Affinity DataKi: 79nM ΔG°: -40.1kJ/mole IC50: 70nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
Affinity DataKi: 4.90E+3nM ΔG°: -30.0kJ/mole IC50: 4.60E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of src kinaseMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 2(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibition of LCK by LANCE FRET assayMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
Affinity DataIC50: 160nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Inhibition of acidic mammalian chitinase after 60 minsMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 211nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 217nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 270nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 312nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
Affinity DataIC50: 470nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Inhibition of acidic mammalian chitinase after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 900nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
Affinity DataIC50: 2.80E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
Affinity DataIC50: 3.90E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of human CYP2C8More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of human recombinant DHOD expressed in Escherichia coliMore data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
Affinity DataIC50: 8.40E+3nMpH: 7.2 T: 2°CAssay Description:All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...More data for this Ligand-Target Pair