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Found 246 with Last Name = 'shelat' and Initial = 'aa'
TargetPantothenate kinase 3(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50071456(CHEMBL3410246)
Affinity DataIC50:  25nMAssay Description:Inhibition of purified human Pank3 using d-[1-14C]pantothenate as substrate after 10 mins by radiochemical enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant human BRD2 bromodomain 2 (342 to 460 residues) using biotin labeled peptide substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of California

Curated by ChEMBL
LigandPNGBDBM50268555(6-(3-(furan-3-yl)benzylamino)-9-(3-hydroxypropyl)-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPantothenate kinase 1(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50071456(CHEMBL3410246)
Affinity DataIC50:  70nMAssay Description:Inhibition of purified human Pank1beta using d-[1-14C]pantothenate as substrate after 10 mins by radiochemical enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPantothenate kinase 2, mitochondrial(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50071456(CHEMBL3410246)
Affinity DataIC50:  92nMAssay Description:Inhibition of purified human Pank2 using d-[1-14C]pantothenate as substrate after 10 mins by radiochemical enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPantothenate kinase 3(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50071455(CHEMBL3410245)
Affinity DataIC50:  120nMAssay Description:Inhibition of Pank3 (unknown origin) by Kinase Glo HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPantothenate kinase 1(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50071456(CHEMBL3410246)
Affinity DataIC50:  140nMAssay Description:Inhibition of Pank1beta (unknown origin) by Kinase Glo HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50365262((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...)
Affinity DataIC50:  170nMAssay Description:Inhibition of recombinant human BRD2 bromodomain 2 (342 to 460 residues) using biotin labeled peptide substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPantothenate kinase 3(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50071454(CHEMBL3410244)
Affinity DataIC50:  180nMAssay Description:Inhibition of Pank3 (unknown origin) by Kinase Glo HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50300772(6-(3-(1H-indol-5-yl)benzylamino)-9-(3-hydroxypropy...)
Affinity DataIC50:  190nMAssay Description:Inhibition of human liver cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPantothenate kinase 1(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50071449(CHEMBL3410398)
Affinity DataIC50:  190nMAssay Description:Inhibition of Pank1beta (unknown origin) by Kinase Glo HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of California

Curated by ChEMBL
LigandPNGBDBM50268557(9-(3-hydroxypropyl)-6-(3-(thiophen-3-yl)benzylamin...)
Affinity DataIC50:  240nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPantothenate kinase 1(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50071469(CHEMBL3410256)
Affinity DataIC50:  240nMAssay Description:Inhibition of Pank1beta (unknown origin) by Kinase Glo HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of California

Curated by ChEMBL
LigandPNGBDBM50300773(6-(3-(1H-indol-6-yl)benzylamino)-9-(3-hydroxypropy...)
Affinity DataIC50:  260nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of California

Curated by ChEMBL
LigandPNGBDBM50268616(9-(3-hydroxypropyl)-6-(3-(pyridin-3-yl)benzylamino...)
Affinity DataIC50:  260nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B-like cysteine protease(Trypanosoma brucei)
University of California San Francisco

LigandPNGBDBM22097(6-{[(3,4-dichlorophenyl)methyl]amino}-9-(3-hydroxy...)
Affinity DataIC50:  270nMT: 2°CAssay Description:Enzyme activity was assayed in a 96-well plate format. TbcatB was incubated with inhibitor compound at room temperature for 20 min before the additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPantothenate kinase 1(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50071382(CHEMBL1555019)
Affinity DataIC50:  280nMAssay Description:Inhibition of Pank1beta (unknown origin) by Kinase Glo HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of California

Curated by ChEMBL
LigandPNGBDBM50268554(6-(3-(furan-2-yl)benzylamino)-9-(3-hydroxypropyl)-...)
Affinity DataIC50:  310nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPantothenate kinase 3(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50071453(CHEMBL3410400)
Affinity DataIC50:  350nMAssay Description:Inhibition of Pank3 (unknown origin) by Kinase Glo HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPantothenate kinase 3(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50071456(CHEMBL3410246)
Affinity DataIC50:  360nMAssay Description:Inhibition of Pank3 (unknown origin) by Kinase Glo HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50365262((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...)
Affinity DataIC50:  370nMAssay Description:Inhibition of recombinant human BRD2 bromodomain 1 (49 to 170 residues) using biotin labeled peptide substrate preincubated for 15 mins followed by s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of California

Curated by ChEMBL
LigandPNGBDBM50300774(CHEMBL570364 | N-(3'-((2-cyano-9-(3-hydroxypropyl)...)
Affinity DataIC50:  400nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50300774(CHEMBL570364 | N-(3'-((2-cyano-9-(3-hydroxypropyl)...)
Affinity DataIC50:  400nMAssay Description:Inhibition of human liver cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50452557(CHEMBL4206677 | US11028051, Cmpd 55)
Affinity DataIC50:  410nMAssay Description:Inhibition of recombinant human BRD2 bromodomain 2 (342 to 460 residues) using biotin labeled peptide substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50300773(6-(3-(1H-indol-6-yl)benzylamino)-9-(3-hydroxypropy...)
Affinity DataIC50:  460nMAssay Description:Inhibition of human liver cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50268557(9-(3-hydroxypropyl)-6-(3-(thiophen-3-yl)benzylamin...)
Affinity DataIC50:  480nMAssay Description:Inhibition of human liver cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of California

