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Found 130 with Last Name = 'trummlitz' and Initial = 'g'
LigandPNGBDBM50226901(CHEMBL280600)
Affinity DataKi:  6nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor was determined in homogenized rat cortex tissue using [3H]N-methylscopolamine as radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50021847(5-[2-(4-Methyl-piperazin-1-yl)-acetyl]-5,10-dihydr...)
Affinity DataKi:  23nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor was determined in homogenized rat cortex tissue using [3H]N-methylscopolamine as radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50021850(11-(3-Dimethylamino-propionyl)-5,11-dihydro-benzo[...)
Affinity DataKi:  45nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor was determined in homogenized rat cortex tissue using [3H]N-methylscopolamine as radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50226900(CHEMBL29330)
Affinity DataKi:  50nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor was determined in homogenized rat cortex tissue using [3H]N-methylscopolamine as radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM39341(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Affinity DataKi:  60nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor was determined in homogenized rat cortex tissue using [3H]N-methylscopolamine as radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)
Affinity DataKi:  65nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor was determined in homogenized rat cortex tissue using [3H]N-methylscopolamine as radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50226897(CHEMBL29289)
Affinity DataKi:  200nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor was determined in homogenized rat cortex tissue using [3H]N-methylscopolamine as radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50226898(CHEMBL28973)
Affinity DataKi:  200nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor was determined in homogenized rat cortex tissue using [3H]N-methylscopolamine as radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50226899(CHEMBL31780)
Affinity DataKi:  240nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor was determined in homogenized rat cortex tissue using [3H]N-methylscopolamine as radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50057000(6-Chloro-3-hydroxy-2-methyl-1,1-dioxo-1,2-dihydro-...)
Affinity DataIC50:  7nMAssay Description:Concentration of drug that causes a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 2 activity as measured by PGE2 production('+...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50057004(6-Chloro-3-hydroxy-2-methyl-1,1-dioxo-1,2-dihydro-...)
Affinity DataIC50:  8nMAssay Description:Concentration of drug that causes a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 2 activity as measured by PGE2 production('+...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50023655(11-[2-(1-Methyl-piperidin-2-yl)-acetyl]-5,11-dihyd...)
Affinity DataIC50:  8nMAssay Description:Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50056994(6-Chloro-3-hydroxy-2-methyl-1,1-dioxo-1,2-dihydro-...)
Affinity DataIC50:  9nMAssay Description:Concentration of drug that causes a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 2 activity as measured by PGE-2 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50023655(11-[2-(1-Methyl-piperidin-2-yl)-acetyl]-5,11-dihyd...)
Affinity DataIC50:  10nMAssay Description:Binding affinity towards muscarinic receptor of cerebral cortex containing Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50023662(11-[2-(1-Methyl-pyrrolidin-3-yl)-acetyl]-5,11-dihy...)
Affinity DataIC50:  20nMAssay Description:Binding affinity towards muscarinic receptor of cerebral cortex containing Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50021847(5-[2-(4-Methyl-piperazin-1-yl)-acetyl]-5,10-dihydr...)
Affinity DataIC50:  23nMAssay Description:Binding affinity towards Muscarinic acetylcholine receptor M1 of cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50018304(11-(2-{2-[(Cycloheptyl-methyl-amino)-methyl]-piper...)
Affinity DataIC50:  30nMAssay Description:Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50018292(11-[2-(2-Diethylaminomethyl-piperidin-1-yl)-acetyl...)
Affinity DataIC50:  30nMAssay Description:Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50018302(9-Chloro-11-[2-(2-diethylaminomethyl-piperidin-1-y...)
Affinity DataIC50:  40nMAssay Description:Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50057004(6-Chloro-3-hydroxy-2-methyl-1,1-dioxo-1,2-dihydro-...)
Affinity DataIC50:  41nMAssay Description:Concentration of drug that causes a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 1 activity as measured by PGE2 production('+...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50056997(3-Hydroxy-2-methyl-1-oxo-1,2-dihydro-isoquinoline-...)
Affinity DataIC50:  46nMAssay Description:Concentration of drug that causes a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 2 activity as measured by PGE2 production('+...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50057001(CHEMBL361563 | N-[6-(2,3-Difluoro-phenylsulfanyl)-...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human Prostaglandin G/H synthase 2 at 10 ug/mL expressed as the mean percent inhibition of control PGE-2 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50023659(11-(4-Dimethylamino-butyryl)-5,11-dihydro-benzo[e]...)
Affinity DataIC50:  50nMAssay Description:Binding affinity towards muscarinic receptor of cerebral cortex containing Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50023654(4-[2-(4-Methyl-piperazin-1-yl)-acetyl]-4,9-dihydro...)
Affinity DataIC50:  50nMAssay Description:Binding affinity towards Muscarinic acetylcholine receptor M1 of cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50023662(11-[2-(1-Methyl-pyrrolidin-3-yl)-acetyl]-5,11-dihy...)
