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Found 47 with Last Name = 'tallapragada' and Initial = 'k'
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Targacept

Curated by ChEMBL
LigandPNGBDBM50356471(CHEMBL1911861)
Affinity DataKi:  7.20nMAssay Description:Displacement of [3H]-methyllycaconitine from alpha7 nAChR in rat hippocampal membranes after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50264117(3-[1-(4-Hydroxy-2-methoxy-phenyl)-meth-(E)-ylidene...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAchR expressed in SH-EP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Targacept

Curated by ChEMBL
LigandPNGBDBM50356467(CHEMBL1911855)
Affinity DataKi:  42nMAssay Description:Displacement of [3H]-methyllycaconitine from alpha7 nAChR in rat hippocampal membranes after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50061564((3E)-3-[(2,4-DIMETHOXYPHENYL)METHYLIDENE]-3,4,5,6-...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAchR expressed in SH-EP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Targacept

Curated by ChEMBL
LigandPNGBDBM50356469(CHEMBL1911857)
Affinity DataKi:  58nMAssay Description:Displacement of [3H]-methyllycaconitine from alpha7 nAChR in rat hippocampal membranes after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Targacept

Curated by ChEMBL
LigandPNGBDBM50356468(CHEMBL1911856)
Affinity DataKi:  77nMAssay Description:Displacement of [3H]-methyllycaconitine from alpha7 nAChR in rat hippocampal membranes after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Targacept

Curated by ChEMBL
LigandPNGBDBM50356466(CHEMBL1911854)
Affinity DataKi:  87nMAssay Description:Displacement of [3H]-methyllycaconitine from alpha7 nAChR in rat hippocampal membranes after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Targacept

Curated by ChEMBL
LigandPNGBDBM50356465(CHEMBL1911853)
Affinity DataKi:  110nMAssay Description:Displacement of [3H]-methyllycaconitine from alpha7 nAChR in rat hippocampal membranes after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Targacept

Curated by ChEMBL
LigandPNGBDBM50356472(CHEMBL1911862)
Affinity DataKi:  120nMAssay Description:Displacement of [3H]-methyllycaconitine from alpha7 nAChR in rat hippocampal membranes after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Targacept

Curated by ChEMBL
LigandPNGBDBM50356464(CHEMBL1911852)
Affinity DataKi:  140nMAssay Description:Displacement of [3H]-methyllycaconitine from alpha7 nAChR in rat hippocampal membranes after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Targacept

Curated by ChEMBL
LigandPNGBDBM50356470(CHEMBL1911858)
Affinity DataKi:  150nMAssay Description:Displacement of [3H]-methyllycaconitine from alpha7 nAChR in rat hippocampal membranes after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Targacept

Curated by ChEMBL
LigandPNGBDBM50356473(CHEMBL1911864)
Affinity DataKi:  290nMAssay Description:Displacement of [3H]-methyllycaconitine from alpha7 nAChR in rat hippocampal membranes after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Targacept

Curated by ChEMBL
LigandPNGBDBM50264117(3-[1-(4-Hydroxy-2-methoxy-phenyl)-meth-(E)-ylidene...)
Affinity DataKi:  420nMAssay Description:Displacement of [3H]-methyllycaconitine from alpha7 nAChR in rat hippocampal membranes after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Targacept

Curated by ChEMBL
LigandPNGBDBM50061564((3E)-3-[(2,4-DIMETHOXYPHENYL)METHYLIDENE]-3,4,5,6-...)
Affinity DataKi:  1.30E+3nMAssay Description:Displacement of [3H]-methyllycaconitine from alpha7 nAChR in rat hippocampal membranes after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50490640(3-Benzhydrylquinuclidine | CHEMBL2332279)
Affinity DataKi:  1.50E+3nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in CHO cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50397943(CHEMBL2179959)
Affinity DataKi:  1.60E+3nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in CHO cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50270282((E/Z)-3-benzylidenequinuclidine | CHEMBL478358)
Affinity DataKi:  2.10E+3nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in CHO cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50490641(CHEMBL2332277)
Affinity DataKi:  2.10E+3nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in CHO cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50441363(CHEMBL2332280)
Affinity DataKi:  2.20E+3nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in CHO cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50490639(CHEMBL2332278)
Affinity DataKi:  2.30E+3nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in CHO cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50441360(CHEMBL2332276)
Affinity DataKi:  8.50E+3nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in CHO cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Targacept

Curated by ChEMBL
LigandPNGBDBM50441363(CHEMBL2332280)
Affinity DataIC50:  76nMAssay Description:Antagonist activity at rat muscarinic M1 receptor isolated from brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50490639(CHEMBL2332278)
Affinity DataIC50:  80nMAssay Description:Inhibition of human alpha3beta4 nAChR expressed in CHO cells assessed as inhibition of calcium influx by calcium-4 based FLIPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50441363(CHEMBL2332280)
Affinity DataIC50:  100nMAssay Description:Inhibition of human alpha3beta4 nAChR expressed in CHO cells assessed as inhibition of calcium influx by calcium-4 based FLIPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50490640(3-Benzhydrylquinuclidine | CHEMBL2332279)
Affinity DataIC50:  200nMAssay Description:Inhibition of human alpha3beta4 nAChR expressed in CHO cells assessed as inhibition of calcium influx by calcium-4 based FLIPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Targacept