Curated by ChEMBL
LigandPNGBDBM50300772(6-(3-(1H-indol-5-yl)benzylamino)-9-(3-hydroxypropy...)
Affinity DataIC50:  500nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of California

Curated by ChEMBL
LigandPNGBDBM50268446(CHEMBL496404 | methyl 3'-((2-cyano-9-(3-hydroxypro...)
Affinity DataIC50:  500nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPantothenate kinase 1(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50071470(CHEMBL3410257)
Affinity DataIC50:  550nMAssay Description:Inhibition of Pank1beta (unknown origin) by Kinase Glo HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B-like cysteine protease(Trypanosoma brucei)
University of California San Francisco

LigandPNGBDBM22087(6-{[(4-chlorophenyl)methyl]amino}-9-(3-hydroxyprop...)
Affinity DataIC50:  570nMT: 2°CAssay Description:Enzyme activity was assayed in a 96-well plate format. TbcatB was incubated with inhibitor compound at room temperature for 20 min before the additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50268555(6-(3-(furan-3-yl)benzylamino)-9-(3-hydroxypropyl)-...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human liver cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50452551(CHEMBL4209110 | US11028051, Cmpd 50)
Affinity DataIC50:  610nMAssay Description:Inhibition of recombinant human BRD2 bromodomain 2 (342 to 460 residues) using biotin labeled peptide substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetPantothenate kinase 3(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50071469(CHEMBL3410256)
Affinity DataIC50:  620nMAssay Description:Inhibition of Pank3 (unknown origin) by Kinase Glo HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPantothenate kinase 1(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50071453(CHEMBL3410400)
Affinity DataIC50:  640nMAssay Description:Inhibition of Pank1beta (unknown origin) by Kinase Glo HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50300781(6-((3'-chlorobiphenyl-3-yl)methylamino)-9-(3-hydro...)
Affinity DataIC50:  700nMAssay Description:Inhibition of human liver cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of California

Curated by ChEMBL
LigandPNGBDBM50268553(9-(3-hydroxypropyl)-6-(3-(naphthalen-2-yl)benzylam...)
Affinity DataIC50:  700nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of California

Curated by ChEMBL
LigandPNGBDBM50268668(6-(biphenyl-3-ylmethylamino)-9-(3-hydroxypropyl)-9...)
Affinity DataIC50:  700nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50:  720nMAssay Description:Inhibition of recombinant human BRD2 bromodomain 1 (49 to 170 residues) using biotin labeled peptide substrate preincubated for 15 mins followed by s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of California

Curated by ChEMBL
LigandPNGBDBM50268556(9-(3-hydroxypropyl)-6-(3-(thiophen-2-yl)benzylamin...)
Affinity DataIC50:  800nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50268553(9-(3-hydroxypropyl)-6-(3-(naphthalen-2-yl)benzylam...)
Affinity DataIC50:  800nMAssay Description:Inhibition of human liver cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of California

Curated by ChEMBL
LigandPNGBDBM50268500(1-butyl-4-(2-(4'-ethylbiphenyl-3-yl)ethyl)-6-ethyn...)
Affinity DataIC50:  800nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50268668(6-(biphenyl-3-ylmethylamino)-9-(3-hydroxypropyl)-9...)
Affinity DataIC50:  800nMAssay Description:Inhibition of human liver cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B-like cysteine protease(Trypanosoma brucei)
University of California San Francisco

LigandPNGBDBM22100(6-{[(3,4-dichlorophenyl)methyl]amino}-9-[3-(methox...)
Affinity DataIC50:  800nMT: 2°CAssay Description:Enzyme activity was assayed in a 96-well plate format. TbcatB was incubated with inhibitor compound at room temperature for 20 min before the additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50268446(CHEMBL496404 | methyl 3'-((2-cyano-9-(3-hydroxypro...)
Affinity DataIC50:  800nMAssay Description:Inhibition of human liver cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPantothenate kinase 3(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50071449(CHEMBL3410398)
Affinity DataIC50:  830nMAssay Description:Inhibition of Pank3 (unknown origin) by Kinase Glo HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50452552(CHEMBL4205876 | US11028051, Cmpd 52)
Affinity DataIC50:  830nMAssay Description:Inhibition of recombinant human BRD2 bromodomain 2 (342 to 460 residues) using biotin labeled peptide substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50268554(6-(3-(furan-2-yl)benzylamino)-9-(3-hydroxypropyl)-...)
Affinity DataIC50:  840nMAssay Description:Inhibition of human liver cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPantothenate kinase 1(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50071459(CHEMBL3410249)
Affinity DataIC50:  850nMAssay Description:Inhibition of Pank1beta (unknown origin) by Kinase Glo HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of California

Curated by ChEMBL
LigandPNGBDBM50268444(6-((3'-(dimethylamino)biphenyl-3-yl)methylamino)-9...)
Affinity DataIC50:  900nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
University Of California

Curated by ChEMBL
LigandPNGBDBM50258405(6-((3',4'-dichlorobiphenyl-3-yl)methylamino)-9-(3-...)
Affinity DataIC50:  900nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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