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Found 458 with Last Name = 'wallace' and Initial = 'n'
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394718(CHEMBL2165801)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human Adenosine receptor A2a assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154039(2-Amino-1-[3-(5-bromo-4-phenyl-1H-imidazol-2-yl)-3...)
Affinity DataKi:  0.110nMAssay Description:Binding affinity for delta opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50017698(4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N,N...)
Affinity DataKi:  0.160nMAssay Description:Binding affinity for Mu opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154035((S)-2-amino-3-(4-hydroxyphenyl)-1-((S)-3-(5-methyl...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity for delta opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394722(CHEMBL2165807)
Affinity DataKi:  0.300nMAssay Description:Antagonist activity at human Adenosine receptor A2a assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154035((S)-2-amino-3-(4-hydroxyphenyl)-1-((S)-3-(5-methyl...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity for delta opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50214370(CHEMBL227134 | N-(4-{2-[[2-(4-methanesulfonylamino...)
Affinity DataKi:  0.390nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394718(CHEMBL2165801)
Affinity DataKi:  0.5nMAssay Description:Antagonist activity at human Adenosine receptor A1 assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394717(CHEMBL2165802)
Affinity DataKi:  0.5nMAssay Description:Antagonist activity at human Adenosine receptor A2a assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394719(CHEMBL2165800)
Affinity DataKi:  0.700nMAssay Description:Antagonist activity at human Adenosine receptor A2a assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50316892(2-amino-4-phenyl-8-(2-(pyridin-4-yl)ethylamino)-5H...)
Affinity DataKi:  0.900nMAssay Description:Antagonistic activity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154036((S)-2-amino-3-(4-hydroxyphenyl)-1-((S)-3-(4-phenyl...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity for delta opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50316893(2-amino-4-phenyl-8-(2-(pyridin-2-yl)ethylamino)-5H...)
Affinity DataKi:  0.900nMAssay Description:Antagonistic activity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394720(CHEMBL2165799)
Affinity DataKi:  1.30nMAssay Description:Antagonist activity at human Adenosine receptor A2a assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394721(CHEMBL2165808)
Affinity DataKi:  1.40nMAssay Description:Antagonist activity at human Adenosine receptor A2a assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50491094(CHEMBL2377092)
Affinity DataKi:  1.40nMAssay Description:Antagonist activity at human adenosine A2a receptor expressed in CHOK1 cells assessed as inhibition of NECA/forskolin-induced cAMP accumulation incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154041((S)-2-amino-3-(4-hydroxyphenyl)-1-((S)-2-(5-methyl...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity for Mu opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394716(CHEMBL2165803)
Affinity DataKi:  1.60nMAssay Description:Antagonist activity at human Adenosine receptor A2a assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394715(CHEMBL2165804)
Affinity DataKi:  1.80nMAssay Description:Antagonist activity at human Adenosine receptor A2a assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394717(CHEMBL2165802)
Affinity DataKi:  1.80nMAssay Description:Antagonist activity at human Adenosine receptor A1 assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50491101(CHEMBL2377103)
Affinity DataKi:  2.40nMAssay Description:Antagonist activity at human adenosine A2a receptor expressed in CHOK1 cells assessed as inhibition of NECA/forskolin-induced cAMP accumulation incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394722(CHEMBL2165807)
Affinity DataKi:  2.40nMAssay Description:Antagonist activity at human Adenosine receptor A1 assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394719(CHEMBL2165800)
Affinity DataKi:  2.5nMAssay Description:Antagonist activity at human Adenosine receptor A1 assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50316899(2-amino-8-(4-methylpiperazin-1-yl)-4-phenyl-5H-ind...)
Affinity DataKi:  2.70nMAssay Description:Antagonistic activity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM24226(1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxypheny...)
Affinity DataKi:  2.90nMAssay Description:Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50316898(2-amino-8-morpholino-4-phenyl-5H-indeno[1,2-d]pyri...)
Affinity DataKi:  2.90nMAssay Description:Antagonistic activity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50491105(CHEMBL2377110)
Affinity DataKi:  2.90nMAssay Description:Antagonist activity at human adenosine A2a receptor expressed in CHOK1 cells assessed as inhibition of NECA/forskolin-induced cAMP accumulation incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394723(CHEMBL2165806)
Affinity DataKi:  3.10nMAssay Description:Antagonist activity at human Adenosine receptor A2a assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50316895(2-Amino-8-[2-(1,1-dioxo-1lambda*6*-thiomorpholin-4...)
