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Found 82 with Last Name = 'van dun' and Initial = 'j'
TargetSerotonin 2 (5-HT2) receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50025124(3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-...)
Affinity DataKi:  0.170nMAssay Description:Evaluated for binding activity against [3H]ketanserin as radioligand for 5-hydroxytryptamine 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50025124(3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-...)
Affinity DataKi:  1.20nMAssay Description:Compound was evaluated for binding activity against [3H]pyrilamine as radioligand for Histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50025124(3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-...)
Affinity DataKi:  5.5nMAssay Description:Compound was evaluated for binding activity against [3H]-WB- 4101 as radioligand for alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50025124(3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-...)
Affinity DataKi:  164nMAssay Description:Compound was evaluated for binding activity against [3H]-haloperidol as radioligand for Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50025124(3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-...)
Affinity DataKi:  4.42E+3nMAssay Description:Compound was evaluated for binding activity against [3H]haloperidol as radioligand for Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50127246(8-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50127246(8-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of Geranylgeranylprotein transferase-I at 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50025124(3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-...)
Affinity DataIC50:  0.562nMAssay Description:Evaluated for binding activity against [3H]ketanserin as radioligand for 5-hydroxytryptamine 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136383((4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136383((4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of Geranylgeranylprotein transferase-I catalyzed incorporation of [3H]-GGPP into biotinYRASNRSCAIL peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50126335(6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50126335(6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50126335(6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136377(4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-(4-methyl...)
Affinity DataIC50:  1nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50127248(6-(3-Chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(...)
Affinity DataIC50:  1nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136375(6-[Amino-(4-chloro-phenyl)-(4-methyl-4H-[1,2,4]tri...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136385(C-(4-Chloro-phenyl)-C-[5-(3-chloro-phenyl)-1-methy...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50127252(8-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136384((4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136384((4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of Geranylgeranylprotein transferase-I catalyzed incorporation of [3H]-GGPP into biotinYRASNRSCAIL peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136379(4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-hydroxy-(...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50127254(9-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304782(CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human HDAC11More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50025124(3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-...)
Affinity DataIC50:  2.20nMAssay Description:Compound was evaluated for binding activity against [3H]pyrilamine as radioligand for Histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304782(CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136376(4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-(3-methyl...)
Affinity DataIC50:  3nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136389(C-(4-Chloro-phenyl)-C-[5-(3-chloro-phenyl)-[1,2,4]...)
Affinity DataIC50:  3nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136384((4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of Geranylgeranylprotein transferase-I catalyzed incorporation of [3H]-GGPP into biotinYRASNRSCAIL peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50127255(6-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136380(4-(3-Chloro-phenyl)-6-[1-(4-chloro-phenyl)-1-(3-me...)
Affinity DataIC50:  4nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50127247(1-(3-Chloro-phenyl)-9-[(4-chloro-phenyl)-hydroxy-(...)
Affinity DataIC50:  4nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136378(4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-hydroxy-(...)
Affinity DataIC50:  4nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304782(CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of human HDAC10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304782(CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of human HDAC4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136382(4-(3-Chloro-phenyl)-6-[1-(4-chloro-phenyl)-1-(4-me...)
Affinity DataIC50:  5nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136386(C-(4-Chloro-phenyl)-C-[5-(3-chloro-phenyl)-imidazo...)
Affinity DataIC50:  5nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50127249(6-(3-Chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(...)
Affinity DataIC50:  6nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50127257(6-(3-Chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(...)
Affinity DataIC50:  6nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136381(4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-hydroxy-(...)
Affinity DataIC50:  6nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50127250(6-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136387(C-(4-Chloro-phenyl)-C-[5-(3-chloro-phenyl)-imidazo...)
Affinity DataIC50:  7nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304783((+)-2-(4-(4-(4-fluorophenyl)-1-hydroxybut-3-en-2-y...)
Affinity DataIC50:  7.10nMAssay Description:Inhibition of human HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304782(CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...)
Affinity DataIC50:  7.10nMAssay Description:Inhibition of human HDAC5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304782(CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human HDAC3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304782(CHEMBL609583 | N-hydroxy-2-(4-(naphthalen-2-ylsulf...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50025124(3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-...)
Affinity DataIC50:  15nMAssay Description:Compound was evaluated for binding activity against [3H]pyrilamine as radioligand for Histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304783((+)-2-(4-(4-(4-fluorophenyl)-1-hydroxybut-3-en-2-y...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304783((+)-2-(4-(4-(4-fluorophenyl)-1-hydroxybut-3-en-2-y...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human HDAC11More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Ortho-Biotech Oncology Research & Development

Curated by ChEMBL
LigandPNGBDBM50304783((+)-2-(4-(4-(4-fluorophenyl)-1-hydroxybut-3-en-2-y...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human HDAC5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136383((4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a...)
Affinity DataIC50:  22nMAssay Description:Inhibition of Geranylgeranylprotein transferase-I catalyzed incorporation of [3H]-GGPP into biotinYRASNRSCAIL peptide at 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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