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Found 172 with Last Name = 'uecker' and Initial = 'a'
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187351(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Affinity DataIC50:  33nMAssay Description:Inhibition of human FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187351(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Affinity DataIC50:  40nMAssay Description:Inhibition of endogenous FLT3 in EOL1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187340((6-Chloro-1H-indol-2-yl)-(5-methoxy-1H-indol-2-yl)...)
Affinity DataIC50:  55nMAssay Description:Inhibition of human PDGFR betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187345((5-Hydroxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)...)
Affinity DataIC50:  60nMAssay Description:Inhibition of endogenous FLT3 in EOL1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187345((5-Hydroxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM6595(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl 2-(dimethy...)
Affinity DataIC50:  100nMT: 2°CAssay Description:The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187351(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Affinity DataIC50:  100nMAssay Description:Antiproliferative activity against mouse 32Dcl3 cell line expressing wildtype FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187351(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Affinity DataIC50:  100nMAssay Description:Antiproliferative activity against mouse 32Dcl3 cell line expressing FLT3-ITDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187369((5-Fluoro-1H-indol-2-yl)-(5-hydroxy-1H-indol-2-yl)...)
Affinity DataIC50:  170nMAssay Description:Inhibition of endogenous FLT3 in EOL1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187351(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Affinity DataIC50:  171nMAssay Description:Inhibition of human PDGFR betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM6581((5-Hydroxy-1H-2-indolyl)(1H-2-indolyl)-methanone |...)
Affinity DataIC50:  200nMpH: 7.4 T: 2°CAssay Description:The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM6581((5-Hydroxy-1H-2-indolyl)(1H-2-indolyl)-methanone |...)
Affinity DataIC50:  200nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Mus musculus (mouse))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50202219(5-hydroxybenzo[b]furan-2-yl-(5-hydroxy-1Hindol-2-y...)
Affinity DataIC50:  200nMAssay Description:Inhibition of endogenous PDGFRbeta autophosphorylation in Swiss 3T3 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187340((6-Chloro-1H-indol-2-yl)-(5-methoxy-1H-indol-2-yl)...)
Affinity DataIC50:  200nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM6609(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl 2-methoxya...)
Affinity DataIC50:  200nMT: 2°CAssay Description:The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187357((4-Methyl-1H-indol-2-yl)-[5-(2-piperidin-1-yl-etho...)
Affinity DataIC50:  220nMAssay Description:Inhibition of human FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50202219(5-hydroxybenzo[b]furan-2-yl-(5-hydroxy-1Hindol-2-y...)
Affinity DataIC50:  270nMAssay Description:Inhibition of endogenous FLT3 autophosphorylation in EOL1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM6574((6-Methoxy-1H-2-indolyl)(1H-2-indolyl)methanone | ...)
Affinity DataIC50:  300nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM6573((5-Methoxy-1H-2-indolyl)(1H-2-indolyl)methanone | ...)
Affinity DataIC50:  300nMpH: 7.4 T: 2°CAssay Description:The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM6574((6-Methoxy-1H-2-indolyl)(1H-2-indolyl)methanone | ...)
Affinity DataIC50:  300nMpH: 7.4 T: 2°CAssay Description:The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM6592(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl acetate | ...)
Affinity DataIC50:  300nMT: 2°CAssay Description:The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187351(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Affinity DataIC50:  300nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM6573((5-Methoxy-1H-2-indolyl)(1H-2-indolyl)methanone | ...)
Affinity DataIC50:  300nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187365((4-Fluoro-1H-indol-2-yl)-(5-hydroxy-1H-indol-2-yl)...)
Affinity DataIC50:  340nMAssay Description:Inhibition of endogenous FLT3 in EOL1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187348((5-Fluoro-1H-indol-2-yl)-(5-methoxy-1H-indol-2-yl)...)
Affinity DataIC50:  400nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50202215((benzo[b]furan-2-yl)-(1H-indol-2-yl)methanone | CH...)
Affinity DataIC50:  400nMAssay Description:Inhibition of endogenous FLT3 autophosphorylation in EOL1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM6610(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl quinoline-...)
Affinity DataIC50:  400nMT: 2°CAssay Description:The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187345((5-Hydroxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)...)
Affinity DataIC50:  458nMAssay Description:Inhibition of human PDGFR betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187351(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Affinity DataIC50:  500nMAssay Description:Inhibition of DNA synthesis in IL3 dependent FDC-P1 cells expressing KIT V558D mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187361((4-Chloro-1H-indol-2-yl)-(5-hydroxy-1H-indol-2-yl)...)
Affinity DataIC50:  500nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187351(Bis-(5-hydroxy-1H-indol-2-yl)-methanone | CHEMBL37...)
Affinity DataIC50:  500nMAssay Description:Inhibition of DNA synthesis in IL3 dependent FDC-P1 cells expressing wildtype KITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187356((5-Fluoro-1H-indol-2-yl)-[5-(2-piperidin-1-yl-etho...)
Affinity DataIC50:  500nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187345((5-Hydroxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)...)
Affinity DataIC50:  500nMAssay Description:Inhibition of DNA synthesis in IL3 dependent FDC-P1 cells expressing KIT V558D mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187345((5-Hydroxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)...)
Affinity DataIC50:  500nMAssay Description:Inhibition of DNA synthesis in IL3 dependent FDC-P1 cells expressing wildtype KITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187366((5-Methoxy-1H-indol-2-yl)-(6-methyl-1H-indol-2-yl)...)
Affinity DataIC50:  510nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187344((5-Hydroxy-1H-indol-2-yl)-(6-methoxy-1H-indol-2-yl...)
Affinity DataIC50:  530nMAssay Description:Inhibition of endogenous FLT3 in EOL1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM6581((5-Hydroxy-1H-2-indolyl)(1H-2-indolyl)-methanone |...)
Affinity DataIC50:  570nMAssay Description:Inhibition of endogenous FLT3 in EOL1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187367((5-Hydroxy-1H-indol-2-yl)-(6-methyl-1H-indol-2-yl)...)
Affinity DataIC50:  580nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187364((6-Fluoro-1H-indol-2-yl)-(5-hydroxy-1H-indol-2-yl)...)
Affinity DataIC50:  590nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Mus musculus (mouse))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50202210(CHEMBL225826 | bis(5-hydroxybenzo[b]furan-2-yl)met...)
Affinity DataIC50:  600nMAssay Description:Inhibition of endogenous PDGFRbeta autophosphorylation in Swiss 3T3 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM6608(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl furan-2-ca...)
Affinity DataIC50:  600nMT: 2°CAssay Description:The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50202220(CHEMBL376787 | bis(5-aminobenzo[b]furan-2-yl)metha...)
Affinity DataIC50:  600nMAssay Description:Inhibition of endogenous FLT3 autophosphorylation in EOL1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187365((4-Fluoro-1H-indol-2-yl)-(5-hydroxy-1H-indol-2-yl)...)
Affinity DataIC50:  620nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187344((5-Hydroxy-1H-indol-2-yl)-(6-methoxy-1H-indol-2-yl...)
Affinity DataIC50:  650nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187373((5-Hydroxy-1H-indol-2-yl)-(4-methoxy-1H-indol-2-yl...)
Affinity DataIC50:  670nMAssay Description:Inhibition of endogenous FLT3 in EOL1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187357((4-Methyl-1H-indol-2-yl)-[5-(2-piperidin-1-yl-etho...)
Affinity DataIC50:  700nMAssay Description:Inhibition of endogenous FLT3 in EOL1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Mus musculus (mouse))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50202216(CHEMBL226182 | bis(5-acetoxybenzo[b]furan-2-yl)met...)
Affinity DataIC50:  700nMAssay Description:Inhibition of endogenous PDGFRbeta autophosphorylation in Swiss 3T3 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187369((5-Fluoro-1H-indol-2-yl)-(5-hydroxy-1H-indol-2-yl)...)
Affinity DataIC50:  730nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187362((5-Hydroxy-1H-indol-2-yl)-(5-methyl-1H-indol-2-yl)...)
Affinity DataIC50:  740nMAssay Description:Inhibition of endogenous FLT3 in EOL1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50187349((5-fluoro-1H-indol-2-yl)-(1H-indol-2-yl)methanone ...)
Affinity DataIC50:  760nMAssay Description:Inhibition of endogenous PDGFR in Swiss3T3 fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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