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Found 631 with Last Name = 'song' and Initial = 'r'
TargetAurora kinase A(Mus musculus (mouse))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)
Affinity DataKi:  0.300nMAssay Description:Competitive inhibition of recombinant mouse aurora kinase A expressed in insect Sf9 cells in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50433372(CHEMBL2375520)
Affinity DataKi:  1.70nMAssay Description:Competitive inhibition of human recombinant DAAO by Michaelis-Menten plot analysis in presence of D-serineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50230555(CHEMBL5267078)
Affinity DataKi:  2nMAssay Description:In vitro inhibitory activity against beta-1 adrenergic receptor determined as pA2 in guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50260725(4H-thieno[3,2-b]pyrrole-5-carboxylic acid | CHEMBL...)
Affinity DataKi:  3.5nMAssay Description:Competitive inhibition of human recombinant DAAO by Michaelis-Menten plot analysis in presence of D-serineMore data for this Ligand-Target Pair
TargetAurora kinase A(Mus musculus (mouse))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)
Affinity DataKi:  7nMAssay Description:Competitive inhibition of recombinant mouse aurora kinase A expressed in insect Sf9 cells in presence of ATPMore data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50260722(4-(4-chlorophenethyl)-1H-pyrrole-2-carboxylic acid...)
Affinity DataKi:  7.20nMAssay Description:Competitive inhibition of human recombinant DAAO by Michaelis-Menten plot analysis in presence of D-serineMore data for this Ligand-Target Pair
TargetCathepsin B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50230554(CHEMBL5283523)
Affinity DataKi:  9.40nMAssay Description:In vitro inhibitory activity against beta-1 adrenergic receptor determined as pA2 in guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50206007(3-Hydroxy-chromen-2-one | 3-hydroxy-2H-chromen-2-o...)
Affinity DataKi:  13nMAssay Description:Competitive inhibition of human recombinant DAAO by Michaelis-Menten plot analysis in presence of D-serineMore data for this Ligand-Target Pair
TargetProcathepsin L(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50230554(CHEMBL5283523)
Affinity DataKi:  13nMAssay Description:In vitro inhibitory activity against beta-1 adrenergic receptor determined as pA2 in guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50433371(CHEMBL2375519)
Affinity DataKi:  190nMAssay Description:Competitive inhibition of human recombinant DAAO by Michaelis-Menten plot analysis in presence of D-serineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM36181(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)
Affinity DataKi:  2.00E+3nMAssay Description:Competitive inhibition of human recombinant DAAO by Michaelis-Menten plot analysis in presence of D-serineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Sus scrofa (pig))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50004955(1H-Indole-2-carboxylic acid | CHEMBL278390 | Indol...)
Affinity DataKi:  3.40E+3nMAssay Description:Competitive inhibition of pig kidney DAAO in presence of D-alanineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50014323(2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE | 2-Phenyl-benzo...)
Affinity DataIC50:  0nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate incubated for 5 to 45 mins in presence of NADPH by LC/MS analysisMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Mus musculus)
Hangzhou Institute Of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50506088(CHEMBL4462143)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of CXCR2-mediated chemotaxis in mouse BAF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Hangzhou Institute Of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50302098(3-(2-(2,2-diethylhydrazinyl)-3,4-dioxocyclobut-1-e...)
