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Found 557 with Last Name = 'weatherhead' and Initial = 'jg'
TargetIntegrase(Human immunodeficiency virus 1)
Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50484379(CHEMBL1917873)
Affinity DataIC50:  1nMAssay Description:Inhibition of HIV1 integrase strand transfer by biochemical assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [1148-1435](Human immunodeficiency virus type 1)
Gsk

LigandPNGBDBM28239(2-(7-{5-[(4-fluorophenyl)methyl]-1,3,4-oxadiazol-2...)
Affinity DataIC50:  2nMpH: 7.2 T: 2°CAssay Description:Purified recombinant integrase was first combined in a complex with biotinylated donor DNA- streptavidin-coated SPA beads. The complex was preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [1148-1435](Human immunodeficiency virus type 1)
Gsk

LigandPNGBDBM28269(1,3,4-oxadiazole substituted naphthyridine, 37 | 3...)
Affinity DataIC50:  2nMAssay Description:Purified recombinant integrase was first combined in a complex with biotinylated donor DNA- streptavidin-coated SPA beads. The complex was preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [1148-1435](Human immunodeficiency virus type 1)
Gsk

LigandPNGBDBM28274(1,3,4-oxadiazole substituted naphthyridine, 42 | 4...)
Affinity DataIC50:  2nMAssay Description:Purified recombinant integrase was first combined in a complex with biotinylated donor DNA- streptavidin-coated SPA beads. The complex was preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [1148-1435](Human immunodeficiency virus type 1)
Gsk

LigandPNGBDBM28239(2-(7-{5-[(4-fluorophenyl)methyl]-1,3,4-oxadiazol-2...)
Affinity DataIC50:  2nMAssay Description:Purified recombinant integrase was first combined in a complex with biotinylated donor DNA- streptavidin-coated SPA beads. The complex was preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294622((S)-2-(tert-butoxy)-2-((R)-2-(3,3-difluoropiperidi...)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294623(US10112899, Example 103)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294624((S)-2-(tert-butoxy)-2-((M)-2-(3,3-dimethylbutanoyl...)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294657((S)-2-(tert-butoxy)-2-((R)-2-(5-fluoro-2-methylben...)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294658(US10112899, Example 137)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294659(US10112899, Example 138)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294661(US10112899, Example 140)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294666(US10112899, Example 145)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294670(US10112899, Example 149)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294673(US10112899, Example 152)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294679(US10112899, Example 158)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294680(US10112899, Example 159)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294683(US10112899, Example 162)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294691(US10112899, Example 169)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294692(US10112899, Example 170)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294693(US10112899, Example 171)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294657((S)-2-(tert-butoxy)-2-((R)-2-(5-fluoro-2-methylben...)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294700(US10112899, Example 178)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294706(US10112899, Example 184)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294708(US10112899, Example 186)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294714(US10112899, Example 191)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294719(US10112899, Example 196)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294738((S)-2-(tert-butoxy)-2-((M)-6-(8-fluoro-5-methylchr...)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294814(US10112899, Example 285)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294834(US10112899, Example 305)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294851(US10112899, Example 321)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50489299(CHEMBL2316125)
Affinity DataIC50:  2nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50062551(CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity using [3H]-DNA as substrate preincubated for 60 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [1148-1435](Human immunodeficiency virus type 1)
Gsk

LigandPNGBDBM28285(1,3,4-oxadiazole substituted naphthyridine, 53 | N...)
Affinity DataIC50:  3nMAssay Description:Purified recombinant integrase was first combined in a complex with biotinylated donor DNA- streptavidin-coated SPA beads. The complex was preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50045083(CHEMBL3310085)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant HIV-1 integrase by strand-transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294621((2S)-2-(tert-butoxy)-2-(6-(M)-(8-fluoro-5-methylch...)
Affinity DataIC50:  3nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294640(US10112899, Example 119)
Affinity DataIC50:  3nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294641(US10112899, Example 120)
Affinity DataIC50:  3nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294643(US10112899, Example 122)
Affinity DataIC50:  3nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294667(US10112899, Example 146)
Affinity DataIC50:  3nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294677(US10112899, Example 156)
Affinity DataIC50:  3nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294678(US10112899, Example 157)
Affinity DataIC50:  3nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294682(US10112899, Example 161)
Affinity DataIC50:  3nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294695(US10112899, Example 173)
Affinity DataIC50:  3nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294709(US10112899, Example 187)
Affinity DataIC50:  3nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294718(US10112899, Example 195)
Affinity DataIC50:  3nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294739((S)-2-(tert-butoxy)-2-((M)-2-(4,4-difluoropiperidi...)
Affinity DataIC50:  3nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294740((S)-2-(tert-butoxy)-2-((M)-2-(3,3-dimethylpyrrolid...)
Affinity DataIC50:  3nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294779(US10112899, Example 251)
Affinity DataIC50:  3nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Viiv Healthcare

US Patent
LigandPNGBDBM294847(US10112899, Example 317)
Affinity DataIC50:  3nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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