Found 396 with Last Name = 'wang' and Initial = 'hy' TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Displacement of [3H]-pentazocin from the Sigma1 receptorMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Displacement of [3H]-pentazocin from the Sigma1 receptorMore data for this Ligand-Target Pair
3D Structure (crystal)TargetSigma intracellular receptor 2(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 2.5nMAssay Description:Displacement of [3H]-DTG from the Sigma2 receptorMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 10nMAssay Description:Displacement of [3H]-pentazocin from the Sigma1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Inhibition of human recombinant nNOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production measured for ...More data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Inhibition of human neuronal NOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production by measuring oxid...More data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Inhibition of rat neuronal NOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production by measuring oxidat...More data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Inhibition of rat recombinant nNOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production measured for 6 ...More data for this Ligand-Target Pair
Affinity DataKi: 16.4nM ΔG°: -46.2kJ/molepH: 7.4 T: 2°CAssay Description:The assay was performed at 37 °C in HEPES buffer (100 mM, with 10% glycerol, pH 7.4) in the presence of 10 uM L-arginine. Also included were 100 ...More data for this Ligand-Target Pair
Affinity DataKi: 17nM ΔG°: -46.1kJ/molepH: 7.4 T: 2°CAssay Description:The assay was performed at 37 °C in HEPES buffer (100 mM, with 10% glycerol, pH 7.4) in the presence of 10 uM L-arginine. Also included were 100 ...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:Activity of compound against Muscarinic acetylcholine receptor M1 (CHRM1) by displacement of 3H-QNBMore data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Inhibition of rat recombinant nNOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production measured for 6 ...More data for this Ligand-Target Pair
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 25nMAssay Description:Displacement of [3H]-DTG from the Sigma2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 25.2nM ΔG°: -45.1kJ/molepH: 7.4 T: 2°CAssay Description:The assay was performed at 37 °C in HEPES buffer (100 mM, with 10% glycerol, pH 7.4) in the presence of 10 uM L-arginine. Also included were 100 ...More data for this Ligand-Target Pair
Affinity DataKi: 26nMAssay Description:Inhibition of rat neuronal NOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production by measuring oxidat...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 28nMAssay Description:Activity of compound against Muscarinic acetylcholine receptor M5 (CHRM5) by displacement of 3H-QNBMore data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Inhibition of human neuronal NOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production by measuring oxid...More data for this Ligand-Target Pair
Affinity DataKi: 37nMAssay Description:Inhibition of human recombinant nNOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production measured for ...More data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of rat neuronal NOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production by measuring oxidat...More data for this Ligand-Target Pair
Affinity DataKi: 42.6nM ΔG°: -43.8kJ/molepH: 7.4 T: 2°CAssay Description:The assay was performed at 37 °C in HEPES buffer (100 mM, with 10% glycerol, pH 7.4) in the presence of 10 uM L-arginine. Also included were 100 ...More data for this Ligand-Target Pair
Affinity DataKi: 43nMAssay Description:Inhibition of human neuronal NOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production by measuring oxid...More data for this Ligand-Target Pair
Affinity DataKi: 43nMAssay Description:Inhibition of rat recombinant nNOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production measured for 6 ...More data for this Ligand-Target Pair
Affinity DataKi: 44nMAssay Description:Inhibition of rat neuronal NOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production by measuring oxidat...More data for this Ligand-Target Pair
Affinity DataKi: 46.7nM ΔG°: -43.5kJ/molepH: 7.4 T: 2°CAssay Description:The assay was performed at 37 °C in HEPES buffer (100 mM, with 10% glycerol, pH 7.4) in the presence of 10 uM L-arginine. Also included were 100 ...More data for this Ligand-Target Pair
Affinity DataKi: 47nMAssay Description:Inhibition of rat neuronal NOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production by measuring oxidat...More data for this Ligand-Target Pair
Affinity DataKi: 48nMAssay Description:Inhibition of rat neuronal NOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production by measuring oxidat...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 54nMAssay Description:Activity of compound against Muscarinic acetylcholine receptor M4 (CHRM4) by displacement of 3H-QNBMore data for this Ligand-Target Pair
