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Found 870 with Last Name = 'welch' and Initial = 'pk'
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193774((+)1-(3-((2S,4R)-4-(4-fluorobenzyl)piperidin-2-yl)...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064345((3S,5R,14S)-3-(2-Biphenyl-4-yl-ethyl)-14-methylcar...)
Affinity DataKi:  9nMAssay Description:Inhibition of Matrix metalloproteinase-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064346((8R,10S,13S)-13-Methylcarbamoyl-5,11,16-trioxo-10-...)
Affinity DataKi:  10nMAssay Description:Inhibition of Matrix metalloproteinase-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50104969((R)-N*4*-Hydroxy-2-isobutyl-N*1*-[(S)-2-(4-methoxy...)
Affinity DataKi: <10nMAssay Description:Inhibition of Matrix metalloproteinase-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50104969((R)-N*4*-Hydroxy-2-isobutyl-N*1*-[(S)-2-(4-methoxy...)
Affinity DataKi: <10nMAssay Description:Inhibition of Matrix metalloproteinase-1 (MMP-1)More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50104969((R)-N*4*-Hydroxy-2-isobutyl-N*1*-[(S)-2-(4-methoxy...)
Affinity DataKi: <10nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50104969((R)-N*4*-Hydroxy-2-isobutyl-N*1*-[(S)-2-(4-methoxy...)
Affinity DataKi: <10nMAssay Description:Inhibition of Matrix metalloproteinase-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193770(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(2-oxopropyl)pi...)
Affinity DataKi:  11nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064344((3S,5R,14S)-14-(methylcarbamoyl)-2,8-dioxo-3-phene...)
Affinity DataKi:  17nMAssay Description:Inhibition of Matrix metalloproteinase-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193763((+)1-(3-((2S,4R)-4-(4-fluorobenzyl)piperidin-2-yl)...)
Affinity DataKi:  18nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193764((2S,4R)-2-{3-[3-(3,5-diacetyl-phenyl)-ureido]-prop...)
Affinity DataKi:  19nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193764((2S,4R)-2-{3-[3-(3,5-diacetyl-phenyl)-ureido]-prop...)
Affinity DataKi:  31nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193768((+/-)1-(3-acetylphenyl)-3-(3-((2S,4R)-4-benzylpipe...)
Affinity DataKi:  32nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193762((+)1-(3-((2S,4R)-4-benzylpiperidin-2-yl)propyl)-3-...)
Affinity DataKi:  34nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193762((+)1-(3-((2S,4R)-4-benzylpiperidin-2-yl)propyl)-3-...)
Affinity DataKi:  34nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193762((+)1-(3-((2S,4R)-4-benzylpiperidin-2-yl)propyl)-3-...)
Affinity DataKi:  35nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193762((+)1-(3-((2S,4R)-4-benzylpiperidin-2-yl)propyl)-3-...)
Affinity DataKi:  35nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193762((+)1-(3-((2S,4R)-4-benzylpiperidin-2-yl)propyl)-3-...)
Affinity DataKi:  37nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193762((+)1-(3-((2S,4R)-4-benzylpiperidin-2-yl)propyl)-3-...)
Affinity DataKi:  37nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193768((+/-)1-(3-acetylphenyl)-3-(3-((2S,4R)-4-benzylpipe...)
Affinity DataKi:  39nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193760(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(2-hydroxyethyl...)
Affinity DataKi:  40nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193768((+/-)1-(3-acetylphenyl)-3-(3-((2S,4R)-4-benzylpipe...)
Affinity DataKi:  42nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193769(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(2-fluoroethyl)...)
Affinity DataKi:  49nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193781(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(2-hydroxyethyl...)
Affinity DataKi:  50nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193759(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-allylpiperidin-...)
Affinity DataKi:  69nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193774((+)1-(3-((2S,4R)-4-(4-fluorobenzyl)piperidin-2-yl)...)
Affinity DataKi:  95nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193779(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-methylpiperidin...)
Affinity DataKi:  96nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193777(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(cyclopropylmet...)
Affinity DataKi:  117nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193774((+)1-(3-((2S,4R)-4-(4-fluorobenzyl)piperidin-2-yl)...)
Affinity DataKi:  119nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193765(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-propylpiperidin...)
Affinity DataKi:  157nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193765(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-propylpiperidin...)
Affinity DataKi:  166nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290164((R)-3-[(S)-2-(4-Methoxy-phenyl)-1-methylcarbamoyl-...)
Affinity DataKi:  184nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails Article
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290160(3-[(S)-2-(4-Methoxy-phenyl)-1-methylcarbamoyl-ethy...)
Affinity DataKi:  210nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193775(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(3-hydroxypropy...)
Affinity DataKi:  212nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193771(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-allylpiperidin-...)
Affinity DataKi:  217nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193763((+)1-(3-((2S,4R)-4-(4-fluorobenzyl)piperidin-2-yl)...)
Affinity DataKi:  219nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193776(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-propionylpiperi...)
Affinity DataKi:  224nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193763((+)1-(3-((2S,4R)-4-(4-fluorobenzyl)piperidin-2-yl)...)
Affinity DataKi:  233nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50064346((8R,10S,13S)-13-Methylcarbamoyl-5,11,16-trioxo-10-...)
Affinity DataKi:  238nMAssay Description:Inhibition of Matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50064345((3S,5R,14S)-3-(2-Biphenyl-4-yl-ethyl)-14-methylcar...)
Affinity DataKi:  249nMAssay Description:Inhibition of Matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193777(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(cyclopropylmet...)
Affinity DataKi:  251nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193779(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-methylpiperidin...)
Affinity DataKi:  257nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50064345((3S,5R,14S)-3-(2-Biphenyl-4-yl-ethyl)-14-methylcar...)
Affinity DataKi:  288nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290163(3-[(S)-2-(4-Methoxy-phenyl)-1-methylcarbamoyl-ethy...)
Affinity DataKi:  290nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064342((R)-2-[(S)-1-((S)-5-Acetylamino-1-methylcarbamoyl-...)
Affinity DataKi:  293nMAssay Description:Inhibition of Matrix metalloproteinase-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193767(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-propylpiperidin...)
Affinity DataKi:  296nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193759(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-allylpiperidin-...)
Affinity DataKi:  297nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193758(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(prop-2-ynyl)pi...)
Affinity DataKi:  305nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193769(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(2-fluoroethyl)...)
Affinity DataKi:  317nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193773(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(2,2-difluoroet...)
Affinity DataKi:  328nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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