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Found 411 with Last Name = 'stone' and Initial = 'ea'
TargetHistidinol dehydrogenase, chloroplastic(Brassica oleracea var. capitata)
TBA

Curated by ChEMBL
LigandPNGBDBM50267976((S)-3-Amino-1-biphenyl-4-yl-4-(1H-imidazol-4-yl)-b...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of Brassica oleracea (cabbage) histidinol dehydrogenase pre-incubated for 10 min before substrate histidinol addition by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
TargetHistidinol dehydrogenase, chloroplastic(Brassica oleracea var. capitata)
TBA

Curated by ChEMBL
LigandPNGBDBM50267975((S)-3-Amino-1-(4-bromo-phenyl)-4-(1H-imidazol-4-yl...)
Affinity DataKi:  4.40nMAssay Description:Inhibition of Brassica oleracea (cabbage) histidinol dehydrogenase pre-incubated for 10 min before substrate histidinol addition by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
TargetHistidinol dehydrogenase, chloroplastic(Brassica oleracea var. capitata)
TBA

Curated by ChEMBL
LigandPNGBDBM50287735((S)-3-Amino-1-(3-amino-phenyl)-4-(1H-imidazol-4-yl...)
Affinity DataKi:  7.40nMAssay Description:Inhibition of Brassica oleracea (cabbage) histidinol dehydrogenase pre-incubated for 10 min before substrate histidinol addition by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
TargetHistidinol dehydrogenase, chloroplastic(Brassica oleracea var. capitata)
TBA

