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Found 273 with Last Name = 'tiller' and Initial = 'pr'
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50195169(2,4-dichloro-N-((4-(morpholine-4-carbonyl)-1-(prop...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248651(2,4-dichloro-N-((4-(6-methylpyridin-2-yl)-1-(propy...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human glycine transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248641(2-amino-6-chloro-N-((4-phenyl-1-(propylsulfonyl)pi...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of glycine transporter 1 (unknown origin) by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135934(3-(6-Amino-pyridin-3-yl)-2-[1-(3-methyl-butyl)-1H-...)
Affinity DataIC50:  2.70nMAssay Description:In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248064(2,4-dichloro-N-((4-(2-hydroxycyclohexyl)-1-(propyl...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of Glyt1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248062(2,4-dichloro-N-((1-(propylsulfonyl)-4-((tetrahydro...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of Glyt1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248058((S)-2,4-dichloro-N-(1-(1-(propylsulfonyl)-4-(pyrid...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human glycine transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248669(2-chloro-N-((4-(6-methylpyridin-2-yl)-1-(propylsul...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human glycine transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Merck And

Curated by ChEMBL
LigandPNGBDBM50195169(2,4-dichloro-N-((4-(morpholine-4-carbonyl)-1-(prop...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of rat GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248667(2,4-dichloro-N-((4-(4-methylpyridin-2-yl)-1-(propy...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of human glycine transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248059((S)-2-chloro-3,5-difluoro-N-(1-(1-(propylsulfonyl)...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human glycine transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248100((2,4-dichloro-N-((1-(propylsulfonyl)-4-(pyridin-2-...)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of Glyt1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248100((2,4-dichloro-N-((1-(propylsulfonyl)-4-(pyridin-2-...)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of human glycine transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248648(3,6-dichloro-2-fluoro-N-((1-(propylsulfonyl)-4-(py...)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of human glycine transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135936(3-(6-Amino-pyridin-3-yl)-2-(1-butyl-1H-imidazol-4-...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50195181(2,4-dichloro-5-fluoro-N-((4-(morpholine-4-carbonyl...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of human GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248646(2,6-dichloro-N-((1-(propylsulfonyl)-4-(pyridin-2-y...)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of human glycine transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248647(2-amino-6-chloro-N-((1-(propylsulfonyl)-4-(pyridin...)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of human glycine transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248653(2-chloro-N-((4-(6-methoxypyridin-2-yl)-1-(propylsu...)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of human glycine transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248670(2,4-dichloro-N-((4-(6-methoxypyridin-2-yl)-1-(prop...)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of human glycine transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Merck And

Curated by ChEMBL
LigandPNGBDBM50195181(2,4-dichloro-5-fluoro-N-((4-(morpholine-4-carbonyl...)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of rat GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Mus musculus)
Merck And

Curated by ChEMBL
LigandPNGBDBM50195169(2,4-dichloro-N-((4-(morpholine-4-carbonyl)-1-(prop...)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of mouse GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135939(3-(4,4-Diamino-but-3-enylsulfanyl)-2-mercaptomethy...)
Affinity DataIC50:  8.20nMAssay Description:In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50195166(3-chloro-2,6-difluoro-N-((4-(morpholine-4-carbonyl...)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of human GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248125(2,4-dichloro-N-((1-methyl-1'-(propylsulfonyl)-2,4'...)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of human glycine transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248128(2,4-dichloro-N-((1-(2-fluoropropylsulfonyl)-4-(pyr...)
Affinity DataIC50:  9.70nMAssay Description:Inhibition of Glyt1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50195170(2-chloro-N-((4-(morpholine-4-carbonyl)-1-(propylsu...)
Affinity DataIC50:  9.70nMAssay Description:Inhibition of human GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Merck And