Affinity DataIC50:  50nMAssay Description:Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50018291(11-{2-[2-(3-Diethylamino-propyl)-piperidin-1-yl]-a...)
Affinity DataIC50:  60nMAssay Description:Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50018314(11-(2-{2-[(Cyclohexyl-methyl-amino)-methyl]-piperi...)
Affinity DataIC50:  60nMAssay Description:Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50023652(6-Oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazep...)
Affinity DataIC50:  60nMAssay Description:Binding affinity towards Muscarinic acetylcholine receptor M1 of cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50056995(6-Chloro-3-hydroxy-2-methyl-1,1-dioxo-1,2-dihydro-...)
Affinity DataIC50:  64nMAssay Description:Concentration of drug that causes a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 2 activity as measured by PGE2 production('+...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50018304(11-(2-{2-[(Cycloheptyl-methyl-amino)-methyl]-piper...)
Affinity DataIC50:  70nMAssay Description:Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50018294(11-[2-(2-Diethylaminomethyl-piperidin-1-yl)-acetyl...)
Affinity DataIC50:  70nMAssay Description:Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50023656(11-[2-(1-Methyl-piperidin-4-yl)-acetyl]-5,11-dihyd...)
Affinity DataIC50:  70nMAssay Description:Binding affinity towards Muscarinic acetylcholine receptor M1 of cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50056994(6-Chloro-3-hydroxy-2-methyl-1,1-dioxo-1,2-dihydro-...)
Affinity DataIC50:  80nMAssay Description:Concentration of drug that causes a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 1 activity as measured by PGE-2 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50029616(5-(4-Fluoro-phenyl)-1-(4-methanesulfonyl-phenyl)-3...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human Prostaglandin G/H synthase 2 at 10 ug/mL expressed as the mean percent inhibition of control PGE-2 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50021847(5-[2-(4-Methyl-piperazin-1-yl)-acetyl]-5,10-dihydr...)
Affinity DataIC50:  100nMAssay Description:Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50023653(11-[2-(1-Methyl-piperidin-3-yl)-acetyl]-5,11-dihyd...)
Affinity DataIC50:  100nMAssay Description:Binding affinity towards muscarinic receptor of cerebral cortex containing Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50023658(11-[2-(1-Methyl-azepan-4-yl)-acetyl]-5,11-dihydro-...)
Affinity DataIC50:  100nMAssay Description:Binding affinity towards muscarinic receptor of cerebral cortex containing Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50018306(8-Chloro-11-[2-(2-diethylaminomethyl-piperidin-1-y...)
Affinity DataIC50:  100nMAssay Description:Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50023659(11-(4-Dimethylamino-butyryl)-5,11-dihydro-benzo[e]...)
Affinity DataIC50:  100nMAssay Description:Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50018298(11-(2-{2-[(Butyl-methyl-amino)-methyl]-piperidin-1...)
Affinity DataIC50:  100nMAssay Description:Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50023650(6-Oxo-5,6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazep...)
Affinity DataIC50:  100nMAssay Description:Binding affinity towards Muscarinic acetylcholine receptor M1 of cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50018293(11-(2-{2-[(Ethyl-methyl-amino)-methyl]-piperidin-1...)
Affinity DataIC50:  120nMAssay Description:Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50056997(3-Hydroxy-2-methyl-1-oxo-1,2-dihydro-isoquinoline-...)
Affinity DataIC50:  120nMAssay Description:Concentration of drug that causes a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 1 activity as measured by PGE2 production('+...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM39341(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Affinity DataIC50:  120nMAssay Description:Binding affinity towards Muscarinic acetylcholine receptor M1 of cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50023653(11-[2-(1-Methyl-piperidin-3-yl)-acetyl]-5,11-dihyd...)
Affinity DataIC50:  120nMAssay Description:Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50057000(6-Chloro-3-hydroxy-2-methyl-1,1-dioxo-1,2-dihydro-...)
Affinity DataIC50:  140nMAssay Description:Concentration of drug that causes a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 1 activity as measured by PGE2 production('+...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50018297(11-[2-(2-Dimethylaminomethyl-piperidin-1-yl)-acety...)
Affinity DataIC50:  140nMAssay Description:Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50018056((AF-DX 116) 11-[2-(2-Diethylaminomethyl-piperidin-...)
Affinity DataIC50:  140nMAssay Description:Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50023657(11-(4-Methyl-piperazine-1-carbonyl)-5,11-dihydro-b...)
Affinity DataIC50:  150nMAssay Description:Binding affinity towards Muscarinic acetylcholine receptor M1 of cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(RAT)
Dr. Karl Thomae

Curated by ChEMBL
LigandPNGBDBM50018314(11-(2-{2-[(Cyclohexyl-methyl-amino)-methyl]-piperi...)
Affinity DataIC50:  150nMAssay Description:Binding affinity for glandular muscarinic acetylcholine receptor M3 in rat assayed using 0.3 nM [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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