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Found 2841 with Last Name = 'tong' and Initial = 'y'
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50365698(CHEMBL1958411)
Affinity DataKi:  0.0900nMAssay Description:Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50365703(CHEMBL1958417)
Affinity DataKi:  0.110nMAssay Description:Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50365699(CHEMBL1958412)
Affinity DataKi:  0.120nMAssay Description:Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50365702(CHEMBL1958416)
Affinity DataKi:  0.140nMAssay Description:Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50365700(CHEMBL1958414)
Affinity DataKi:  0.180nMAssay Description:Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50365701(CHEMBL1958415)
Affinity DataKi:  0.180nMAssay Description:Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50365706(CHEMBL1958420)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50365705(CHEMBL1958419)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50365704(CHEMBL1958418)
Affinity DataKi:  0.25nMAssay Description:Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50365695(CHEMBL1958408)
Affinity DataKi:  0.280nMAssay Description:Inhibition of human Cdc7 using biotin-C6linker-TPSDSLIYDDGLS as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50365693(CHEMBL1958406)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50365695(CHEMBL1958408)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50365692(CHEMBL1958404)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300018(2-(4-(Oxazol-5-yl)phenyl)-1H-benzo[d]imidazole-4-c...)
Affinity DataKi:  0.760nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50426461(CHEMBL2322677)
Affinity DataKi:  0.900nMAssay Description:Inhibition of human Cdc7 using biotin-C6linker-TPSDSLIYDDGLS as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300015(2-(4-(Pyridin-3-yl)phenyl)-1H-benzo[d]imidazole-4-...)
Affinity DataKi:  0.950nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM333146(Compound I | US10196404, Example 1 | US10196404, E...)
Affinity DataKi: <1nMAssay Description:Inhibition of FITC-labeled Bak BH3 peptide binding to GST-tagged MCL1 (171 to 327 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)...More data for this Ligand-Target Pair
TargetWee1-like protein kinase(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50043654(CHEMBL3355539)
Affinity DataKi: <1nMAssay Description:Inhibition of GST-tagged human Wee1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300008(2-(4-(1,3,4-Oxadiazol-2-yl)phenyl)-1H-benzo[d]imid...)
Affinity DataKi:  1nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50043648(CHEMBL3355533)
Affinity DataKi: <1nMAssay Description:Inhibition of GST-tagged human Wee1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50043649(CHEMBL3355534)
Affinity DataKi: <1nMAssay Description:Inhibition of GST-tagged human Wee1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50043651(CHEMBL3355536)
Affinity DataKi: <1nMAssay Description:Inhibition of GST-tagged human Wee1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50043652(CHEMBL3355537)
Affinity DataKi: <1nMAssay Description:Inhibition of GST-tagged human Wee1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50043653(CHEMBL3355538)
Affinity DataKi: <1nMAssay Description:Inhibition of GST-tagged human Wee1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50365696(CHEMBL1958409)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50519614(CHEMBL4439276)
Affinity DataKi: <1.20nMAssay Description:Binding affinity to C-terminal MBP-fused human MCL1 (173 to 321 residues) expressed in Escherichia coli BL21(DE3)pLysS incubated for 2 hrs by fluores...More data for this Ligand-Target Pair
TargetWee1-like protein kinase(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50043646(CHEMBL3355531)
Affinity DataKi:  1.20nMAssay Description:Inhibition of GST-tagged human Wee1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300019(2-(4-(1H-Imidazol-5-yl)phenyl)-1H-benzo[d]imidazol...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50426464(CHEMBL2322674)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human Cdc7 using biotin-C6linker-TPSDSLIYDDGLS as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50365694(CHEMBL1958407)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50043643(CHEMBL3355528)
Affinity DataKi:  1.60nMAssay Description:Inhibition of GST-tagged human Wee1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300009(2-(4-(5-Oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)pheny...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300021(2-(4-(Thiazol-4-yl)phenyl)-1H-benzo[d]imidazole-4-...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50426467(CHEMBL2322683)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human Cdc7 using biotin-C6linker-TPSDSLIYDDGLS as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300016(2-(4-(Pyridin-2-yl)phenyl)-1H-benzo[d]imidazole-4-...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50365689(CHEMBL1958401)
Affinity DataKi:  2nMAssay Description:Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300017(2-(biphenyl-4-yl)-1H-benzo[d]imidazole-4-carboxami...)
Affinity DataKi:  2nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50043650(CHEMBL3355535)
Affinity DataKi:  2nMAssay Description:Inhibition of GST-tagged human Wee1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300023(2-(4-(2-Aminothiazol-4-yl)phenyl)-1H-benzo[d]imida...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300020(2-(4-(1H-Imidazol-2-yl)phenyl)-1H-benzo[d]imidazol...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50043633(CHEMBL3355518)
Affinity DataKi:  2.30nMAssay Description:Inhibition of GST-tagged human Wee1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300022(2-(4-(2-Methyloxazol-4-yl)phenyl)-1H-benzo[d]imida...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM26707(7-chloro-9-ethyl-6-hydroxy-1H,3H,4H,9H-quinolino[2...)
Affinity DataKi:  2.5nM ΔG°:  -48.6kJ/molepH: 7.5 T: 2°CAssay Description:Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300005(2-(4-(Imidazo[1,2-a]pyridin-2-yl)phenyl)-1H-benzo[...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300014(2-(4-(Pyridin-4-yl)phenyl)-1H-benzimidazole-4-carb...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50426468(CHEMBL2322682)
Affinity DataKi:  3.20nMAssay Description:Inhibition of human Cdc7 using biotin-C6linker-TPSDSLIYDDGLS as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50426466(CHEMBL2322684)
Affinity DataKi:  3.40nMAssay Description:Inhibition of human Cdc7 using biotin-C6linker-TPSDSLIYDDGLS as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300011(2-(4-(5-Thioxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)ph...)
Affinity DataKi:  3.80nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300007(2-(4-(3-Methyl-1,2,4-oxadiazol-5-yl)phenyl)-1H-ben...)
Affinity DataKi:  4nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50300013(2-(4-(1-Methyl-1H-pyrazol-3-yl)phenyl)-1H-benzo[d]...)
Affinity DataKi:  4.5nMAssay Description:Inhibition of PARP1 by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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