Curated by ChEMBL
LigandPNGBDBM50267972((S)-3-Amino-4-(1H-imidazol-4-yl)-1-phenyl-butan-2-...)
Affinity DataKi:  7.60nMAssay Description:Inhibition of Brassica oleracea (cabbage) histidinol dehydrogenase pre-incubated for 10 min before substrate histidinol addition by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
TargetHistone deacetylase 4 [648-1032](Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM243173((R)-N-(1-(5-Azaspiro[2.5]octan-5- yl)propan-2-yl)-...)
Affinity DataIC50:  3nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4 [648-1032](Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM243152(D1: N-((R)-1-((abs)-3- (Difluoromethoxy)piperidin-...)
Affinity DataIC50:  3nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM228164(US10047073, 6 | US10047073, 7)
Affinity DataIC50:  3nMAssay Description:The Class I HDAC activity of Class IIa Histone Deacetylase (HDAC) inhibitors was quantified by measuring the cellular histone deacetylase enzymatic a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4 [648-1032](Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM243193(D1: N-((R)-1-((abs-1,5-cis)-6- Azabicyclo[3.2.0]he...)
Affinity DataIC50:  4nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4 [648-1032](Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM243192(N-((2R)-1-(3-Azabicyclo[3.2.0]heptan- 3-yl)propan-...)
Affinity DataIC50:  4nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4 [648-1032](Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM243189((R)-N-(1-(3,4-dihydro-2,7-naphthyridin- 2(1H)-yl)p...)
Affinity DataIC50:  6nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4 [648-1032](Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM243183(N-((R)-1-(3-Azabicyclo[3.2.1]octan-3- yl)propan-2-...)
Affinity DataIC50:  7nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4 [648-1032](Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM243091(N-((2R)-1-(3-Azabicyclo[3.1.0]hexan-3- yl)propan-2...)
Affinity DataIC50:  8nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM228164(US10047073, 6 | US10047073, 7)
Affinity DataIC50:  8nMAssay Description:The Class I HDAC activity of Class IIa Histone Deacetylase (HDAC) inhibitors was quantified by measuring the cellular histone deacetylase enzymatic a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4 [648-1032](Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM243180((R)-N-(1-(5-Azaspiro[2.4]heptan-5- yl)propan-2-yl)...)
Affinity DataIC50:  8nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4 [648-1032](Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM243202((2S)-1-((R)-2-(3-Fluoro-4-(5- (trifluoromethyl)-1,...)
Affinity DataIC50:  9nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4 [648-1032](Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM243121((R)-N-(1-(3,4-Dihydroisoquinolin- 2(1H)-yl)propan-...)
Affinity DataIC50:  9nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM293916((S)-1-(3,4-Difluoro-2- methylphenyl)-N- hydroxy-3-...)
Affinity DataIC50:  10nMAssay Description:2 μl (200×) of each diluted solution and each control (full activity: 100% DMSO alone or full inhibition 1 mM) is stamped into V-bottomed polypr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM293914((S)-3-(Benzo[d]thiazol-5- yl)-1-(3-fluoro-2- methy...)
Affinity DataIC50:  10nMAssay Description:2 μl (200×) of each diluted solution and each control (full activity: 100% DMSO alone or full inhibition 1 mM) is stamped into V-bottomed polypr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM293912((S)-1-(3-Fluoro-2- methylphenyl)-N- hydroxy-3-(1-m...)
Affinity DataIC50:  10nMAssay Description:2 μl (200×) of each diluted solution and each control (full activity: 100% DMSO alone or full inhibition 1 mM) is stamped into V-bottomed polypr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM293911((S)-1-(3-Fluoro-2- methylphenyl)-N- hydroxy-3-(2- ...)
Affinity DataIC50:  10nMAssay Description:2 μl (200×) of each diluted solution and each control (full activity: 100% DMSO alone or full inhibition 1 mM) is stamped into V-bottomed polypr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM293900((S)-3-(5-Chloro-6- methylpyridin-3-yl)-1-(3- fluor...)
Affinity DataIC50:  10nMAssay Description:2 μl (200×) of each diluted solution and each control (full activity: 100% DMSO alone or full inhibition 1 mM) is stamped into V-bottomed polypr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM293899((S)-1-(3-Fluoro-2- methylphenyl)-N- hydroxy-3-(6- ...)
Affinity DataIC50:  10nMAssay Description:2 μl (200×) of each diluted solution and each control (full activity: 100% DMSO alone or full inhibition 1 mM) is stamped into V-bottomed polypr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM293895((S)-1-(3-Fluoro-2- methylphenyl)-N- hydroxy-3-(imi...)
Affinity DataIC50:  10nMAssay Description:2 μl (200×) of each diluted solution and each control (full activity: 100% DMSO alone or full inhibition 1 mM) is stamped into V-bottomed polypr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM293886((S)-1-(3-Fluoro-2- methylphenyl)-N- hydroxy-3-(qui...)
Affinity DataIC50:  10nMAssay Description:2 μl (200×) of each diluted solution and each control (full activity: 100% DMSO alone or full inhibition 1 mM) is stamped into V-bottomed polypr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM293880((S)-1-(3-Fluoro-2- methylphenyl)-3-(5- fluoropyrid...)
Affinity DataIC50:  10nMAssay Description:2 μl (200×) of each diluted solution and each control (full activity: 100% DMSO alone or full inhibition 1 mM) is stamped into V-bottomed polypr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM293916((S)-1-(3,4-Difluoro-2- methylphenyl)-N- hydroxy-3-...)
Affinity DataIC50:  10nMAssay Description:5 μl of each solution of 1:20 diluted compound from above is transferred to a clear bottomed, black, 384-well assay plate using the Bravo or the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM293914((S)-3-(Benzo[d]thiazol-5- yl)-1-(3-fluoro-2- methy...)
