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Found 221 with Last Name = 'simpson' and Initial = 'rd'
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29957(piperidine-1-carboxamide, 21t)
Affinity DataIC50:  0.100nMT: 2°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29950(piperidine-1-carboxamide, 21m)
Affinity DataIC50:  0.130nMpH: 7.0 T: 2°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29956(piperidine-1-carboxamide, 21s)
Affinity DataIC50:  0.140nMT: 2°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50382333(CHEMBL2023123)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of human recombinant renin using H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-OH as substrate assessed as formation of angiot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50305450(CHEMBL592763 | methyl (S)-4-(3-chlorophenyl)-4-((R...)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50305465(CHEMBL589647 | methyl 2-((R)-((R)-1-((S)-1-cyclohe...)
Affinity DataIC50:  0.230nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50382335(CHEMBL2024249)
Affinity DataIC50:  0.270nMAssay Description:Inhibition of human recombinant renin using H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-OH as substrate assessed as formation of angiot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50382334(CHEMBL1276678)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human recombinant renin using H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-OH as substrate assessed as formation of angiot...More data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50382333(CHEMBL2023123)
Affinity DataIC50:  0.330nMAssay Description:Inhibition of human recombinant renin using DABCYL-gamma-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate for 60 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM17950((2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethyle...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant renin using DABCYL-gamma-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate for 60 mins by fluorimetryMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50382331(CHEMBL2024248)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of human recombinant renin using H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-OH as substrate assessed as formation of angiot...More data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50382334(CHEMBL1276678)
Affinity DataIC50:  0.470nMAssay Description:Inhibition of human recombinant renin using DABCYL-gamma-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate for 60 mins by fluorimetryMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29949(piperidine-1-carboxamide, 21l)
Affinity DataIC50:  0.470nMpH: 7.0 T: 2°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50305454(CHEMBL591342 | methyl 2-((R)-((R)-1-((S)-1-cyclohe...)
Affinity DataIC50:  0.470nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29949(piperidine-1-carboxamide, 21l)
Affinity DataIC50:  0.470nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50305452(CHEMBL591578 | methyl 2-((R)-(3-chlorophenyl)((R)-...)
Affinity DataIC50:  0.480nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50305452(CHEMBL591578 | methyl 2-((R)-(3-chlorophenyl)((R)-...)
Affinity DataIC50:  0.480nMAssay Description:Inhibition of human recombinant renin using DABCYL-gamma-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate for 60 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50382331(CHEMBL2024248)
Affinity DataIC50:  0.480nMAssay Description:Inhibition of renin in human plasma assessed as formation of angiotensin1 product after 90 mins by competitive radioimmunoassayMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50305456(CHEMBL605408 | methyl 2-((R)-((R)-1-((S)-1-amino-3...)
Affinity DataIC50:  0.480nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29949(piperidine-1-carboxamide, 21l)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of recombinant human renin using of DABCYL-c-Abu-IleHis-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate after 60 to 360 mins by fluores...More data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM17950((2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethyle...)
Affinity DataIC50:  0.5nMT: 2°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306433(CHEMBL601211 | N-(adamantan-2-yl)-7-bromo-3-(carba...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50305466(CHEMBL592765 | methyl 2-((R)-(3-chloro-5-fluorophe...)
Affinity DataIC50:  0.520nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM17950((2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethyle...)
Affinity DataIC50:  0.530nMAssay Description:Inhibition of human recombinant renin using H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-OH as substrate assessed as formation of angiot...More data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM17950((2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethyle...)
Affinity DataIC50:  0.530nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50382331(CHEMBL2024248)
Affinity DataIC50:  0.560nMAssay Description:Inhibition of human recombinant renin using DABCYL-gamma-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate for 60 mins by fluorimetryMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50305457(CHEMBL591340 | methyl 2-((R)-((R)-1-((S)-1-amino-3...)
Affinity DataIC50:  0.580nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50305453(CHEMBL592762 | methyl 2-((R)-((R)-1-((S)-1-cyclohe...)
Affinity DataIC50:  0.590nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50305462(CHEMBL590623 | methyl 2-((R)-(3-chloro-2-fluorophe...)
Affinity DataIC50:  0.610nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50305461(CHEMBL606238 | methyl 2-((R)-((R)-1-((S)-1-cyclohe...)
Affinity DataIC50:  0.620nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50305463(CHEMBL590388 | methyl 2-((R)-(5-chloro-2-fluorophe...)
Affinity DataIC50:  0.620nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM17950((2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethyle...)
Affinity DataIC50:  0.650nMAssay Description:Inhibition of human recombinant renin assessed as decrease in plasma renin activity by competitive radioimmunoassay in presence of human plasmaMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM17950((2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethyle...)
Affinity DataIC50:  0.650nMAssay Description:Inhibition of renin in human plasma assessed as formation of angiotensin1 product after 90 mins by competitive radioimmunoassayMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306416(CHEMBL596620 | N-(adamantan-2-yl)-1,3-dihydrospiro...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50350915(CHEMBL1818070)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of recombinant human renin using of DABCYL-c-Abu-IleHis-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate after 60 to 360 mins by fluores...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29957(piperidine-1-carboxamide, 21t)
Affinity DataIC50:  0.730nMAssay Description:Inhibition of human recombinant renin using DABCYL-gamma-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate for 60 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306417(CHEMBL596621 | N-(adamantan-2-yl)-2,3-dihydrospiro...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306414(3-Phenyl-piperidine-1-carboxylic acid adamantan-2-...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50305452(CHEMBL591578 | methyl 2-((R)-(3-chlorophenyl)((R)-...)
Affinity DataIC50:  0.820nMAssay Description:Inhibition of renin in human plasma assessed as formation of angiotensin1 product after 90 mins by competitive radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50305452(CHEMBL591578 | methyl 2-((R)-(3-chlorophenyl)((R)-...)
Affinity DataIC50:  0.820nMAssay Description:Inhibition of human recombinant renin assessed as decrease in plasma renin activity by competitive radioimmunoassay in presence of human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50305458(CHEMBL591105 | methyl 2-((R)-(3-chlorophenyl)((R)-...)
Affinity DataIC50:  0.870nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306411(3-Benzyl-piperidine-1-carboxylic acid adamantan-2-...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM29959(piperidine-1-carboxamide, 21v)
Affinity DataIC50:  0.900nMT: 2°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306433(CHEMBL601211 | N-(adamantan-2-yl)-7-bromo-3-(carba...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of 11beta-HSD1 in human adipocytes assessed as conversion of [3H]cortisone to [3H]cortisol after 2 hrs by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306415(4-Phenyl-piperidine-1-carboxylic acid adamantan-2-...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50382333(CHEMBL2023123)
Affinity DataIC50:  1.06nMAssay Description:Inhibition of renin in human plasma assessed as formation of angiotensin1 product after 90 mins by competitive radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306412(4-Benzyl-piperidine-1-carboxylic acid adamantan-2-...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50382334(CHEMBL1276678)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of renin in human plasma assessed as formation of angiotensin1 product after 90 mins by competitive radioimmunoassayMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50350922(CHEMBL1818063)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of recombinant human renin using of DABCYL-c-Abu-IleHis-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate after 60 to 360 mins by fluores...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Vitae Pharmaceuticals

LigandPNGBDBM50350916(CHEMBL1818069)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of recombinant human renin using of DABCYL-c-Abu-IleHis-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate after 60 to 360 mins by fluores...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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