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Found 43 with Last Name = 'stappenbeck' and Initial = 'f'
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sgx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50254954(4-(3-amino-1H-indazol-5-yl)-N-tert-butyl-3-chlorob...)
Affinity DataIC50:  39nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sgx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50254911(4-(3-amino-1H-indazol-5-yl)-N-tert-butylbenzenesul...)
Affinity DataIC50:  78nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sgx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50254868(5-(2,4-dimethylthiazol-5-yl)-1H-indazol-3-amine | ...)
Affinity DataIC50:  320nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sgx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50254951(5-(4-(morpholinosulfonyl)phenyl)-1H-indazol-3-amin...)
Affinity DataIC50:  330nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sgx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50254869(5-(2-chlorophenyl)-1H-indazol-3-amine | CHEMBL4988...)
Affinity DataIC50:  370nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50433575(CHEMBL2381700)
Affinity DataIC50:  500nMAssay Description:Inhibition of integrin alphaVbeta1 (unknown origin) binding to mouse OPN-HIS after 30 mins by fibronectin mediated cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sgx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50254870(5-(3-chlorophenyl)-1H-indazol-3-amine | CHEMBL4815...)
Affinity DataIC50:  740nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sgx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50254953(4-(3-amino-7-methyl-1H-indazol-5-yl)-N-tert-butylb...)
Affinity DataIC50:  770nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sgx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50254950(5-(4-(ethylsulfonyl)phenyl)-1H-indazol-3-amine | C...)
Affinity DataIC50:  790nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sgx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50254949(5-(4-(morpholinomethyl)phenyl)-1H-indazol-3-amine ...)
Affinity DataIC50:  1.11E+3nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sgx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50254952(4-(3-amino-7-chloro-1H-indazol-5-yl)-N-tert-butylb...)
Affinity DataIC50:  1.22E+3nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sgx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50254914((4-(3-amino-1H-indazol-5-yl)phenyl)(morpholino)met...)
Affinity DataIC50:  1.57E+3nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sgx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50254831(5-phenyl-1H-indazol-3-amine | CHEMBL500779)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sgx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50254912(4-(3-amino-1H-indazol-5-yl)-N-tert-butylbenzamide ...)
Affinity DataIC50:  1.95E+3nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sgx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50254866(5-(pyridin-4-yl)-1H-indazol-3-amine | CHEMBL479620)
Affinity DataIC50:  1.95E+3nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Sgx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50254911(4-(3-amino-1H-indazol-5-yl)-N-tert-butylbenzenesul...)
Affinity DataIC50:  2.93E+3nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sgx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50254910(3-(3-amino-1H-indazol-5-yl)-N-tert-butylbenzenesul...)
Affinity DataIC50:  3.55E+3nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sgx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50254913(1-(4-(3-amino-1H-indazol-5-yl)phenyl)-3-tert-butyl...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sgx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50254871(5-(6-chloropyridin-2-yl)-1H-indazol-3-amine | CHEM...)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50433575(CHEMBL2381700)
Affinity DataIC50:  7.24E+3nMAssay Description:Inhibition of integrin alpha4beta7 (unknown origin) binding to MadCAM in human 8866 cells after 30 mins by fibronectin mediated cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sgx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50254909(5-(4-(4-methylpiperazin-1-yl)phenyl)-1H-indazol-3-...)
Affinity DataIC50:  8.58E+3nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sgx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50254865(5-(1H-pyrazol-3-yl)-1H-indazol-3-amine | CHEMBL479...)
Affinity DataIC50:  9.30E+3nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sgx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50254867(5-(3,5-dimethylisoxazol-4-yl)-1H-indazol-3-amine |...)
Affinity DataIC50:  2.86E+4nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/beta-2(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50433575(CHEMBL2381700)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of integrin alphaLbeta2 (unknown origin) binding to VCAM-1 in human 8866 cells after 30 mins by fibronectin mediated cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50433575(CHEMBL2381700)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of integrin alpha5beta1 (unknown origin) binding to VCAM-1 in human THP1 cells after 30 mins by fibronectin mediated cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sgx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50254986(5-bromo-1H-indazol-3-amine | CHEMBL465091 | EN300-...)
Affinity DataIC50:  4.09E+4nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sgx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50254987(6-bromo-1H-indazol-3-amine | CHEMBL501406)
Affinity DataIC50:  1.31E+5nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sgx Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50254864(6-phenyl-1H-indazol-3-amine | CHEMBL446576)
Affinity DataIC50:  1.45E+5nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Fate Therapeutics

