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Found 2552 with Last Name = 'wang' and Initial = 'tc'
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM19023(1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-y...)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM12676(1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-N-[...)
Affinity DataKi:  0.190nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218305(3-chloro-N-((1S,2R)-2-(4-(2-oxopyridin-1(2H)-yl)be...)
Affinity DataKi:  0.210nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218298(5-chloro-N-((1S,2R)-1-(4-(2-oxopyridin-1(2H)-yl)be...)
Affinity DataKi:  0.270nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18161((1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,15-dimethy...)
Affinity DataKi:  0.300nM ΔG°:  -53.8kJ/mole EC50:  2.80nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218280(5-chloro-N-((3R,4S)-1-(2-methoxyacetyl)-4-(4-(2-ox...)
Affinity DataKi:  0.360nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218315((3R,4S)-methyl 3-(2-chlorothiophene-5-carboxamido)...)
Affinity DataKi:  0.390nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50216554(5-CHLORO-N-((1R,2S)-2-(4-(2-OXOPYRIDIN-1(2H)-YL)BE...)
Affinity DataKi:  0.430nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50216554(5-CHLORO-N-((1R,2S)-2-(4-(2-OXOPYRIDIN-1(2H)-YL)BE...)
Affinity DataKi:  0.430nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218308(5-chloro-N-((3R,4S)-1-(methylsulfonyl)-4-(4-(2-oxo...)
Affinity DataKi:  0.440nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50216584(3-chloro-N-((1R,2S)-2-(4-(1-(pyrrolidin-1-ylmethyl...)
Affinity DataKi:  0.440nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218282((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50216572(5-chloro-N-((1R,2S)-2-(4-(1-(pyrrolidin-1-ylmethyl...)
Affinity DataKi:  0.510nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218312((1S,3R,4S)-methyl 3-(2-chlorothiophene-5-carboxami...)
Affinity DataKi:  0.530nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218290(5-chloro-N-((1R,2S,4S)-4-(hydroxymethyl)-2-(4-(2-o...)
Affinity DataKi:  0.560nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218300((3R,4S)-3-(2-chlorothiophene-5-carboxamido)-N,N-di...)
Affinity DataKi:  0.560nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218291(CHEMBL394129 | N-((3R,4S)-1-acetyl-4-(4-(2-oxopyri...)
Affinity DataKi:  0.580nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218283(5-chloro-N-((3R,4S)-1-(ethylsulfonyl)-4-(4-(2-oxop...)
Affinity DataKi:  0.640nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50216556(3-CHLORO-N-((1R,2S) -2-(4-(2-OXOPYRIDIN-1(2H)-YL)B...)
Affinity DataKi:  0.670nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50216604(3-chloro-N-((1R,2S)-2-(4-(2-oxopyridin-1(2H)-yl)be...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50216579(CHEMBL401024 | cis-3-chloro-N-(2-(2-fluoro-4-(2-ox...)
Affinity DataKi:  0.710nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218282((3R,4S)-ethyl 3-(2-chlorothiophene-5-carboxamido)-...)
Affinity DataKi:  0.730nMAssay Description:Inhibition of human factor 10a in presence of tripeptide substrate at 25 degCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218306((3R,4S)-methyl 3-(2-chlorothiophene-5-carboxamido)...)
Affinity DataKi:  0.740nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218319(3-chloro-N-((1R,2S)-2-(4-(2-oxopyridin-1(2H)-yl)be...)
Affinity DataKi:  0.840nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218294((3R,4S)-2-methoxyethyl 3-(2-chlorothiophene-5-carb...)
Affinity DataKi:  0.930nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50216583(3-chloro-N-((1R,2S)-2-(4-(2-oxopyrazin-1(2H)-yl)be...)
Affinity DataKi:  0.940nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50216620(5-chloro-N-((1R,2S)-2-(4-(1-(pyrrolidin-1-ylmethyl...)
Affinity DataKi:  0.950nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50216598(3-chloro-N-((1S,2R)-2-(4-(2-oxopyridin-1(2H)-yl)be...)
Affinity DataKi:  1nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50216598(3-chloro-N-((1S,2R)-2-(4-(2-oxopyridin-1(2H)-yl)be...)
Affinity DataKi:  1nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218301(3-chloro-N-((1S,2R)-1-(4-(2-oxopyridin-1(2H)-yl)be...)
Affinity DataKi:  1nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50216604(3-chloro-N-((1R,2S)-2-(4-(2-oxopyridin-1(2H)-yl)be...)
Affinity DataKi:  1nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18162((1R,6R,7S)-4-(4-nitronaphthalen-1-yl)-2,4-diazatri...)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/mole EC50:  385nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218286((3R,4S)-3-(2-chlorothiophene-5-carboxamido)-N-meth...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50216566(5-chloro-N-((1R,2S)-2-(4-(2-oxopyrazin-1(2H)-yl)be...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM245383(US9428504, 133)
Affinity DataKi:  1.20nM ΔG°:  -50.9kJ/molepH: 7.4 T: 2°CAssay Description:A SPA membrane binding assay was used to identify inhibitors of [33P] 2MeS-ADP binding to cloned human P2Y1 receptors (The P2Y1 receptor membranes we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50216606(3-chloro-N-(2-methyl-1-(4-(2-oxopyridin-1(2H)-yl)b...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218295(5-chloro-N-((3R,4S)-1-isobutyryl-4-(4-(2-oxopyridi...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50216576(CHEMBL231940 | cis-N-(2-(4-(2-oxopyridin-1(2H)-yl)...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18169((7S,7aR)-7-hydroxy-2-(4-nitronaphthalen-1-yl)-hexa...)
Affinity DataKi:  1.5nM ΔG°:  -49.9kJ/mole EC50:  281nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18165((6R)-6-hydroxy-2-(4-nitronaphthalen-1-yl)-hexahydr...)
Affinity DataKi:  1.5nM ΔG°:  -49.9kJ/mole EC50:  320nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50216562(5-CHLORO-N-(2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO)...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50216557(5-chloro-N-((1R,2S)-2-(4-(2-oxopiperidin-1-yl)benz...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218284(5-chloro-N-((1R,2S,4S)-4-(cyclopropylcarbamoyl)-2-...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218314(5-chloro-N-((1R,2S,4S)-4-(morpholine-4-carbonyl)-2...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218304(5-chloro-N-((3R,4S)-1-(isopropylsulfonyl)-4-(4-(2-...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218281(5-chloro-N-((3R,4S)-4-(4-(2-oxopyridin-1(2H)-yl)be...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18164(2-(4-nitronaphthalen-1-yl)-hexahydro-1H-pyrrolo[1,...)
Affinity DataKi:  1.70nM ΔG°:  -49.6kJ/mole EC50:  270nMpH: 7.4 T: 2°CAssay Description:Receptor Binding Assay (Ki)-Binding determined through direct displacement of ligand with [3H]-DHT in the MDA-453 cell line. Transactivation Assay (E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50218296(5-chloro-N-((3R,4S)-4-(4-(2-oxopyridin-1(2H)-yl)be...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50216594(5-chloro-N-(1-(4-(2-oxopyridin-1(2H)-yl)benzamido)...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50216578(5-chloro-N-((1R,2S)-2-(4-(2-oxopyridin-1(2H)-yl)be...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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