Affinity DataIC50:  10nMAssay Description:5 μl of each solution of 1:20 diluted compound from above is transferred to a clear bottomed, black, 384-well assay plate using the Bravo or the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM293912((S)-1-(3-Fluoro-2- methylphenyl)-N- hydroxy-3-(1-m...)
Affinity DataIC50:  10nMAssay Description:5 μl of each solution of 1:20 diluted compound from above is transferred to a clear bottomed, black, 384-well assay plate using the Bravo or the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM293911((S)-1-(3-Fluoro-2- methylphenyl)-N- hydroxy-3-(2- ...)
Affinity DataIC50:  10nMAssay Description:5 μl of each solution of 1:20 diluted compound from above is transferred to a clear bottomed, black, 384-well assay plate using the Bravo or the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM293900((S)-3-(5-Chloro-6- methylpyridin-3-yl)-1-(3- fluor...)
Affinity DataIC50:  10nMAssay Description:5 μl of each solution of 1:20 diluted compound from above is transferred to a clear bottomed, black, 384-well assay plate using the Bravo or the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM293899((S)-1-(3-Fluoro-2- methylphenyl)-N- hydroxy-3-(6- ...)
Affinity DataIC50:  10nMAssay Description:5 μl of each solution of 1:20 diluted compound from above is transferred to a clear bottomed, black, 384-well assay plate using the Bravo or the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM293895((S)-1-(3-Fluoro-2- methylphenyl)-N- hydroxy-3-(imi...)
Affinity DataIC50:  10nMAssay Description:5 μl of each solution of 1:20 diluted compound from above is transferred to a clear bottomed, black, 384-well assay plate using the Bravo or the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM293886((S)-1-(3-Fluoro-2- methylphenyl)-N- hydroxy-3-(qui...)
Affinity DataIC50:  10nMAssay Description:5 μl of each solution of 1:20 diluted compound from above is transferred to a clear bottomed, black, 384-well assay plate using the Bravo or the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM293880((S)-1-(3-Fluoro-2- methylphenyl)-3-(5- fluoropyrid...)
Affinity DataIC50:  10nMAssay Description:5 μl of each solution of 1:20 diluted compound from above is transferred to a clear bottomed, black, 384-well assay plate using the Bravo or the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4 [648-1032](Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM243178((R)-N-(1-(Azepan-1-yl)propan-2-yl)-4- (5-(trifluor...)
Affinity DataIC50:  11nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 9(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM272075((S)-1-(2,6-Difluorophenyl)-5-(3-fluoro-2- methylph...)
Affinity DataIC50:  12nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4 [648-1032](Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM243187(2-((R)-2-(4-(5-(Trifluoromethyl)-1,2,4- oxadiazol-...)
Affinity DataIC50:  12nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 9(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM272075((S)-1-(2,6-Difluorophenyl)-5-(3-fluoro-2- methylph...)
Affinity DataIC50:  12nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4 [648-1032](Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM243123((R)-N-(1-(3-Phenylazetidin-1-yl)propan- 2-yl)-4-(5...)
Affinity DataIC50:  14nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 9(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM272071((S)-1-(2-Chlorophenyl)-5-(3-fluoro-2-methylphenyl)...)
Affinity DataIC50:  15nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 9(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM272078((S)-1-(2-Chloro-6-fluorophenyl)-5-(3-fluoro-2- met...)
Affinity DataIC50:  15nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 9(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM272078((S)-1-(2-Chloro-6-fluorophenyl)-5-(3-fluoro-2- met...)
Affinity DataIC50:  15nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 9(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM272071((S)-1-(2-Chlorophenyl)-5-(3-fluoro-2-methylphenyl)...)
Affinity DataIC50:  15nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4 [648-1032](Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM243179((R)-N-(1-(1-Azaspiro[3.3]heptan-1- yl)propan-2-yl)...)
Affinity DataIC50:  16nMAssay Description:5 μL of each solution of 1:20 diluted compound from above was transferred to a clear bottomed, black, 384-well assay plate using the Bravo or th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 9(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM272074((S)-1-(3-Chloro-2-fluorophenyl)-5-(3-fluoro-2- met...)
Affinity DataIC50:  17nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 9(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM272067((S)-5-(3-Fluoro-2-methylphenyl)-l-(2-fluorophenyl)...)
Affinity DataIC50:  17nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 9(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM272067((S)-5-(3-Fluoro-2-methylphenyl)-l-(2-fluorophenyl)...)
Affinity DataIC50:  17nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 9(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM272074((S)-1-(3-Chloro-2-fluorophenyl)-5-(3-fluoro-2- met...)
Affinity DataIC50:  17nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM448369(Perampanel, 21)
Affinity DataIC50:  18nMAssay Description:Inhibition of proteolytic activity was tested using recombinant SARS-CoV-2Mpro, which was expressed and purified as previously described.8,12 For the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
TargetHistone deacetylase 9(Homo sapiens (Human))
Chdi Foundation

US Patent
LigandPNGBDBM272079((S)-5-(3-Fluoro-2-methylphenyl)-1-(2-fluoro-6- met...)
Affinity DataIC50:  19nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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