Affinity DataKi: 55nMAssay Description:Inhibition of human neuronal NOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production by measuring oxid...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 56nMAssay Description:Activity of compound against Muscarinic acetylcholine receptor M3 (CHRM3) by displacement of 3H-QNBMore data for this Ligand-Target Pair
Affinity DataKi: 57nMAssay Description:Inhibition of rat neuronal NOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production by measuring oxidat...More data for this Ligand-Target Pair
Affinity DataKi: 60nMAssay Description:Inhibition of rat neuronal NOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production by measuring oxidat...More data for this Ligand-Target Pair
Affinity DataKi: 65nMAssay Description:Inhibition of human neuronal NOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production by measuring oxid...More data for this Ligand-Target Pair
TargetIsoform PNNOS of Nitric oxide synthase, brain (PNNOS) -973,I269V,M336V,D597N](Rattus norvegicus (rats))
University of California Irvine
University of California Irvine
Affinity DataKi: 65.3nM ΔG°: -42.7kJ/molepH: 7.4 T: 2°CAssay Description:The assay was performed at 37 °C in HEPES buffer (100 mM, with 10% glycerol, pH 7.4) in the presence of 10 uM L-arginine. Also included were 100 ...More data for this Ligand-Target Pair
Affinity DataKi: 72nMAssay Description:Inhibition of rat recombinant nNOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production measured for 6 ...More data for this Ligand-Target Pair
Affinity DataKi: 72.3nM ΔG°: -42.4kJ/molepH: 7.4 T: 2°CAssay Description:The assay was performed at 37 °C in HEPES buffer (100 mM, with 10% glycerol, pH 7.4) in the presence of 10 uM L-arginine. Also included were 100 ...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 79nMAssay Description:Displacement of [3H]-pentazocin from the Sigma1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 82nMAssay Description:Inhibition of human neuronal NOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production by measuring oxid...More data for this Ligand-Target Pair
Affinity DataKi: 83nMAssay Description:Inhibition of human neuronal NOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production by measuring oxid...More data for this Ligand-Target Pair
Affinity DataKi: 84nMAssay Description:Inhibition of human recombinant nNOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production measured for ...More data for this Ligand-Target Pair
Affinity DataKi: 87nMAssay Description:Displacement of 1,8-ANS from FABP4 (unknown origin) after 3 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 89nMAssay Description:Inhibition of human recombinant nNOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production measured for ...More data for this Ligand-Target Pair
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 95nMAssay Description:Displacement of [3H]-DTG from the Sigma2 receptorMore data for this Ligand-Target Pair
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 95nMAssay Description:Displacement of [3H]-DTG from the Sigma2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 97.5nM ΔG°: -41.6kJ/molepH: 7.4 T: 2°CAssay Description:The assay was performed at 37 °C in HEPES buffer (100 mM, with 10% glycerol, pH 7.4) in the presence of 10 uM L-arginine. Also included were 100 ...More data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Inhibition of human neuronal NOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production by measuring oxid...More data for this Ligand-Target Pair
TargetIsoform PNNOS of Nitric oxide synthase, brain (PNNOS) -973,I269V,M336V,D597N](Rattus norvegicus (rats))
University of California Irvine
University of California Irvine
Affinity DataKi: 108nM ΔG°: -41.4kJ/molepH: 7.4 T: 2°CAssay Description:The assay was performed at 37 °C in HEPES buffer (100 mM, with 10% glycerol, pH 7.4) in the presence of 10 uM L-arginine. Also included were 100 ...More data for this Ligand-Target Pair
TargetIsoform PNNOS of Nitric oxide synthase, brain (PNNOS) -973,I269V,M336V,D597N](Rattus norvegicus (rats))
University of California Irvine
University of California Irvine
Affinity DataKi: 117nM ΔG°: -41.2kJ/molepH: 7.4 T: 2°CAssay Description:The assay was performed at 37 °C in HEPES buffer (100 mM, with 10% glycerol, pH 7.4) in the presence of 10 uM L-arginine. Also included were 100 ...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 117nMAssay Description:Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 126nMAssay Description:Displacement of [3H]-pentazocin from the Sigma1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 139nMAssay Description:Inhibition of rat recombinant nNOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production measured for 6 ...More data for this Ligand-Target Pair