Affinity DataKi:  3.10nMAssay Description:Antagonistic activity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50214364(11-ethyl-1-(3-{[2-(4-methanesulfonylamino-phenoxy)...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50491075(CHEMBL2377111)
Affinity DataKi:  3.70nMAssay Description:Antagonist activity at human adenosine A2a receptor expressed in CHOK1 cells assessed as inhibition of NECA/forskolin-induced cAMP accumulation incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50330987(2-amino-4-phenyl-8-(pyrrolidin-1-ylmethyl)-5H-inde...)
Affinity DataKi:  4.10nMAssay Description:Antagonist activity at human Adenosine receptor A2a assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50316894(2-amino-8-(2-morpholinoethylamino)-4-phenyl-5H-ind...)
Affinity DataKi:  4.40nMAssay Description:Antagonistic activity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50491100(CHEMBL2377228)
Affinity DataKi:  4.70nMAssay Description:Antagonist activity at human adenosine A2a receptor expressed in CHOK1 cells assessed as inhibition of NECA/forskolin-induced cAMP accumulation incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50316891(2-amino-8-((2-(dimethylamino)ethyl)(methyl)amino)-...)
Affinity DataKi:  4.70nMAssay Description:Antagonistic activity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50316897(2-amino-8-((1-ethylpiperidin-4-yl)(methyl)amino)-4...)
Affinity DataKi:  4.90nMAssay Description:Antagonistic activity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154042(2-[2-Amino-3-(4-hydroxy-phenyl)-propionyl]-1,2,3,4...)
Affinity DataKi:  5.20nMAssay Description:Binding affinity for delta opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394721(CHEMBL2165808)
Affinity DataKi:  5.20nMAssay Description:Antagonist activity at human Adenosine receptor A1 assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50394720(CHEMBL2165799)
Affinity DataKi:  6nMAssay Description:Antagonist activity at human Adenosine receptor A1 assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50491113(CHEMBL2377091)
Affinity DataKi:  6.20nMAssay Description:Antagonist activity at human adenosine A2a receptor expressed in CHOK1 cells assessed as inhibition of NECA/forskolin-induced cAMP accumulation incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50031720((Dofetilide) N-[4-(2-{[2-(4-Methanesulfonylamino-p...)
Affinity DataKi:  6.40nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50316887(2-amino-8-(2-morpholinoethoxy)-4-phenyl-5H-indeno[...)
Affinity DataKi:  6.5nMAssay Description:Antagonist activity at human Adenosine receptor A2a assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50316887(2-amino-8-(2-morpholinoethoxy)-4-phenyl-5H-indeno[...)
Affinity DataKi:  6.5nMAssay Description:Antagonistic activity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50491099(CHEMBL2377232)
Affinity DataKi:  6.90nMAssay Description:Antagonist activity at human adenosine A2a receptor expressed in CHOK1 cells assessed as inhibition of NECA/forskolin-induced cAMP accumulation incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50214372(24-{[(6-{[2-(4-methanesulfonamidophenoxy)ethyl][2-...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50491098(CHEMBL2377093)
Affinity DataKi:  7.30nMAssay Description:Antagonist activity at human adenosine A2a receptor expressed in CHOK1 cells assessed as inhibition of NECA/forskolin-induced cAMP accumulation incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50031720((Dofetilide) N-[4-(2-{[2-(4-Methanesulfonylamino-p...)
Affinity DataKi:  7.70nMAssay Description:Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50316870(2-amino-N-(2-(diethylamino)ethyl)-N-methyl-5-oxo-4...)
Affinity DataKi:  7.80nMAssay Description:Antagonistic activity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50316883(2-amino-8-(2-(diethylamino)ethoxy)-4-phenyl-5H-ind...)
Affinity DataKi:  7.90nMAssay Description:Antagonistic activity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50316876(2-amino-8-(4-methylpiperazine-1-carbonyl)-4-phenyl...)
Affinity DataKi:  8.20nMAssay Description:Antagonistic activity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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