Affinity DataIC50:  0.120nMAssay Description:Antagonist activity at CXCR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50546014(CHEMBL4780201)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using lipid as substrate incubated for 15 mins followed by substrate addition and measured after 60 mins ADP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using lipid as substrate incubated for 15 mins followed by substrate addition and measured after 60 mins ADP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50230550(CHEMBL5268799)
Affinity DataIC50:  0.430nMAssay Description:Binding affinity against Dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50546014(CHEMBL4780201)
Affinity DataIC50:  0.480nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using lipid as substrate incubated for 15 mins followed by substrate addition and measured after 60 mins ADP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50456923(CHEMBL4213353)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full-length human p110alpha/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50546014(CHEMBL4780201)
Affinity DataIC50:  0.580nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using lipid as substrate incubated for 15 mins followed by substrate addition and measured after 60 mins ADP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50230550(CHEMBL5268799)
Affinity DataIC50:  0.670nMAssay Description:Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using lipid as substrate incubated for 15 mins followed by substrate addition and measured after 60 mins ADP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50166256(5-[4-(4-Bromo-phenoxy)-phenyl]-5-(4-isopropyl-pipe...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity against beta-1 adrenergic receptor determined as pA2 in guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant mouse aurora kinase A expressed in insect Sf9 cells using biotin-GLRRASLG as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50341493(CHEMBL1765463 | Ethyl 6-(5-(Phenylsulfonamido)pyri...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full-length human p110alpha/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using lipid as substrate incubated for 15 mins followed by substrate addition and measured after 60 mins ADP...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50069985((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human platelet Thromboxane synthetaseMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50329819((R)-1-((2S,3R)-3-hydroxy-2-(6-phenylpicolinamido)b...)
Affinity DataIC50:  1.5nMAssay Description:Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using lipid as substrate incubated for 15 mins followed by substrate addition and measured after 60 mins ADPG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50128787(4-[4-(2-Bromo-phenyl)-3-nitro-1-pyridin-3-ylmethyl...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-RasMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50128787(4-[4-(2-Bromo-phenyl)-3-nitro-1-pyridin-3-ylmethyl...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-RasMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Hangzhou Institute Of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50506082(CHEMBL4574181)
Affinity DataIC50:  2nMAssay Description:Displacement of [125I]IL-8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Hangzhou Institute Of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50506084(CHEMBL4465379)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at CXCR2 (unknown origin) by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of EGFR (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50457968(CHEMBL4207750)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of EGFR (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50069989((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)
Affinity DataIC50:  2.40nMAssay Description:In vitro inhibition of dihydropteroate synthase from Escherichia coli.More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50230543(CHEMBL5283576)
Affinity DataIC50:  2.60nMAssay Description:Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50546014(CHEMBL4780201)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using lipid as substrate incubated for 15 mins followed by substrate addition and measured after 60 mins ADPG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50398607(ONX 0912 | OPROZOMIB | US10640533, Identification ...)
Affinity DataIC50:  3nMAssay Description:Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50093572(CHEMBL3585766)
Affinity DataIC50:  3nMAssay Description:Binding affinity against Dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50433372(CHEMBL2375520)
Affinity DataIC50:  3.10nMAssay Description:Competitive inhibition of human recombinant DAAO after 1 hr by coupled enzyme assay in presence of D-serineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50398609(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)
Affinity DataIC50:  3.40nMAssay Description:Antagonistic activity against beta-1 adrenergic receptor of isolated guinea pig atriaMore data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50230552(CHEMBL5267731)
Affinity DataIC50:  3.70nMAssay Description:Binding affinity against Dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50456924(CHEMBL4207685)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full-length human p110alpha/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50100089(2-(4-Benzoyl-benzenesulfonylmethyl)-5-phenyl-penta...)
Affinity DataIC50:  4nMAssay Description:Binding affinity against Dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Mus musculus (mouse))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)
Affinity DataIC50:  4nMAssay Description:Inhibition of mouse recombinant Aurora A kinase expressed in insect Sf9 cells by radioactive flashplate assayMore data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50230551(CHEMBL5281153)
Affinity DataIC50:  4.40nMAssay Description:In vitro inhibitory activity against beta-2 adrenergic receptor determined as pA2 in guinea pig tracheaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50230551(CHEMBL5281153)
Affinity DataIC50:  4.80nMAssay Description:Binding affinity against Dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50100089(2-(4-Benzoyl-benzenesulfonylmethyl)-5-phenyl-penta...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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