Curated by ChEMBL
LigandPNGBDBM50195173(2-chloro-4-fluoro-N-((4-(morpholine-4-carbonyl)-1-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of rat GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248681(2-chloro-N-((1-(propylsulfonyl)-4-(pyridin-2-yl)pi...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human glycine transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase M(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135939(3-(4,4-Diamino-but-3-enylsulfanyl)-2-mercaptomethy...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of purified Carboxypeptidase M (CPM) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50195173(2-chloro-4-fluoro-N-((4-(morpholine-4-carbonyl)-1-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50195178(2-chloro-6-fluoro-N-((4-(morpholine-4-carbonyl)-1-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248097(2-(4-((2,4-dichlorobenzamido)methyl)-1-(propylsulf...)
Affinity DataIC50:  18nMAssay Description:Inhibition of Glyt1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248013((S)-N-(1-(1-(propylsulfonyl)-4-(pyridin-2-yl)piper...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human glycine transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Merck And

Curated by ChEMBL
LigandPNGBDBM50195170(2-chloro-N-((4-(morpholine-4-carbonyl)-1-(propylsu...)
Affinity DataIC50:  18nMAssay Description:Inhibition of rat GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Mus musculus)
Merck And

Curated by ChEMBL
LigandPNGBDBM50195181(2,4-dichloro-5-fluoro-N-((4-(morpholine-4-carbonyl...)
Affinity DataIC50:  19nMAssay Description:Inhibition of mouse GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248665(CHEMBL517034 | N-((1-(propylsulfonyl)-4-(pyridin-2...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human glycine transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Merck And

Curated by ChEMBL
LigandPNGBDBM50195166(3-chloro-2,6-difluoro-N-((4-(morpholine-4-carbonyl...)
Affinity DataIC50:  20nMAssay Description:Inhibition of rat GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248644(2-methyl-N-((1-(propylsulfonyl)-4-(pyridin-2-yl)pi...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human glycine transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135935(3-(6-Amino-pyridin-3-yl)-2-(1-benzyl-1H-imidazol-4...)
Affinity DataIC50:  21nMAssay Description:In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248094(CHEMBL460922 | N-((1-methyl-1'-(propylsulfonyl)-2,...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human glycine transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Merck And

Curated by ChEMBL
LigandPNGBDBM50195178(2-chloro-6-fluoro-N-((4-(morpholine-4-carbonyl)-1-...)
Affinity DataIC50:  22nMAssay Description:Inhibition of rat GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248063(2,4-dichloro-N-((4-(2-methoxyethyl)-1-(propylsulfo...)
Affinity DataIC50:  27nMAssay Description:Inhibition of Glyt1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Mus musculus)
Merck And

Curated by ChEMBL
LigandPNGBDBM50195173(2-chloro-4-fluoro-N-((4-(morpholine-4-carbonyl)-1-...)
Affinity DataIC50:  29nMAssay Description:Inhibition of mouse GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248099(2,4-dichloro-N-((4-(cyclopropylmethyl)-1-(propylsu...)
Affinity DataIC50:  30nMAssay Description:Inhibition of Glyt1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248664(CHEMBL465426 | N-((1-(propylsulfonyl)-4-(pyridin-2...)
Affinity DataIC50:  31nMAssay Description:Inhibition of human glycine transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135940(3-(6-Amino-pyridin-3-yl)-2-(1-ethyl-1H-imidazol-4-...)
Affinity DataIC50:  36nMAssay Description:In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248666(2-chloro-N-((4-(4-methylpyridin-2-yl)-1-(propylsul...)
Affinity DataIC50:  38nMAssay Description:Inhibition of human glycine transporter 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50248098(CHEMBL462148 | N-((4-(azetidin-1-yl)-1-(propylsulf...)
Affinity DataIC50:  38nMAssay Description:Inhibition of Glyt1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Mus musculus)
Merck And

Curated by ChEMBL
LigandPNGBDBM50195166(3-chloro-2,6-difluoro-N-((4-(morpholine-4-carbonyl...)
Affinity DataIC50:  43nMAssay Description:Inhibition of mouse GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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