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Found 86 with Last Name = 'tarazi' and Initial = 'm'
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50096629(3-(4-Amino-cyclohexyl)-2-oxo-3-[((6S,8aS)-4-oxo-2-...)
Affinity DataKi:  0.0900nMAssay Description:In vitro activity of the compound against human alpha thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072528((6S,8aS)-2-[3-(3,4-Dichloro-phenyl)-propionyl]-4-o...)
Affinity DataKi:  0.106nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50096623(3-(4-Amino-cyclohexyl)-2-oxo-3-[(4-oxo-2-phenylmet...)
Affinity DataKi:  0.130nMAssay Description:In vitro activity of the compound against human alpha thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50096628(3-(4-Amino-cyclohexyl)-2-oxo-3-[((6S,8aS)-4-oxo-2-...)
Affinity DataKi:  0.260nMAssay Description:In vitro activity of the compound against human alpha thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50096620((6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-p...)
Affinity DataKi:  0.330nMAssay Description:In vitro activity of the compound against human alpha thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072536((6S,8aS)-2-(3-Naphthalen-1-yl-propionyl)-4-oxo-oct...)
Affinity DataKi:  0.350nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072527((6S,8aS)-4-Oxo-2-(3-p-tolyl-propionyl)-octahydro-p...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072534((6S,8aS)-2-(3-Naphthalen-2-yl-propionyl)-4-oxo-oct...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072524((6S,8aS)-4-Oxo-2-[3-(2-trifluoromethyl-phenyl)-pro...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072537((6S,8aS)-2-[3-(4-Methoxy-phenyl)-propionyl]-4-oxo-...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072532((6S,8aS)-4-Oxo-2-(3-phenyl-propionyl)-octahydro-py...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50096621((6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-p...)
Affinity DataKi:  0.720nMAssay Description:In vitro activity of the compound against human alpha thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072520((6S,8aS)-2-[3-(2-Fluoro-phenyl)-propionyl]-4-oxo-o...)
Affinity DataKi:  0.920nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111673((6S,8aS)-2-(Diphenyl-methanesulfonyl)-4-oxo-octahy...)
Affinity DataKi:  1nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111661((6S,8aS)-2-(2,2-Diphenyl-ethanesulfonyl)-4-oxo-oct...)
Affinity DataKi:  1nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072533((6S,8aS)-4-Oxo-2-(4-phenyl-butyryl)-octahydro-pyrr...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111665((6S,8aS)-2-(Diphenyl-methanesulfonyl)-4-oxo-octahy...)
Affinity DataKi:  2nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111658((6S,8aS)-2-(Diphenyl-methanesulfonyl)-4-oxo-octahy...)
Affinity DataKi:  2nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111672((6S,8aS)-2-(Diphenyl-methanesulfonyl)-4-oxo-octahy...)
Affinity DataKi:  2nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111675((6S,8aS)-2-(2,2-Diphenyl-ethanesulfonyl)-4-oxo-oct...)
Affinity DataKi:  2nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50096622(CHEMBL3084834 | {3-(4-Amino-cyclohexyl)-2-oxo-3-[(...)
Affinity DataKi:  2.10nMAssay Description:In vitro activity of the compound against human alpha thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072530((6S,8aS)-4-Oxo-2-phenylacetyl-octahydro-pyrrolo[1,...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072519((6S,8aS)-2-[(S)-2-Amino-3-(4-fluoro-phenyl)-propio...)
Affinity DataKi:  3nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50289562(CHEMBL3216390 | CHEMBL543774 | {(R)-1-Cyclohexylme...)
Affinity DataKi:  3nMAssay Description:Selective inhibition of thrombin in several in vitro and in vivo models of thrombosisMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072541((6S,8aS)-4-Oxo-2-(3-pyridin-2-yl-propionyl)-octahy...)
Affinity DataKi:  3nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50096630((6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-p...)
Affinity DataKi:  3.20nMAssay Description:In vitro activity of the compound against human alpha thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072529((6S,8aS)-2-((S)-2-Hydroxy-3-phenyl-propionyl)-4-ox...)
Affinity DataKi:  4.40nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111671((6S,8aS)-2-(2,2-Diphenyl-ethanesulfonyl)-4-oxo-oct...)
Affinity DataKi:  5nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072535((6S,8aS)-4-Oxo-2-(3-phenoxy-propionyl)-octahydro-p...)
Affinity DataKi:  5nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111676((6S,8aS)-2-(Diphenyl-methanesulfonyl)-4-oxo-octahy...)
Affinity DataKi:  5nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50096627((6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-p...)
Affinity DataKi:  5nMAssay Description:In vitro activity of the compound against human alpha thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111674((6S,8aS)-2-(2,2-Diphenyl-ethanesulfonyl)-4-oxo-oct...)
Affinity DataKi:  8nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111669((6S,8aS)-2-(Diphenyl-methanesulfonyl)-4-oxo-octahy...)
Affinity DataKi:  9nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111663((6S,8aS)-2-(Diphenyl-methanesulfonyl)-4-oxo-octahy...)
Affinity DataKi:  10nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111667((6S,8aS)-4-Oxo-2-(2-phenyl-ethanesulfonyl)-octahyd...)
Affinity DataKi:  14nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50289562(CHEMBL3216390 | CHEMBL543774 | {(R)-1-Cyclohexylme...)
Affinity DataKi:  15nMAssay Description:Inhibition of thrombin was evaulatedMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072521((6S,8aS)-4-Oxo-2-(2-phenoxy-acetyl)-octahydro-pyrr...)
Affinity DataKi:  16nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072538((6S,8aS)-4-Oxo-2-(3-phenyl-propyl)-octahydro-pyrro...)
Affinity DataKi:  17nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072526((6S,8aS)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propi...)
Affinity DataKi:  18nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072526((6S,8aS)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propi...)
Affinity DataKi:  18nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072539((6S,8aS)-2-(3-Cyclohexyl-propionyl)-4-oxo-octahydr...)
Affinity DataKi:  24nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072540((6S,8aS)-2-Benzoyl-4-oxo-octahydro-pyrrolo[1,2-a]p...)
Affinity DataKi:  25nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111668((6S,8aS)-2-(3,3-Diphenyl-propionyl)-4-oxo-octahydr...)
Affinity DataKi:  25nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50096622(CHEMBL3084834 | {3-(4-Amino-cyclohexyl)-2-oxo-3-[(...)
Affinity DataKi:  29nMAssay Description:In vitro activity of the compound against human alpha trypsin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072525((6S,8aS)-4-Oxo-2-(1,2,3,4-tetrahydro-isoquinoline-...)
Affinity DataKi:  32nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111659((6S,8aS)-2-(2,2-Diphenyl-ethanesulfonyl)-4-oxo-oct...)
Affinity DataKi:  35nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50096627((6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-p...)
Affinity DataKi:  35nMAssay Description:In vitro activity of the compound against human alpha trypsin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50289562(CHEMBL3216390 | CHEMBL543774 | {(R)-1-Cyclohexylme...)
Affinity DataKi:  45nMAssay Description:Selective inhibition of thrombin in several in vitro and in vivo models of thrombosisMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111660((6S,8aS)-2-(2,2-Diphenyl-ethanesulfonyl)-4-oxo-oct...)
Affinity DataKi:  48nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072518((6S,8aS)-6-[4-Guanidino-1-(thiazole-2-carbonyl)-bu...)
Affinity DataKi:  50nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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