N-[(S)-4-Guanidino-1-((S)-2-methyl-butylcarbam...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50009073(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
Affinity DataKi:  0.300nMAssay Description:Compound was evaluated for its ability to displace [3H]-LTD4 from Cysteinyl leukotriene D4 receptor in guinea pig lung membranesMore data for this Ligand-Target Pair
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061047(((S)-2,2-Difluoro-5-methyl-4-{[(S)-1-((S)-3-methyl...)
Affinity DataKi:  0.350nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061028((S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-but...)
Affinity DataKi:  0.350nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061043(CHEMBL106592 | [(S)-1-((S)-2-{(S)-3,3-Difluoro-1-i...)
Affinity DataKi:  0.350nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342624(CHEMBL1770714 | N-((6S,9R)-6-(2,3-difluorophenyl)-...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [125I]-CGRP from human recombinant CGRP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061037(CHEMBL302961 | {(S)-1-[(S)-2-((S)-3-Carbamoyl-3,3-...)
Affinity DataKi:  0.380nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091752((S)-3-{(2S,3S)-2-[(S)-5-Guanidino-2-(2-{4-[(naphth...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091752((S)-3-{(2S,3S)-2-[(S)-5-Guanidino-2-(2-{4-[(naphth...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I]- ANP from the Atrial Natriuretic Peptide Clearance Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342629(CHEMBL1770719 | N-((6S,9R)-6-(2,3-difluorophenyl)-...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I]-CGRP from human recombinant CGRP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50289194((S)-2-[(S)-4-((R)-2-Mercapto-3-phenyl-propionylami...)
Affinity DataKi:  0.400nMAssay Description:Compound was tested for inhibition of neutral endopeptidase (NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM154981(US9000043, 1)
Affinity DataKi:  0.450nMpH: 7.4Assay Description:hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genban...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091761((S)-N-[(S)-4-Guanidino-1-((S)-2-methyl-butylcarbam...)
Affinity DataKi:  0.480nMAssay Description:Displacement of [125I]- ANP from the Atrial Natriuretic Peptide Clearance Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342631(CHEMBL1770721 | N-((6S,9R)-6-(2,3-difluorophenyl)-...)
Affinity DataKi:  0.480nMAssay Description:Displacement of [125I]-CGRP from human recombinant CGRP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 3(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091757(CHEMBL264744 | Cyclic-(Cys-Phe-Gly-Gly-Ala-Ile-Asp...)
Affinity DataKi:  0.490nMAssay Description:Displacement of [125I]- ANP from the Atrial Natriuretic Peptide Clearance Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091757(CHEMBL264744 | Cyclic-(Cys-Phe-Gly-Gly-Ala-Ile-Asp...)
Affinity DataKi:  0.490nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224413(CHEMBL392634 | N-[(3R,6S)-6-(2,3-difluorophenyl)-1...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [125I]CGPR from human CL receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50224430(CHEMBL392636 | N-{(3R,6S)-6-(2,3-difluorophenyl)-1...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [125I]CGPR from human CL receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031210(2-((S)-2-{[(S)-1-((S)-2-Benzyloxycarbonylamino-3-m...)
Affinity DataKi:  0.580nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342626(CHEMBL1770716 | N-((6S,9R)-6-(2,3-difluorophenyl)-...)
Affinity DataKi:  0.610nMAssay Description:Displacement of [125I]-CGRP from human recombinant CGRP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342628(CHEMBL1770718 | N-((6S,9R)-6-(2,3-difluorophenyl)-...)
Affinity DataKi:  0.620nMAssay Description:Displacement of [125I]-CGRP from human recombinant CGRP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342627(CHEMBL1770717 | N-((6S,9R)-6-(2,3-difluorophenyl)-...)
Affinity DataKi:  0.630nMAssay Description:Displacement of [125I]-CGRP from human recombinant CGRP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061035(2-((S)-3-Methyl-2-{[(S)-1-((S)-3-methyl-2-phenoxyc...)
Affinity DataKi:  0.640nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061044(2-((S)-3-Methyl-2-{[(S)-1-((S)-3-methyl-2-phenoxyc...)
Affinity DataKi:  0.640nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtrial natriuretic peptide receptor 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50091753(CHEMBL405854 | H-Ser-Leu-Arg-Arg-Ser-Ser-cyclic(Cy...)
Affinity DataKi:  0.650nMAssay Description:Displacement of [125I]- ANP from the Atrial natriuretic peptide receptor A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061049(2-[(S)-2-({(S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3...)
Affinity DataKi:  0.650nMAssay Description:Binding affinity for human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342623(CHEMBL1770568 | N-((6S,9R)-6-(2,3-difluorophenyl)-...)
Affinity DataKi:  0.690nMAssay Description:Displacement of [125I]-CGRP from human recombinant CGRP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 5465 total ) | Next | Last >>
Jump to: