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Found 490 with Last Name = 'takahashi' and Initial = 'n'
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  0.440nMAssay Description:Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290098((R)-3-Cyclohexylmethyl-1,8,8-trimethyl-3-aza-bicyc...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290099((S)-3-(4-Cyclohexyl-butyl)-1,8,8-trimethyl-3-aza-b...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290100((S)-3-Cyclohexylmethyl-1,8,8-trimethyl-3-aza-bicyc...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290095((R)-3-(2-Cyclohexyl-ethyl)-1,8,8-trimethyl-3-aza-b...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290096((S)-3-(2-Cyclopentyl-ethyl)-1,8,8-trimethyl-3-aza-...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290094((S)-3-(2-Cyclohexyl-ethyl)-1,8,8-trimethyl-3-aza-b...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290101((S)-3-(3-Cyclohexyl-propyl)-1,8,8-trimethyl-3-aza-...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290093((S)-3-(2-Cyclooctyl-ethyl)-1,8,8-trimethyl-3-aza-b...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290092((S)-3-(2-Cycloheptyl-ethyl)-1,8,8-trimethyl-3-aza-...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290097((S)-3-Cyclohexyl-1,8,8-trimethyl-3-aza-bicyclo[3.2...)
Affinity DataKi:  3nMAssay Description:Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290091((S)-3-(2-Adamantan-2-yl-ethyl)-1,8,8-trimethyl-3-a...)
Affinity DataKi:  4.30nMAssay Description:Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM81982(CAS_97-39-2 | DITOLYLGUANIDINE | DTG | Di-o-tolylg...)
Affinity DataKi:  27nMAssay Description:Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50001044((1S,9S,13S)-10-allyl-1,13-dimethyl-10-azatricyclo[...)
Affinity DataKi:  157nMAssay Description:Inhibition of [3H]-pentazocine binding to Sigma opioid receptor type 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162144(1-(4-Chloro-phenyl)-3-[4-(6,7-dimethoxy-quinolin-4...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162154(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(2...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162167(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-ph...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162143(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-m-...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Kyoto 607-8042

Curated by ChEMBL
LigandPNGBDBM50042053(CHEMBL3360172)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of PDE7A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162168(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(4...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162169(1-(2,5-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162166(1-[2-Chloro-4-(6,7-dimethoxy-quinolin-4-yloxy)-phe...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162155(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-p-...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162142(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(2...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Kyoto 607-8042

Curated by ChEMBL
LigandPNGBDBM50042036(CHEMBL3360170)
Affinity DataIC50:  0.680nMAssay Description:Inhibition of PDE7A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162156(1-(2,3-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162148(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162147(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2 in cell-intact assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Kyoto 607-8042

Curated by ChEMBL
LigandPNGBDBM50032547(CHEMBL3354181)
Affinity DataIC50:  1nMAssay Description:Inhibition of human PDE7A1 expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162160(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Affinity DataIC50: <1nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162145(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(3...)
Affinity DataIC50: <1nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Kyoto 607-8042

Curated by ChEMBL
LigandPNGBDBM50042037(CHEMBL3360169)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of PDE7A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162158(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(3...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162140(1-(3,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162152(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(4...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Kyoto 607-8042

Curated by ChEMBL
LigandPNGBDBM50042035(CHEMBL3360171)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of PDE7A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162162(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(3...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Kyoto 607-8042

Curated by ChEMBL
LigandPNGBDBM50068286(CHEMBL3403373)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Kyoto 607-8042

Curated by ChEMBL
LigandPNGBDBM50068283(CHEMBL3403371)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human PDE7A expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162171(1-(3-Chloro-phenyl)-3-[4-(6,7-dimethoxy-quinolin-4...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162156(1-(2,3-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of platelet-derived growth factor receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162170(1-(2,6-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162163(1-(3,5-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Kyoto 607-8042

Curated by ChEMBL
LigandPNGBDBM50032540(CHEMBL3354179)
Affinity DataIC50:  2nMAssay Description:Inhibition of PDE7A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162145(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(3...)
Affinity DataIC50:  2nMAssay Description:Inhibition of platelet-derived growth factor receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Kyoto 607-8042

Curated by ChEMBL
LigandPNGBDBM50032540(CHEMBL3354179)
Affinity DataIC50:  2nMAssay Description:Inhibition of human PDE7A1 expressed in insect cells assessed as inhibition of [3H]cAMP to [3H]AMP hydrolysis after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162152(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(4...)
Affinity DataIC50:  2nMAssay Description:Inhibition of platelet-derived growth factor receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Kyoto 607-8042

Curated by ChEMBL
LigandPNGBDBM50042039(CHEMBL3360167)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of PDE7A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162157(1-[4-(6,7-Dimethoxy-quinazolin-4-yloxy)-phenyl]-3-...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50162150(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-o-...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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