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Found 298 with Last Name = 'suto' and Initial = 'mj'
TargetThrombospondin-1(Homo sapiens)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50541838(CHEMBL4649483)
Affinity DataIC50:  0.380nMAssay Description:Inhibition of TSP1 in human myeloma cells assessed reduction in TGFbeta activity incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetThrombospondin-1(Homo sapiens)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50541831(CHEMBL4644535)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of TSP1 in human myeloma cells assessed reduction in TGFbeta activity incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetThrombospondin-1(Homo sapiens)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50541837(CHEMBL4642848)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of TSP1 in human myeloma cells assessed reduction in TGFbeta activity incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThrombospondin-1(Homo sapiens)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50541836(CHEMBL4642780)
Affinity DataIC50:  2nMAssay Description:Inhibition of TSP1 in human myeloma cells assessed reduction in TGFbeta activity incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThrombospondin-1(Homo sapiens)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50541828(CHEMBL4633877)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of TSP1 in human myeloma cells assessed reduction in TGFbeta activity incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThrombospondin-1(Homo sapiens)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50541833(CHEMBL4636492)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of TSP1 in human myeloma cells assessed reduction in TGFbeta activity incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThrombospondin-1(Homo sapiens)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50541832(CHEMBL4648099)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of TSP1 in human myeloma cells assessed reduction in TGFbeta activity incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThrombospondin-1(Homo sapiens)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50541830(CHEMBL4647669)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of TSP1 in human myeloma cells assessed reduction in TGFbeta activity incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetThrombospondin-1(Homo sapiens)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50541826(CHEMBL4644244)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of TSP1 in human myeloma cells assessed reduction in TGFbeta activity incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThrombospondin-1(Homo sapiens)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50541839(CHEMBL4649293)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of TSP1 in human myeloma cells assessed reduction in TGFbeta activity incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Southern Research

Curated by ChEMBL
LigandPNGBDBM50365262((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...)
Affinity DataIC50:  9nMAssay Description:Displacement of biotinylated acetylated histone H4 peptide from human recombinant N-terminal GST-tagged BRD4 BD1 (49 to 170 residues) expressed in Es...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetThrombospondin-1(Homo sapiens)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50541827(CHEMBL4644046)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of TSP1 in human myeloma cells assessed reduction in TGFbeta activity incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThrombospondin-1(Homo sapiens)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50541834(CHEMBL4644197)
Affinity DataIC50:  13nMAssay Description:Inhibition of TSP1 in human myeloma cells assessed reduction in TGFbeta activity incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThrombospondin-1(Homo sapiens)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50541835(CHEMBL4645518)
Affinity DataIC50:  14nMAssay Description:Inhibition of TSP1 in human myeloma cells assessed reduction in TGFbeta activity incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThrombospondin-1(Homo sapiens)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50541829(CHEMBL4638959)
Affinity DataIC50:  15nMAssay Description:Inhibition of TSP1 in human myeloma cells assessed reduction in TGFbeta activity incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Southern Research

Curated by ChEMBL
LigandPNGBDBM15339(6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-qui...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant full length C-terminal MYC/DDk-tagged DHODH using decylubiquinone as substrate measured for 1 hr by DCIP absorbance a...More data for this Ligand-Target Pair
TargetTranscription factor Jun(Homo sapiens (Human))
Signal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50092879(2-Chloro-4-methyl-pyrimidine-5-carboxylic acid (3,...)
Affinity DataIC50:  20nMAssay Description:Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Southern Research

Curated by ChEMBL
LigandPNGBDBM50399434(CHEMBL2179387)
Affinity DataIC50:  41nMAssay Description:Displacement of biotinylated acetylated histone H4 peptide from human recombinant N-terminal GST-tagged BRD4 BD1 (49 to 170 residues) expressed in Es...More data for this Ligand-Target Pair
TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
Signal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062648(2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Affinity DataIC50:  50nMAssay Description:In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic AMP-dependent transcription factor ATF-1(Homo sapiens (Human))
Signal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062648(2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Affinity DataIC50:  50nMAssay Description:In vitro inhibitory activity against human Jurkat T-Cells stably transfected with activating transcription factor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
Signal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062648(2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Affinity DataIC50:  50nMAssay Description:Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
Signal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50092877(2-Fluoro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Affinity DataIC50:  100nMAssay Description:Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic AMP-dependent transcription factor ATF-1(Homo sapiens (Human))
Signal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062645(3-[(2-Chloro-4-trifluoromethyl-pyrimidine-5-carbon...)
Affinity DataIC50:  120nMAssay Description:In vitro inhibitory activity against human Jurkat T-Cells stably transfected with activating transcription factor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic AMP-dependent transcription factor ATF-1(Homo sapiens (Human))
Signal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062658(3-[(2-Chloro-4-trifluoromethyl-pyrimidine-5-carbon...)
Affinity DataIC50:  150nMAssay Description:In vitro inhibitory activity against human Jurkat T-Cells stably transfected with activating transcription factor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
Signal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062645(3-[(2-Chloro-4-trifluoromethyl-pyrimidine-5-carbon...)
Affinity DataIC50:  170nMAssay Description:In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Southern Research

Curated by ChEMBL
LigandPNGBDBM50600176(CHEMBL5183863)
Affinity DataIC50:  170nMAssay Description:Displacement of biotinylated acetylated histone H4 peptide from human recombinant N-terminal GST-tagged BRD4 BD1 (49 to 170 residues) expressed in Es...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTranscription factor Jun(Homo sapiens (Human))
Signal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50092882(2,4-Dichloro-pyrimidine-5-carboxylic acid (3,5-bis...)
Affinity DataIC50:  200nMAssay Description:Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Southern Research

