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Found 207 with Last Name = 'sorna' and Initial = 'v'
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50445346(CHEMBL3104250)
Affinity DataKi:  14nMAssay Description:Non-competitive inhibition of recombinant full-length His6-tagged LSD1 (unknown origin) using dimethylated K4N-terminal H3 peptide as substrate at 1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50445346(CHEMBL3104250)
Affinity DataKi:  32nMAssay Description:Non-competitive inhibition of recombinant full-length His6-tagged LSD1 (unknown origin) using dimethylated K4N-terminal H3 peptide as substrate at 10...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50445346(CHEMBL3104250)
Affinity DataKi:  35nMAssay Description:Non-competitive inhibition of recombinant full-length His6-tagged LSD1 (unknown origin) using dimethylated K4N-terminal H3 peptide as substrate at 3 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50445346(CHEMBL3104250)
Affinity DataKi:  35nMAssay Description:Non-competitive inhibition of recombinant full-length His6-tagged LSD1 (unknown origin) using dimethylated K4N-terminal H3 peptide as substrate at 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50445346(CHEMBL3104250)
Affinity DataKi:  55nMAssay Description:Non-competitive inhibition of recombinant full-length His6-tagged LSD1 (unknown origin) using dimethylated K4N-terminal H3 peptide as substrate at 10...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University of Utah Research Foundation

US Patent
LigandPNGBDBM214693(US9296703, 1)
Affinity DataIC50:  4nMT: 2°CAssay Description:The primary assay for compound inhibitory activity was the ADP generation assay described herein. Test compounds were diluted to desired concentratio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Brigham Young University

Curated by ChEMBL
LigandPNGBDBM17004(BX-517 | Indolinone based inhibitor, 4i | [(3Z)-2-...)
Affinity DataIC50:  9nMAssay Description:Inhibition of PDK1 (unknown origin) after 1 hr in presence of Ser/Thr-07 by fluorometric assayMore data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM151608(US8987335, 9 | US9555024, 9)
Affinity DataIC50:  13nMAssay Description:The primary assay for compound inhibitory activity was the LSD1 Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, Mich.; Cayman Chem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM151611(SP-2509 | US11433053, Example HCI-2509 | US8987335...)
Affinity DataIC50:  13nMAssay Description:The primary assay for compound inhibitory activity was the LSD1 Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, Mich.; Cayman Chem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM151617(US8987335, 18)
Affinity DataIC50:  13nMAssay Description:The primary assay for compound inhibitory activity was the LSD1 Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, Mich.; Cayman Chem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM151611(SP-2509 | US11433053, Example HCI-2509 | US8987335...)
Affinity DataIC50:  13nMAssay Description:The primary assay for compound inhibitory activity was the LSD1 Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, Mich.; Cayman Chem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM151617(US8987335, 18)
Affinity DataIC50:  13nMAssay Description:The primary assay for compound inhibitory activity was the LSD1 Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, Mich.; Cayman Chem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50445346(CHEMBL3104250)
Affinity DataIC50:  13nMAssay Description:Inhibition of LSD1 (unknown origin) using dimethyl K4 peptide as substrate assessed as resorufin level by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM151608(US8987335, 9 | US9555024, 9)
Affinity DataIC50:  13nMAssay Description:The primary assay for compound inhibitory activity was the LSD1 Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, Mich.; Cayman Chem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50445347(CHEMBL3104252)
Affinity DataIC50:  14nMAssay Description:Inhibition of LSD1 (unknown origin) using dimethyl K4 peptide as substrate assessed as resorufin level by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50445348(CHEMBL3104350)
Affinity DataIC50:  19nMAssay Description:Inhibition of LSD1 (unknown origin) using dimethyl K4 peptide as substrate assessed as resorufin level by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50445349(CHEMBL3104261 | US9676701, 63 Enantiomers of 4R...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant LSD1 using dimethylated H3K4 peptide as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50445366(CHEMBL3104342)
Affinity DataIC50:  25nMAssay Description:Inhibition of human recombinant LSD1 using dimethylated H3K4 peptide as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM151623(US8987335, 24)
Affinity DataIC50:  28nMAssay Description:The primary assay for compound inhibitory activity was the LSD1 Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, Mich.; Cayman Chem...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM151623(US8987335, 24)
Affinity DataIC50:  28nMAssay Description:The primary assay for compound inhibitory activity was the LSD1 Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, Mich.; Cayman Chem...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University of Utah Research Foundation

US Patent
LigandPNGBDBM120748(US8703767, 8)
Affinity DataIC50:  33nMT: 2°CAssay Description:The primary assay for compound inhibitory activity was the ADP generation assay described herein. Test compounds were diluted to desired concentratio...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University of Utah Research Foundation

US Patent
LigandPNGBDBM120741(US8703767, 1)
Affinity DataIC50:  45nMT: 2°CAssay Description:Activity of compounds was routinely confirmed using a secondary assay as described herein. The secondary assay was a time resolved-FRET kinase assay....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University of Utah Research Foundation

US Patent
LigandPNGBDBM120748(US8703767, 8)
Affinity DataIC50:  47nMT: 2°CAssay Description:Activity of compounds was routinely confirmed using a secondary assay as described herein. The secondary assay was a time resolved-FRET kinase assay....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM151624(US8987335, 25)
Affinity DataIC50:  49nMAssay Description:The primary assay for compound inhibitory activity was the LSD1 Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, Mich.; Cayman Chem...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM151624(US8987335, 25)
Affinity DataIC50:  49nMAssay Description:The primary assay for compound inhibitory activity was the LSD1 Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, Mich.; Cayman Chem...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University of Utah Research Foundation

