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Found 86 with Last Name = 'thompson' and Initial = 'dc'
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50019443(1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol ...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity at human adrenergic beta2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50019443(1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol ...)
Affinity DataKi:  0.520nMAssay Description:Binding affinity at human adrenergic beta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136685(CHEMBL337822 | [3-Furan-2-yl-3-(naphthalen-1-yloxy...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)
Affinity DataKi:  0.800nMAssay Description:Ability to inhibit the reuptake of 5-HT at human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136672(CHEMBL342716 | [3-(4-Fluoro-phenyl)-3-(naphthalen-...)
Affinity DataKi:  0.950nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136683(CHEMBL142028 | Methyl-[3-(naphthalen-1-yloxy)-3-th...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220910((S)-1-(1H-indol-4-yloxy)-3-(cyclohexylamino)propan...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136680(CHEMBL424660 | N-methyl-3-(1-naphthyloxy)-3-(2-thi...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136679(CHEMBL141741 | Methyl-[3-(naphthalen-1-yloxy)-3-o-...)
Affinity DataKi:  2nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136689(CHEMBL141114 | Methyl-[3-(naphthalen-1-yloxy)-3-p-...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136690(CHEMBL337791 | [3-(3-Methoxy-phenyl)-3-(naphthalen...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136691(CHEMBL139106 | [3-(2-Methoxy-phenyl)-3-(naphthalen...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136682(CHEMBL141681 | Methyl-[3-(naphthalen-1-yloxy)-3-ph...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220910((S)-1-(1H-indol-4-yloxy)-3-(cyclohexylamino)propan...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity at human adrenergic beta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136686(CHEMBL415244 | [3-(4-Methoxy-phenyl)-3-(naphthalen...)
Affinity DataKi:  3.5nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220914(1-(1H-indol-4-yloxy)-3-(cyclohexylamino)propan-2-o...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136688(CHEMBL139245 | [3-(4-Chloro-phenyl)-3-(naphthalen-...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220910((S)-1-(1H-indol-4-yloxy)-3-(cyclohexylamino)propan...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity at human adrenergic beta2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220911((S)-1-(adamantan-1-ylamino)-3-(1H-indol-4-yloxy)-p...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136675(CHEMBL139277 | Methyl-[3-(naphthalen-1-yloxy)-3-m-...)
Affinity DataKi:  4nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136676(CHEMBL139168 | [3-(4-Bromo-phenyl)-3-(naphthalen-1...)
Affinity DataKi:  4.10nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220911((S)-1-(adamantan-1-ylamino)-3-(1H-indol-4-yloxy)-p...)
Affinity DataKi:  4.70nMAssay Description:Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as inhibition of 5HT-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136670(CHEMBL138031 | Methyl-[3-(naphthalen-1-yloxy)-3-th...)
Affinity DataKi:  6.40nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220911((S)-1-(adamantan-1-ylamino)-3-(1H-indol-4-yloxy)-p...)
Affinity DataKi:  6.60nMAssay Description:Binding affinity at human adrenergic beta2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220910((S)-1-(1H-indol-4-yloxy)-3-(cyclohexylamino)propan...)
Affinity DataKi:  6.70nMAssay Description:Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as inhibition of 5HT-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220912(1-(1H-indol-4-yloxy)-3-(cycloheptylamino)propan-2-...)
Affinity DataKi:  6.80nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)
Affinity DataKi:  7.5nMAssay Description:Ability to inhibit the reuptake of NE at human norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136678(CHEMBL337798 | [3-(3-Bromo-phenyl)-3-(naphthalen-1...)
Affinity DataKi:  7.60nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220917(1-(adamantan-1-ylamino)-3-(1H-indol-4-yloxy)-propa...)
Affinity DataKi:  7.80nMAssay Description:Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as inhibition of 5HT-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220911((S)-1-(adamantan-1-ylamino)-3-(1H-indol-4-yloxy)-p...)
Affinity DataKi:  7.90nMAssay Description:Binding affinity at human adrenergic beta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220917(1-(adamantan-1-ylamino)-3-(1H-indol-4-yloxy)-propa...)
Affinity DataKi:  9.30nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220914(1-(1H-indol-4-yloxy)-3-(cyclohexylamino)propan-2-o...)
Affinity DataKi:  9.80nMAssay Description:Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as inhibition of 5HT-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136677(CHEMBL334929 | Methyl-[3-(naphthalen-1-yloxy)-3-(2...)
Affinity DataKi:  10nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220912(1-(1H-indol-4-yloxy)-3-(cycloheptylamino)propan-2-...)
Affinity DataKi:  11nMAssay Description:Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as inhibition of 5HT-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220922((S)-1-(adamantan-2-ylamino)-3-(1H-indol-4-yloxy)-p...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220918(1-(1H-indol-4-yloxy)-3-(cyclopentylamino)propan-2-...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136673(CHEMBL137936 | Methyl-[3-(naphthalen-1-yloxy)-3-(4...)
Affinity DataKi:  15nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220927((R)-1-(adamantan-1-ylamino)-3-(1H-indol-4-yloxy)-p...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136687(CHEMBL141974 | Methyl-[3-(naphthalen-1-yloxy)-3-(3...)
Affinity DataKi:  19nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136685(CHEMBL337822 | [3-Furan-2-yl-3-(naphthalen-1-yloxy...)
Affinity DataKi:  20nMAssay Description:Inhibition of [3H]-nisoxatine binding to norepinephrine (NE) transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136680(CHEMBL424660 | N-methyl-3-(1-naphthyloxy)-3-(2-thi...)
Affinity DataKi:  20nMAssay Description:Inhibition of [3H]-nisoxatine binding to norepinephrine (NE) transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136682(CHEMBL141681 | Methyl-[3-(naphthalen-1-yloxy)-3-ph...)
Affinity DataKi:  20nMAssay Description:Inhibition of [3H]-nisoxatine binding to norepinephrine (NE) transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136683(CHEMBL142028 | Methyl-[3-(naphthalen-1-yloxy)-3-th...)
Affinity DataKi:  21nMAssay Description:Inhibition of [3H]-nisoxatine binding to norepinephrine (NE) transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50019443(1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol ...)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220922((S)-1-(adamantan-2-ylamino)-3-(1H-indol-4-yloxy)-p...)
Affinity DataKi:  24nMAssay Description:Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as inhibition of 5HT-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220925((R)-1-(1H-indol-4-yloxy)-3-(cyclohexylamino)propan...)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220915(1-(1H-indol-4-yloxy)-3-(pentan-3-ylamino)propan-2-...)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220927((R)-1-(adamantan-1-ylamino)-3-(1H-indol-4-yloxy)-p...)
Affinity DataKi:  30nMAssay Description:Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as inhibition of 5HT-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50136684(CHEMBL138195 | Methyl-[4-(naphthalen-1-yloxy)-buty...)
Affinity DataKi:  31nMAssay Description:Binding affinity to serotonin transporter, using [3H]-citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220930(CHEMBL410364 | adamantan-1-yl-[3-(1H-indol-4-yloxy...)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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