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Found 663 with Last Name = 'springer' and Initial = 'cj'
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25391(CHEMBL200622 | SB-590885 | SB590885 | [2-(4-{4-[(1...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of N-terminus His-6 tagged human B-Raf expressed in baculovirus infected insect Sf9 cellsMore data for this Ligand-Target Pair
TargetCarboxypeptidase G2(Pseudomonas aeruginosa)
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50171504((S)-2-{4-[Bis-(2-chloro-ethyl)-amino]-2,3,5,6-tetr...)
Affinity DataKi:  1.27E+5nMAssay Description:Inhibitory activity against carboxypeptidase G2 from pseudomonas RS16More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase G2(Pseudomonas aeruginosa)
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50171496((S)-2-{4-[Bis-(2-iodo-ethyl)-amino]-2,3,5,6-tetraf...)
Affinity DataKi:  2.76E+5nMAssay Description:Inhibitory activity against carboxypeptidase G2 from pseudomonas RS16More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50480105(CHEMBL496201)
Affinity DataIC50:  1nMAssay Description:Inhibition of BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50480108(CHEMBL496009)
Affinity DataIC50:  1nMAssay Description:Inhibition of BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50482454(CHEMBL1214000)
Affinity DataIC50:  2nMAssay Description:Inhibition of B-Raf V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50482455(CHEMBL1214001)
Affinity DataIC50:  2nMAssay Description:Inhibition of B-Raf V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50482509(CHEMBL1214614)
Affinity DataIC50:  3nMAssay Description:Inhibition of B-Raf V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50482510(CHEMBL1213998)
Affinity DataIC50:  3nMAssay Description:Inhibition of B-Raf V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50482489(CHEMBL1214055)
Affinity DataIC50:  3nMAssay Description:Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50307879(CHEMBL602123 | N-(2,3,4-trifluoro-5-(2-oxo-2,3-dih...)
Affinity DataIC50:  3nMAssay Description:Inhibition of cRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50363398(CHEMBL1946171)
Affinity DataIC50:  3nMAssay Description:Inhibition of wild-type B-RafMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50363398(CHEMBL1946171)
Affinity DataIC50:  3nMAssay Description:Inhibition of C-RafMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50482482(CHEMBL1214612)
Affinity DataIC50:  4nMAssay Description:Inhibition of B-Raf V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50482488(CHEMBL1213952)
Affinity DataIC50:  4nMAssay Description:Inhibition of B-Raf V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50482453(CHEMBL1213999)
Affinity DataIC50:  4nMAssay Description:Inhibition of B-Raf V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50482490(CHEMBL1214058)
Affinity DataIC50:  4nMAssay Description:Inhibition of B-Raf V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50482512(CHEMBL1214129)
Affinity DataIC50:  5nMAssay Description:Inhibition of B-Raf V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50482514(CHEMBL1213691)
Affinity DataIC50:  5nMAssay Description:Inhibition of B-Raf V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50482511(CHEMBL1214056)
Affinity DataIC50:  5nMAssay Description:Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM142606(US8933228, 8)
Affinity DataIC50:  5nMAssay Description:Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50482449(CHEMBL1213824)
Affinity DataIC50:  6nMAssay Description:Inhibition of B-Raf V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50482456(CHEMBL1214057)
Affinity DataIC50:  6nMAssay Description:Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50480091(CHEMBL523753)
Affinity DataIC50:  6nMAssay Description:Inhibition of BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50482508(CHEMBL1214617)
Affinity DataIC50:  7nMAssay Description:Inhibition of B-Raf V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50482491(CHEMBL1214133)
Affinity DataIC50:  7nMAssay Description:Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50482492(CHEMBL1214136)
Affinity DataIC50:  7nMAssay Description:Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50480123(CHEMBL496612)
Affinity DataIC50:  7nMAssay Description:Inhibition of BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50480092(CHEMBL522072)
Affinity DataIC50:  7nMAssay Description:Inhibition of BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50480112(CHEMBL496020)
Affinity DataIC50:  8nMAssay Description:Inhibition of BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM142603(US8933228, 5)
Affinity DataIC50:  8nMAssay Description:Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM142605(US8933228, 7)
Affinity DataIC50:  8nMAssay Description:Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM313753(US10167282, Compound TBAP-04)
Affinity DataIC50:  8nMAssay Description:Mutant BRAF WM266.4 Cells.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50490672(CHEMBL2336826)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant N-terminal His-tagged BRAF V600E mutant expressed in Sf9 cells using GST-tagged MEK1 and ATP as substrate incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50482476(CHEMBL1214619)
Affinity DataIC50:  10nMAssay Description:Inhibition of B-Raf V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM142604(US8933228, 6)
Affinity DataIC50:  10nMAssay Description:Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50480093(CHEMBL487717)
Affinity DataIC50:  10nMAssay Description:Inhibition of BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50482487(CHEMBL1213886)
Affinity DataIC50:  11nMAssay Description:Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50482468(CHEMBL1214440)
Affinity DataIC50:  11nMAssay Description:Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50482486(CHEMBL1213821)
Affinity DataIC50:  11nMAssay Description:Inhibition of B-Raf V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50482016(CHEMBL1091432)
Affinity DataIC50:  11nMAssay Description:Inhibition of human BRAF V600E mutant expressed in baculovirus systemMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50480124(CHEMBL496202)
Affinity DataIC50:  12nMAssay Description:Inhibition of BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50480094(CHEMBL496414)
Affinity DataIC50:  12nMAssay Description:Inhibition of BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
The Institute of Cancer Research

LigandPNGBDBM29709(Pyridoimidazolone, 5i)
Affinity DataIC50:  12nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM313751(US10167282, Compound TBAP-02)
Affinity DataIC50:  12nMAssay Description:Mutant BRAF WM266.4 Cells.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataIC50:  13nMAssay Description:Inhibition of wild-type B-RafMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50480095(CHEMBL501686)
Affinity DataIC50:  14nMAssay Description:Inhibition of BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
The Institute of Cancer Research

LigandPNGBDBM29705(Pyridoimidazolone, 5e)
Affinity DataIC50:  14nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM142599(US8933228, 1)
Affinity DataIC50:  14nMAssay Description:Inhibition of BRAF V600E mutant ERK phosphorylation in human WM266.4 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50480127(CHEMBL496203)
Affinity DataIC50:  16nMAssay Description:Inhibition of BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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