US Patent
LigandPNGBDBM120741(US8703767, 1)
Affinity DataIC50:  79nMT: 2°CAssay Description:The primary assay for compound inhibitory activity was the ADP generation assay described herein. Test compounds were diluted to desired concentratio...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Brigham Young University

Curated by ChEMBL
LigandPNGBDBM103938(US8569511, 1)
Affinity DataIC50:  80nMAssay Description:Inhibition of PDK1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Brigham Young University

Curated by ChEMBL
LigandPNGBDBM103938(US8569511, 1)
Affinity DataIC50:  80nMAssay Description:Inhibition of PDK1 (unknown origin) after 1 hr in presence of Ser/Thr-07 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Brigham Young University

Curated by ChEMBL
LigandPNGBDBM103938(US8569511, 1)
Affinity DataIC50:  80nMAssay Description:The secondary assay was a time resolved-FRET LanthaScreen Kinase Binding Assay. (Invitrogen Corporation, Carlsbad, Calif.). This assay evaluates the...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM227716(US9556170, 3)
Affinity DataIC50:  81nMAssay Description:Inhibition of LSD activity can be determined by a variety of both in vitro and in vivo methods known to one skilled in the art. For example, enzymati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50158877(CHEMBL3786908 | US9556170, 1)
Affinity DataIC50:  90nMAssay Description:Inhibition of LSD activity can be determined by a variety of both in vitro and in vivo methods known to one skilled in the art. For example, enzymati...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Brigham Young University

Curated by ChEMBL
LigandPNGBDBM103939(US8569511, 2)
Affinity DataIC50:  90nMAssay Description:Inhibition of PDK1 (unknown origin) after 1 hr in presence of Ser/Thr-07 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Brigham Young University

Curated by ChEMBL
LigandPNGBDBM103939(US8569511, 2)
Affinity DataIC50:  94nMAssay Description:Inhibition of PDK1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Brigham Young University

Curated by ChEMBL
LigandPNGBDBM103939(US8569511, 2)
Affinity DataIC50:  94nMAssay Description:The secondary assay was a time resolved-FRET LanthaScreen Kinase Binding Assay. (Invitrogen Corporation, Carlsbad, Calif.). This assay evaluates the...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50445345(CHEMBL3104340)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant LSD1 using dimethylated H3K4 peptide as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University of Utah Research Foundation

US Patent
LigandPNGBDBM120743(US8703767, 3)
Affinity DataIC50:  126nMT: 2°CAssay Description:Activity of compounds was routinely confirmed using a secondary assay as described herein. The secondary assay was a time resolved-FRET kinase assay....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM151610(US8987335, 11 | US9555024, 11)
Affinity DataIC50:  128nMAssay Description:The primary assay for compound inhibitory activity was the LSD1 Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, Mich.; Cayman Chem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50445344(CHEMBL3104249)
Affinity DataIC50:  128nMAssay Description:Inhibition of LSD1 (unknown origin) using dimethyl K4 peptide as substrate assessed as resorufin level by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM151610(US8987335, 11 | US9555024, 11)
Affinity DataIC50:  128nMAssay Description:The primary assay for compound inhibitory activity was the LSD1 Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, Mich.; Cayman Chem...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Brigham Young University

Curated by ChEMBL
LigandPNGBDBM103938(US8569511, 1)
Affinity DataIC50:  143nMAssay Description:The primary assay for compound inhibitory activity was the ATP depletion assay using the PDKtide substrate purchase from Millipore Corporation.More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Brigham Young University

Curated by ChEMBL
LigandPNGBDBM103939(US8569511, 2)
Affinity DataIC50:  159nMAssay Description:The primary assay for compound inhibitory activity was the ATP depletion assay using the PDKtide substrate purchase from Millipore Corporation.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University of Utah Research Foundation

US Patent
LigandPNGBDBM120742(US8703767, 2)
Affinity DataIC50:  187nMT: 2°CAssay Description:The primary assay for compound inhibitory activity was the ADP generation assay described herein. Test compounds were diluted to desired concentratio...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50445343(CHEMBL3104348 | US9555024, 4)
Affinity DataIC50:  196nMAssay Description:Inhibition of LSD1 (unknown origin) using dimethyl K4 peptide as substrate assessed as resorufin level by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50445343(CHEMBL3104348 | US9555024, 4)
Affinity DataIC50:  196nMAssay Description:The primary assay for compound inhibitory activity was the LSD1 Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, Mich.; Cayman Chem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50445343(CHEMBL3104348 | US9555024, 4)
Affinity DataIC50:  196nMAssay Description:The primary assay for compound inhibitory activity was the LSD1 Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, Mich.; Cayman Chem...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Brigham Young University

Curated by ChEMBL
LigandPNGBDBM103920(US8569511, 4)
Affinity DataIC50:  200nMAssay Description:Inhibition of PDK1 (unknown origin) after 1 hr in presence of Ser/Thr-07 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Brigham Young University

Curated by ChEMBL
LigandPNGBDBM103919(US8569511, 3)
Affinity DataIC50:  200nMAssay Description:Inhibition of PDK1 (unknown origin) after 1 hr in presence of Ser/Thr-07 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50445342(CHEMBL199600)
Affinity DataIC50:  218nMAssay Description:Inhibition of LSD1 (unknown origin) using dimethyl K4 peptide as substrate assessed as resorufin level by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM151605(US8987335, 1 | US9555024, 1)
Affinity DataIC50:  218nMAssay Description:The primary assay for compound inhibitory activity was the LSD1 Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, Mich.; Cayman Chem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM151605(US8987335, 1 | US9555024, 1)
Affinity DataIC50:  218nMAssay Description:The primary assay for compound inhibitory activity was the LSD1 Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, Mich.; Cayman Chem...More data for this Ligand-Target Pair
In DepthDetails US Patent
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