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Found 140 with Last Name = 'sun' and Initial = 'jr'
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340122(CHEMBL1760036 | N4-(naphthalen-2-yl)-N2-(3,4,5-tri...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340126(CHEMBL1738698 | N2-(3-methoxy-4-morpholinophenyl)-...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)
Affinity DataIC50:  3nMAssay Description:Inhibition of INSRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340128(CHEMBL1760041 | N4-(quinolin-6-yl)-N2-(3,4,5-trime...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340144(CHEMBL1760058 | N2-(3-methoxy-4-(3-(piperidin-1-yl...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340127(CHEMBL1760040 | N4-(isoquinolin-3-yl)-N2-(3,4,5-tr...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340126(CHEMBL1738698 | N2-(3-methoxy-4-morpholinophenyl)-...)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326206(CHEMBL1243200 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50:  9nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340120(CHEMBL1760034 | N2-(naphthalen-2-yl)-N4-(3,4,5-tri...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340127(CHEMBL1760040 | N4-(isoquinolin-3-yl)-N2-(3,4,5-tr...)
Affinity DataIC50:  14nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326208(4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimid...)
Affinity DataIC50:  15nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326204(CHEMBL1243137 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50:  17nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340135(CHEMBL1760049 | N2-(3,4-dimethoxyphenyl)-N4-(quino...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)
Affinity DataIC50:  19nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340143(CHEMBL1760057 | N2-(4-(3-(piperidin-1-yl)propoxy)p...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340136(CHEMBL1760050 | N2-(3,5-dimethoxyphenyl)-N4-(quino...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340142(CHEMBL1760056 | N2-(4-morpholinophenyl)-N4-(quinol...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326207(CHEMBL1243294 | N-(4-(3-(2-(Methylamino)pyrimidin-...)
Affinity DataIC50:  22nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340143(CHEMBL1760057 | N2-(4-(3-(piperidin-1-yl)propoxy)p...)
Affinity DataIC50:  24nMAssay Description:Inhibition of INSRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340118(CHEMBL1760048 | N4-(3-(trifluoromethoxy)phenyl)-N2...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340131(CHEMBL1760044 | N4-(1H-indazol-5-yl)-N2-(3,4,5-tri...)
Affinity DataIC50:  34nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340141(CHEMBL1760055 | N2-(3-chloro-4-methoxyphenyl)-N4-(...)
Affinity DataIC50:  36nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340144(CHEMBL1760058 | N2-(3-methoxy-4-(3-(piperidin-1-yl...)
Affinity DataIC50:  36nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340128(CHEMBL1760041 | N4-(quinolin-6-yl)-N2-(3,4,5-trime...)
Affinity DataIC50:  37nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340138(CHEMBL1760052 | N2-(3-methoxyphenyl)-N4-(quinolin-...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340119(CHEMBL1760033 | N2-(quinolin-3-yl)-N4-(3,4,5-trime...)
Affinity DataIC50:  41nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340140(CHEMBL1760054 | N2-(3-chlorophenyl)-N4-(quinolin-3...)
Affinity DataIC50:  41nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340123(CHEMBL1760037 | N4-(2-methylquinolin-3-yl)-N2-(3,4...)
Affinity DataIC50:  48nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340137(CHEMBL1760051 | N2-(4-methoxyphenyl)-N4-(quinolin-...)
Affinity DataIC50:  55nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326202(CHEMBL1243042 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50:  56nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340129(CHEMBL1760042 | N4-(quinoxalin-6-yl)-N2-(3,4,5-tri...)
Affinity DataIC50:  58nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50:  66nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340143(CHEMBL1760057 | N2-(4-(3-(piperidin-1-yl)propoxy)p...)
Affinity DataIC50:  81nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340122(CHEMBL1760036 | N4-(naphthalen-2-yl)-N2-(3,4,5-tri...)
Affinity DataIC50:  88nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(CHEMBL1760035 | N4-(quinolin-3-yl)-N2-(3,4,5-trime...)
Affinity DataIC50:  94nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340130(CHEMBL1760043 | N4-(1H-indazol-6-yl)-N2-(3,4,5-tri...)
Affinity DataIC50:  103nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326205(CHEMBL1243167 | N-(2-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50:  110nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340133(CHEMBL1760046 | N4-(3,3-dimethylindolin-6-yl)-N2-(...)
Affinity DataIC50:  123nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340119(CHEMBL1760033 | N2-(quinolin-3-yl)-N4-(3,4,5-trime...)
Affinity DataIC50:  175nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340142(CHEMBL1760056 | N2-(4-morpholinophenyl)-N4-(quinol...)
Affinity DataIC50:  177nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340139(CHEMBL1760053 | N4-(quinolin-3-yl)-N2-(3-(trifluor...)
Affinity DataIC50:  198nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340132(CHEMBL1760045 | N4-(1H-benzo[d]imidazol-6-yl)-N2-(...)
Affinity DataIC50:  201nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340134(CHEMBL1760047 | N4-(pyridin-2-yl)-N2-(3,4,5-trimet...)
Affinity DataIC50:  251nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326203(CHEMBL1243073 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50:  251nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326201(4-Chloro-N-(3-methyl-4-(3-(2-(methylamino)pyrimidi...)
Affinity DataIC50:  335nMAssay Description:Inhibition of Aurora B by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340141(CHEMBL1760055 | N2-(3-chloro-4-methoxyphenyl)-N4-(...)
Affinity DataIC50:  356nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326198(CHEMBL1242977 | N-(3-Methyl-4-(3-(2-(methylamino)p...)
Affinity DataIC50:  385nMAssay Description:Inhibition of LCK by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340120(CHEMBL1760034 | N2-(naphthalen-2-yl)-N4-(3,4,5-tri...)
Affinity DataIC50:  409nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340123(CHEMBL1760037 | N4-(2-methylquinolin-3-yl)-N2-(3,4...)
Affinity DataIC50:  420nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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