Curated by ChEMBL
LigandPNGBDBM50399434(CHEMBL2179387)
Affinity DataIC50:  220nMAssay Description:Displacement of acetylated histone H4 peptide from His-tagged recombinant human BRD4 expressed in bacteria by AlphaScreen assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Southern Research

Curated by ChEMBL
LigandPNGBDBM50600183(CHEMBL5180188)
Affinity DataIC50:  220nMAssay Description:Displacement of biotinylated acetylated histone H4 peptide from human recombinant N-terminal GST-tagged BRD4 BD1 (49 to 170 residues) expressed in Es...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
Signal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062658(3-[(2-Chloro-4-trifluoromethyl-pyrimidine-5-carbon...)
Affinity DataIC50:  280nMAssay Description:In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
Signal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50092872(2-Chloro-4-ethyl-pyrimidine-5-carboxylic acid (3,5...)
Affinity DataIC50:  300nMAssay Description:Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
Signal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50092890(2-Chloro-pyrimidine-5-carboxylic acid (3,5-bis-tri...)
Affinity DataIC50:  300nMAssay Description:Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Southern Research

Curated by ChEMBL
LigandPNGBDBM50576030(CHEMBL4860581)
Affinity DataIC50:  310nMAssay Description:Inhibition of human recombinant full length C-terminal MYC/DDk-tagged DHODH using decylubiquinone as substrate measured for 1 hr by DCIP absorbance a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Southern Research

Curated by ChEMBL
LigandPNGBDBM50600184(CHEMBL5182381)
Affinity DataIC50:  330nMAssay Description:Displacement of biotinylated acetylated histone H4 peptide from human recombinant N-terminal GST-tagged BRD4 BD1 (49 to 170 residues) expressed in Es...More data for this Ligand-Target Pair
TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
Signal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062669(2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Affinity DataIC50:  380nMAssay Description:In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Southern Research

Curated by ChEMBL
LigandPNGBDBM50600177(CHEMBL5197705)
Affinity DataIC50:  380nMAssay Description:Displacement of biotinylated acetylated histone H4 peptide from human recombinant N-terminal GST-tagged BRD4 BD1 (49 to 170 residues) expressed in Es...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Southern Research

Curated by ChEMBL
LigandPNGBDBM50600178(CHEMBL5207755)
Affinity DataIC50:  380nMAssay Description:Displacement of biotinylated acetylated histone H4 peptide from human recombinant N-terminal GST-tagged BRD4 BD1 (49 to 170 residues) expressed in Es...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTranscription factor Jun(Homo sapiens (Human))
Signal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50092883(2-Chloro-4-phenyl-pyrimidine-5-carboxylic acid (3,...)
Affinity DataIC50:  400nMAssay Description:Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Southern Research

Curated by ChEMBL
LigandPNGBDBM50600185(CHEMBL5173109)
Affinity DataIC50:  440nMAssay Description:Displacement of biotinylated acetylated histone H4 peptide from human recombinant N-terminal GST-tagged BRD4 BD1 (49 to 170 residues) expressed in Es...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCyclic AMP-dependent transcription factor ATF-1(Homo sapiens (Human))
Signal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062669(2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Affinity DataIC50:  490nMAssay Description:In vitro inhibitory activity against human Jurkat T-Cells stably transfected with activating transcription factor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
Signal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062661(2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Affinity DataIC50:  500nMAssay Description:In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic AMP-dependent transcription factor ATF-1(Homo sapiens (Human))
Signal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062661(2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Affinity DataIC50:  500nMAssay Description:In vitro inhibitory activity against human Jurkat T-Cells stably transfected with activating transcription factor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic AMP-dependent transcription factor ATF-1(Homo sapiens (Human))
Signal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062663(2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Affinity DataIC50:  500nMAssay Description:In vitro inhibitory activity against human Jurkat T-Cells stably transfected with activating transcription factor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
Signal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50092871(2-Chloro-4-propyl-pyrimidine-5-carboxylic acid (3,...)
Affinity DataIC50:  500nMAssay Description:Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Southern Research

Curated by ChEMBL
LigandPNGBDBM50600194(CHEMBL5187326)
Affinity DataIC50:  600nMAssay Description:Displacement of biotinylated acetylated histone H4 peptide from human recombinant N-terminal GST-tagged BRD4 BD1 (49 to 170 residues) expressed in Es...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTranscription factor Jun(Homo sapiens (Human))
Signal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50092880(2-Chloro-4-pentafluoroethyl-pyrimidine-5-carboxyli...)
Affinity DataIC50:  600nMAssay Description:Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
Signal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062653(3-[(2-Chloro-4-trifluoromethyl-pyrimidine-5-carbon...)
Affinity DataIC50:  620nMAssay Description:In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic AMP-dependent transcription factor ATF-1(Homo sapiens (Human))
Signal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062653(3-[(2-Chloro-4-trifluoromethyl-pyrimidine-5-carbon...)
Affinity DataIC50:  660nMAssay Description:In vitro inhibitory activity against human Jurkat T-Cells stably transfected with activating transcription factor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50230839(CHEMBL15087)
Affinity DataIC50:  754nMAssay Description:Inhibition against DNA gyraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
Signal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50062663(2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic...)
Affinity DataIC50:  800nMAssay Description:In vitro inhibitory activity against human Jurkat T-Cells stably transfected with an Nuclear factor kappa B transcription factorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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