Curated by ChEMBL
LigandPNGBDBM50441363(CHEMBL2332280)
Affinity DataIC50:  372nMAssay Description:Antagonist activity at rat muscarinic M2 receptor isolated from brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50441363(CHEMBL2332280)
Affinity DataIC50:  380nMAssay Description:Non-competitive antagonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as inhibition of nicotine-induced calcium influx incub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50441363(CHEMBL2332280)
Affinity DataIC50:  380nMAssay Description:Non-competitive antagonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as inhibition of nicotine-induced calcium influx incub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50490640(3-Benzhydrylquinuclidine | CHEMBL2332279)
Affinity DataIC50:  398nMAssay Description:Non-competitive antagonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as inhibition of nicotine-induced calcium influx incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50490640(3-Benzhydrylquinuclidine | CHEMBL2332279)
Affinity DataIC50:  400nMAssay Description:Non-competitive antagonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as inhibition of nicotine-induced calcium influx incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50490639(CHEMBL2332278)
Affinity DataIC50:  600nMAssay Description:Non-competitive antagonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as inhibition of nicotine-induced calcium influx incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50490639(CHEMBL2332278)
Affinity DataIC50:  603nMAssay Description:Non-competitive antagonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as inhibition of nicotine-induced calcium influx incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50270282((E/Z)-3-benzylidenequinuclidine | CHEMBL478358)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of human alpha3beta4 nAChR expressed in CHO cells assessed as inhibition of calcium influx by calcium-4 based FLIPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50397943(CHEMBL2179959)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human alpha3beta4 nAChR expressed in CHO cells assessed as inhibition of calcium influx by calcium-4 based FLIPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50441360(CHEMBL2332276)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of human alpha3beta4 nAChR expressed in CHO cells assessed as inhibition of calcium influx by calcium-4 based FLIPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50490641(CHEMBL2332277)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of human alpha3beta4 nAChR expressed in CHO cells assessed as inhibition of calcium influx by calcium-4 based FLIPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50397943(CHEMBL2179959)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as calcium influx by calcium-4 based FLIPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50270282((E/Z)-3-benzylidenequinuclidine | CHEMBL478358)
Affinity DataEC50:  3.00E+3nMAssay Description:Agonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as calcium influx by calcium-4 based FLIPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Targacept

Curated by ChEMBL
LigandPNGBDBM50356472(CHEMBL1911862)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at rat recombinant alpha7 nAChR expressed in GH4C1 cells by patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50490639(CHEMBL2332278)
Affinity DataEC50:  9.00E+3nMAssay Description:Agonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as calcium influx by calcium-4 based FLIPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholine-binding protein(Lymnaea stagnalis)
Targacept

Curated by ChEMBL
LigandPNGBDBM50320567(3-(2,4-Dihydroxybenzylidene)anabaseine | CHEMBL116...)
Affinity DataKd:  0.800nMAssay Description:Displacement of [3H]-epibatidine from Lymnaea stagnalis N-terminal FLAG-tagged AChBP expressed in HEK293 cells after 2 hrs by liquid scintillation co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50441363(CHEMBL2332280)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as calcium influx by calcium-4 based FLIPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50490640(3-Benzhydrylquinuclidine | CHEMBL2332279)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as calcium influx by calcium-4 based FLIPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholine-binding protein(Lymnaea stagnalis)
Targacept

Curated by ChEMBL
LigandPNGBDBM50264117(3-[1-(4-Hydroxy-2-methoxy-phenyl)-meth-(E)-ylidene...)
Affinity DataKd:  0.400nMAssay Description:Displacement of [3H]-epibatidine from Lymnaea stagnalis N-terminal FLAG-tagged AChBP expressed in HEK293 cells after 2 hrs by liquid scintillation co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholine-binding protein(Lymnaea stagnalis)
Targacept

Curated by ChEMBL
LigandPNGBDBM50320526(3-(4-Aminobenzylidene)anabaseine | CHEMBL1163383)
Affinity DataKd:  0.800nMAssay Description:Displacement of [3H]-epibatidine from Lymnaea stagnalis N-terminal FLAG-tagged AChBP expressed in HEK293 cells after 2 hrs by liquid scintillation co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Targacept

Curated by ChEMBL
LigandPNGBDBM50264117(3-[1-(4-Hydroxy-2-methoxy-phenyl)-meth-(E)-ylidene...)
Affinity DataEC50:  1.60E+3nMAssay Description:Agonist activity at rat recombinant alpha7 nAChR expressed in GH4C1 cells by patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholine-binding protein(Lymnaea stagnalis)
Targacept

Curated by ChEMBL
LigandPNGBDBM50061564((3E)-3-[(2,4-DIMETHOXYPHENYL)METHYLIDENE]-3,4,5,6-...)
Affinity DataKd:  19nMAssay Description:Displacement of [3H]-epibatidine from Lymnaea stagnalis N-terminal FLAG-tagged AChBP expressed in HEK293 cells after 2 hrs by liquid scintillation co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed