TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil...More data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 65nMAssay Description:Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil...More data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 95nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil...More data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil...More data for this Ligand-Target Pair
Affinity DataIC50: 240nMAssay Description:Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil...More data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 310nMAssay Description:Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil...More data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 310nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 310nMAssay Description:Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil...More data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 430nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 450nMAssay Description:Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil...More data for this Ligand-Target Pair
Affinity DataIC50: 510nMAssay Description:Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil...More data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 510nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 540nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 590nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 810nMAssay Description:Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil...More data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 840nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 880nMAssay Description:Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 970nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of PDGFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Compound was evaluated for displacement of radiolabelled [I-125]GRP from rat brain receptor; 1.5-3 microMMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Compound was evaluated for displacement of radiolabelled [I-125]GRP from rat brain receptor; 1.5-3 microMMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil...More data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetMembrane-bound transcription factor site-1 protease(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of human S1P expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assayMore data for this Ligand-Target Pair