Curated by ChEMBL
LigandPNGBDBM50421175(CHEMBL2086780)
Affinity DataEC50: >5.00E+3nMAssay Description:Activation of SHh in mouse Light2 cells assessed as induction of Gli-mediated luciferase activity after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Fate Therapeutics

Curated by ChEMBL
LigandPNGBDBM50421176(CHEMBL2086781)
Affinity DataEC50:  2.90E+3nMAssay Description:Activation of SHh in mouse Light2 cells assessed as induction of Gli-mediated luciferase activity after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Fate Therapeutics

Curated by ChEMBL
LigandPNGBDBM50421177(CHEMBL2086782)
Affinity DataEC50: >1.00E+4nMAssay Description:Activation of SHh in mouse Light2 cells assessed as induction of Gli-mediated luciferase activity after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Fate Therapeutics

Curated by ChEMBL
LigandPNGBDBM50421178(CHEMBL2086783)
Affinity DataEC50: >1.00E+4nMAssay Description:Activation of SHh in mouse Light2 cells assessed as induction of Gli-mediated luciferase activity after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Fate Therapeutics

Curated by ChEMBL
LigandPNGBDBM50421179(CHEMBL2086784)
Affinity DataEC50:  3.10E+3nMAssay Description:Activation of SHh in mouse Light2 cells assessed as induction of Gli-mediated luciferase activity after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Fate Therapeutics

Curated by ChEMBL
LigandPNGBDBM50421180(CHEMBL2086785)
Affinity DataEC50:  800nMAssay Description:Activation of SHh in mouse Light2 cells assessed as induction of Gli-mediated luciferase activity after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Fate Therapeutics

Curated by ChEMBL
LigandPNGBDBM50421170(CHEMBL2086775 | CHEMBL2086786)
Affinity DataEC50:  300nMAssay Description:Activation of SHh in mouse Light2 cells assessed as induction of Gli-mediated luciferase activity after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Fate Therapeutics

Curated by ChEMBL
LigandPNGBDBM50421180(CHEMBL2086785)
Affinity DataEC50:  1.10E+3nMAssay Description:Activation of SHh in mouse Light2 cells assessed as induction of Gli-mediated luciferase activity after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Fate Therapeutics

Curated by ChEMBL
LigandPNGBDBM50421180(CHEMBL2086785)
Affinity DataEC50:  1.00E+3nMAssay Description:Activation of SHh in mouse Light2 cells assessed as induction of Gli-mediated luciferase activity after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Fate Therapeutics

Curated by ChEMBL
LigandPNGBDBM50421180(CHEMBL2086785)
Affinity DataEC50:  800nMAssay Description:Activation of SHh in mouse Light2 cells assessed as induction of Gli-mediated luciferase activity after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Fate Therapeutics

Curated by ChEMBL
LigandPNGBDBM50421170(CHEMBL2086775 | CHEMBL2086786)
Affinity DataEC50:  400nMAssay Description:Activation of SHh in mouse Light2 cells assessed as induction of Gli-mediated luciferase activity after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Fate Therapeutics

Curated by ChEMBL
LigandPNGBDBM50421174(CHEMBL2086779)
Affinity DataEC50:  1.20E+3nMAssay Description:Activation of SHh in mouse Light2 cells assessed as induction of Gli-mediated luciferase activity after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Fate Therapeutics

Curated by ChEMBL
LigandPNGBDBM50421173(CHEMBL2086778)
Affinity DataEC50:  2.50E+3nMAssay Description:Activation of SHh in mouse Light2 cells assessed as induction of Gli-mediated luciferase activity after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Fate Therapeutics

Curated by ChEMBL
LigandPNGBDBM50421171(CHEMBL2086776)
Affinity DataEC50:  500nMAssay Description:Activation of SHh in mouse Light2 cells assessed as induction of Gli-mediated luciferase activity after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Fate Therapeutics

Curated by ChEMBL
LigandPNGBDBM50421172(CHEMBL2086777)
Affinity DataEC50:  6.60E+3nMAssay Description:Activation of SHh in mouse Light2 cells assessed as induction of Gli-mediated luciferase activity after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed