TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 1.70nMAssay Description:Displacement of [3H]ABP688 from human mGluR5 receptor expressed in L (tk-) cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 1.80nMAssay Description:Displacement of [3H]ABP688 from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid type B receptor subunit 1(Rattus norvegicus (Rat))
Novartis Pharma
Curated by PDSP Ki Database
Novartis Pharma
Curated by PDSP Ki Database
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 3.5nMAssay Description:Displacement of [3H]M-MPEP from human mGluR5 receptor expressed in L (tk-) cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 10nMAssay Description:Displacement of [3H]ABP688 from human mGluR5 receptor expressed in L (tk-) cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 11nMAssay Description:Displacement of [3H]ABP688 from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 19nMAssay Description:Displacement of [3H]ABP688 from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:Displacement of [3H]ABP688 from human mGluR5 receptor expressed in L (tk-) cellsMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid type B receptor subunit 1(Rattus norvegicus (Rat))
Novartis Pharma
Curated by PDSP Ki Database
Novartis Pharma
Curated by PDSP Ki Database
Affinity DataKi: 85nMAssay Description:Antagonistic activity against stimulation of GTP (gamma) 35 S binding by glutamate in membranes from CHO cells expressing human Metabotropic glutamat...More data for this Ligand-Target Pair
Affinity DataKi: 2.70E+3nMAssay Description:Antagonistic activity against stimulation of GTP (gamma) 35 S binding by glutamate in membranes from CHO cells expressing human Metabotropic glutamat...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]ABP688 from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]ABP688 from human mGluR5 receptor expressed in L (tk-) cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 2.30nMAssay Description:Activity at human recombinant mGluR5 expressed in L(tk-) cells assessed as inhibition of glutamate-induced calcium releaseMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Activity at human recombinant mGluR5 expressed in L(tk-) cells assessed as inhibition of quisqualate-induced phosphoinositol accumulationMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Displacement of [3H]M-MPEP from human mGluR5 receptor expressed in L (tk-) cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Compound was evaluated for the inhibition of binding of [3H]glutamate against rat recombinant mGluR3 receptors expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 75nMAssay Description:Compound was evaluated for the inhibition of binding of [3H]glutamate against rat recombinant Metabotropic glutamate receptor 3 expressed in HEK293 c...More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Antagonistic activity against stimulation of GTP (gamma) 35 S binding by glutamate in membranes from CHO cells expressing human mGluR2More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Antagonistic activity against stimulation of GTP (gamma) 35 S binding by glutamate in membranes from CHO cells expressing human Metabotropic glutamat...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Compound was evaluated for the inhibition of binding of [3H]glutamate against rat recombinant Metabotropic glutamate receptor 3 expressed in HEK293 c...More data for this Ligand-Target Pair
Affinity DataIC50: 6.40E+3nMAssay Description:Antagonistic activity against stimulation of GTP (gamma) 35 S binding by glutamate in membranes from CHO cells expressing human Metabotropic glutamat...More data for this Ligand-Target Pair
Affinity DataIC50: 2.80E+4nMAssay Description:Activity at rat NR1/NR2A receptor expressed in Xenopus oocytes assessed as inhibition of glycine-induced electrophysiological responseMore data for this Ligand-Target Pair
Affinity DataIC50: 6.50E+4nMAssay Description:Activity at rat NR1/NR2A receptor expressed in Xenopus oocytes assessed as inhibition of glycine-induced electrophysiological responseMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+5nMAssay Description:Activity at rat NR1/NR2A receptor expressed in Xenopus oocytes assessed as inhibition of glycine-induced electrophysiological responseMore data for this Ligand-Target Pair
Affinity DataKd: 5.00E+4nMAssay Description:Activity at rat NR1/NR2A receptor expressed in Xenopus oocytes assessed as inhibition of glycine-induced electrophysiological responseMore data for this Ligand-Target Pair
Affinity DataEC50: 7.40E+3nMAssay Description:Antagonistic activity against stimulation of GTP (gamma) 35 S binding by glutamate in membranes from CHO cells expressing human mGluR2More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKd: 2.30nMAssay Description:Binding affinity at mGluR5 in rat brain membraneMore data for this Ligand-Target Pair