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Found 183 with Last Name = 'tsukaguchi' and Initial = 't'
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50344644(8-(2-(diethylamino)ethoxy)-3-ethoxy-6,6-dimethylbe...)
Affinity DataKi:  170nMAssay Description:Competitive inhibition of ALK phosphorylation by Lineweaver-Burk plot analysisChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100335(CHEMBL2371681 | RO-09-3655 derivative)
Affinity DataIC50:  0.200nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100338(CHEMBL267407 | RO-09-3655 derivative)
Affinity DataIC50:  0.25nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100332(CHEMBL415843 | RO-09-3655 derivative)
Affinity DataIC50:  0.280nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100333(CHEMBL2371765 | RO-09-3655 derivative)
Affinity DataIC50:  0.630nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50479835(CHEMBL510873)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human FTaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50479863(CHEMBL521743)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human FTaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100331(CHEMBL2371715 | RO-09-3655 derivative)
Affinity DataIC50:  0.830nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100329(CHEMBL2371727 | RO-09-3655 derivative)
Affinity DataIC50:  0.890nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50479859(CHEMBL508937)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human FTaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100337(CHEMBL2371766 | RO-09-3655 derivative)
Affinity DataIC50:  0.900nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50479847(CHEMBL514300)
Affinity DataIC50:  1nMAssay Description:Inhibition of human FTaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50362779(CHEMBL1940181 | US9126931, 346)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of ALK using Bio-Gastrintide as substrate by TR-FRET assay in presence of 30 uM of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50362778(CHEMBL1940182)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of ALK using Bio-Gastrintide as substrate by TR-FRET assay in presence of 30 uM of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50479856(CHEMBL454405)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human FTaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50479848(CHEMBL489318)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human FTaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50366679(CHEMBL1793852 | MK-991)
Affinity DataIC50:  1.30nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100336(CHEMBL405487 | RO-09-3655 derivative)
Affinity DataIC50:  1.40nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50479849(CHEMBL489121)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human FTaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50344664(6,6-dimethyl-8-(1-(oxetan-3-yl)piperidin-4-yl)-11-...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of ALK activity by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50344664(6,6-dimethyl-8-(1-(oxetan-3-yl)piperidin-4-yl)-11-...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50344662(8-(4-isopropylpiperazin-1-yl)-6,6-dimethyl-11-oxo-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50362781(1256580-46-7 | AF802 | Alecensa | Alectinib | CH54...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of ALK using Bio-Gastrintide as substrate by TR-FRET assay in presence of 30 uM of ATPMore data for this Ligand-Target Pair
LigandPNGBDBM50479853(CHEMBL511113)
Affinity DataIC50:  2nMAssay Description:Inhibition of human FTaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50479850(CHEMBL475149)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human FTaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50362782(CHEMBL1940179)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of ALK using Bio-Gastrintide as substrate by TR-FRET assay in presence of 30 uM of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50479864(CHEMBL510021)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of human FTaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352764(CHEMBL1823220)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of ALK activity by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50479860(CHEMBL473148)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of human FTaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of ALK using Bio-Gastrintide as substrate by TR-FRET assay in presence of 30 uM of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352760(CHEMBL1823221 | US9126931, 350)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of ALK activity by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50479851(CHEMBL462021)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human FTaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50479857(CHEMBL472956)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human FTaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50479858(CHEMBL453395)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human FTaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100334(CHEMBL407924 | RO-09-3655 derivative)
Affinity DataIC50:  3.60nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50344655(8-[2-(1,1-Dioxo-1lambda-6-thiomorpholin-4-yl)-etho...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50479836(CHEMBL511072)
Affinity DataIC50:  4nMAssay Description:Inhibition of human FTaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50362783(CHEMBL1940178)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of ALK using Bio-Gastrintide as substrate by TR-FRET assay in presence of 30 uM of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50479854(CHEMBL453394)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of human FTaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50479837(CHEMBL516034)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of human FTaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50479838(CHEMBL513211)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of human FTaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50479839(CHEMBL517280)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of human FTaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50344654(8-(2-(diethylamino)ethoxy)-6,6-dimethyl-11-oxo-6,1...)
Affinity DataIC50:  8nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100339(CHEMBL438198 | FR-901469 | FR901469 | Lipopeptidol...)
Affinity DataIC50:  8.5nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50479861(CHEMBL473151)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of human FTaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50352765(CHEMBL1823219)
Affinity DataIC50:  11nMAssay Description:Inhibition of ALK activity by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50479840(CHEMBL475148)
Affinity DataIC50:  11nMAssay Description:Inhibition of human FTaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50479852(CHEMBL473149)
Affinity DataIC50:  11nMAssay Description:Inhibition of human FTaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50344660(8-(4-hydroxypiperidin-1-yl)-6,6-dimethyl-11-oxo-6,...)
Affinity DataIC50:  11.4nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50344656(CHEMBL1779194 | N-(2-(3-cyano-6,6-dimethyl-11-oxo-...)
Affinity DataIC50:  11.6nMAssay Description:Inhibition of ALK assessed as biotin-EGPWLEEEEEAYGWMDF peptide phosphorylation by TR-FRET assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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